The Effect of Anemia and Blood Transfusions on Mortality in Closed Head Injury Patients

Duane, Therèse M.; Mayglothling, Julie; Grandhi, Ramesh; Warrier, Nisha; Aboutanos, Michel B.; Wolfe, Luke; Malhotra, Ajai K.; Ivatury, Rao R.

doi:10.1016/j.jss.2008.02.044

Cited by 48 publications

(32 citation statements)

References 17 publications

(10 reference statements)

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“…Three were conducted in Canada; 2, in Taiwan; and others, in China, Columbia, Germany, Switzerland, Tunisia, or United Kingdom. Two studies [35,37] were completed before 1999, year of the publication of the TRICC trial [12]; 19 were conducted after its publication [7,17,[26][27][28][29][30][31]33,34,36,38,39,41,42,45,[47][48][49]; and 2 started before and ended after its publication [32,44]. One study did not report a specific timeframe [43].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…One study did not report a specific timeframe [43]. Seventeen studies [7,17,26,27,29,30,[32][33][34][37][38][39][43][44][45]47,48] had RBC transfusion as an exposure or outcome of interest. Other studies reported data on RBC transfusion for descriptive purposes or as a covariate.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Other studies reported data on RBC transfusion for descriptive purposes or as a covariate. Five studies [29,32,44,47,48] excluded patients with multiple trauma. All studies were published in English, except 1 in Chinese [48].…”

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Red Blood Cell Transfusion in Patients With Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Boutin

Chassé

Shemilt

et al. 2016

Transfusion Medicine Reviews

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Red Blood Cell Transfusion in Patients With Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Boutin

Chassé

Shemilt

et al. 2016

Transfusion Medicine Reviews

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“…Blood transfusion has undesirable effects such as aggravation of acute inflammatory response, which contributes to the increased incidence of multiple organ failure 21,22,23 . Duane et al 24 , showed that, although most patients victims of TBI alone do not require blood transfusion, those who need it have higher mortality rates, and these patients are more likely to undergo some surgical intervention. In addition, the most seriously injured patients require more frequently blood transfusion, which leads to maintenance of systemic inflammatory response 25 .…”

Section: Discussionmentioning

confidence: 99%

Hemotransfusion and mechanical ventilation time are associated with intra-hospital mortality in patients with traumatic brain injury admitted to intensive care unit

Almeida¹,

Rodrigues

Lemos

et al. 2016

Arq. Neuro-Psiquiatr.

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Objective To identify the factors associated with the intra-hospital mortality in patients with traumatic brain injury (TBI) admitted to intensive care unit (ICU). Methods The sample included patients with TBI admitted to the ICU consecutively in a period of one year. It was defined as variables the epidemiological characteristics, factors associated with trauma and variables arising from clinical management in the ICU. Results The sample included 87 TBI patients with a mean age of 28.93 ± 12.72 years, predominantly male (88.5%). The intra-hospital mortality rate was of 33.33%. The initial univariate analysis showed a significant correlation of intra-hospital death and the following variables: the reported use of alcohol (p = 0.016), hemotransfusion during hospitalization (p = 0.036), and mechanical ventilation time (p = 0.002). Conclusion After multivariate analysis, the factors associated with intra-hospital mortality in TBI patients admitted to the intensive care unit were the administration of hemocomponents and mechanical ventilation time.

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“…Trauma patients who receive blood transfusions have a twofold to sixfold increase in systemic inflammatory response syndrome and a more than fourfold increase in ICU admissions [38]. However, some studies of general trauma patients have failed to demonstrate a relationship between RBCT and adverse outcome [105]. In a substudy of the TRICC trial, 203 trauma patients, 25% of whom were identified as having brain injury, were randomized to a liberal versus restrictive strategy transfusion [106].…”

Section: Traumatic Brain Injurymentioning

confidence: 99%

Red Blood Cell Transfusion in the Neurological ICU

Kumar

2012

Neurotherapeutics

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Red blood cell transfusion (RBCT) is a common therapy used in the intensive care unit to treat anemia. However, due to deleterious side effects and questionable efficacy, the clinical benefit of RBCT in patients who are not actively bleeding is unclear. The results of randomized controlled trials suggest there is no benefit to a liberal transfusion practice in general critical care populations. Whether the results of these trials are applicable to brain injured patients is unknown, as patients with primary neurological injury were excluded. This article reviews the efficacy and complications of RBCT, as well as the relationship between RBCT and its outcome in both the general intensive care unit and neurologically critically ill populations.

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The Effect of Anemia and Blood Transfusions on Mortality in Closed Head Injury Patients

Cited by 48 publications

References 17 publications

Red Blood Cell Transfusion in Patients With Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Red Blood Cell Transfusion in Patients With Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Hemotransfusion and mechanical ventilation time are associated with intra-hospital mortality in patients with traumatic brain injury admitted to intensive care unit

Red Blood Cell Transfusion in the Neurological ICU

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