The effect of an acidified, ionized copper sulphate solution on digital dermatitis in dairy cows

Holzhauer, M.; Bartels, C.J.M.; Bergsten, C. Fred; Riet, M.M.J. van; Frankena, K.; Lam, TH

doi:10.1016/j.tvjl.2012.06.049

Cited by 35 publications

(21 citation statements)

References 24 publications

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“…This study has been one of few footbath protocol evaluations conducted on multiple farms. Most research on footbath protocols has been conducted on single farms (Holzhauer et al, 2008b;Speijers et al, 2010Speijers et al, , 2012Teixeira et al, 2010;Holzhauer et al, 2012), with sample sizes <400 cows (Silva et al, 2005;Thomsen et al, 2008;Smith et al, 2014) and follow-up periods usually span 4-wk to 4-mo intervals. Research with multiple farms and longer follow-up periods (Relun et al, 2012) has demonstrated that including multiple farms with varying characteristics can improve outcome precision.…”

Section: Itemmentioning

confidence: 99%

Comparison of the efficacy of a commercial footbath product with copper sulfate for the control of digital dermatitis

Jacobs

Orsel

Mason

et al. 2017

Journal of Dairy Science

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Digital dermatitis (DD) is the most prevalent foot lesion affecting dairy herds worldwide. Its implications include production losses and decreased animal welfare. Footbathing is the most common herd-level prevention strategy for DD. Because many common footbath products have negative environmental and health consequences, replacement products expected to have improved safety but equal efficacy are being developed. Therefore, the aim of this study was to evaluate the efficacy of a new quaternary ammonium-based commercial footbath product (QAC) for reducing the prevalence of active DD lesions compared with an industry standard (copper sulfate; CuSO) and typical on-farm footbath practices. A controlled intervention trial was conducted on 19 Alberta dairy farms over 12 wk, with 9 farms allocated to the QAC group (1% QAC daily, 5 d/wk), 5 to the CuSO group (5% CuSO daily, 5 d/wk), and 5 to a noninterference group (maintained typical footbath practices). A total of 22,285 observations on 3,465 lactating cows were assessed for DD lesions and leg cleanliness in the milking parlor. Five farms discontinued use of the QAC product for various reasons. Noninferiority analysis was used to assess QAC ability to decrease the proportion of cows with 1 or more active DD lesions compared with CuSO after 6 wk. Multilevel logistic regression models for repeated measures were used to evaluate efficacy of QAC compared with CuSO and noninterference farms in reducing the prevalence of active DD lesions at the foot level over 12 wk. The noninferiority analysis determined that the proportion of cows with 1 or more active DD lesion decreased 2.19 (95% CI: 1.39-3.46) times less after 6 wk of study on the QAC farms compared with CuSO farms, making QAC inferior to CuSO. The multilevel logistic regression models determined that the proportion of active DD lesions increased in the QAC herds, whereas this proportion decreased in the CuSO and noninterference herds over 12 wk. Additionally, cows in mid- and late-lactation had a higher odds of having active DD compared with fresh cows. Older cows (parity 3 and ≥4) had a decreased odds of active DD compared with first-parity cows. At the farm level, a higher baseline active DD prevalence resulted in increased odds of active DD; however, this did not modify the effect of treatment or week of study. We concluded that QAC was inferior to CuSO and typical on-farm footbath practices, and further development of novel footbath products is required to develop an ideal alternative.

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Section: Itemmentioning

confidence: 99%

Comparison of the efficacy of a commercial footbath product with copper sulfate for the control of digital dermatitis

Jacobs

Orsel

Mason

et al. 2017

Journal of Dairy Science

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“…Paper 2: The effect of an acidified, ionized copper sulfate solution on digital dermatitis in dairy cows4…”

Section: Summary Of Evidencementioning

confidence: 99%

“…The study by Holzhauer and colleagues4 used an acidified, ionised copper sulfate solution, but it is unknown whether the copper sulfate solution used in Laven and Hunt’s study3 was acidified and/or ionised. This makes direct comparison between the two studies difficult.…”

Section: Commentsmentioning

confidence: 99%

Are copper sulfate footbaths as effective as formalin footbaths in reducing clinical signs of digital dermatitis in dairy cattle?

Stavisky

2020

Veterinary Record

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“…There is substantial literature on the use of foot baths for control of PDD, which is not addressed here. [9][10][11][12][13][14][15][16][17] Randomized, Masked, Prospective Trials with Negative Controls for Topical Therapy for Papillomatous Digital Dermatitis…”

Section: Papillomatous Digital Dermatitis (Hairy Heel Wart Strawberrmentioning

confidence: 99%

Clinical Evidence for Individual Animal Therapy for Papillomatous Digital Dermatitis (Hairy Heel Wart) and Infectious Bovine Pododermatitis (Foot Rot)

Apley

2015

Veterinary Clinics of North America: Food Animal Practice

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The effect of an acidified, ionized copper sulphate solution on digital dermatitis in dairy cows

Cited by 35 publications

References 24 publications

Comparison of the efficacy of a commercial footbath product with copper sulfate for the control of digital dermatitis

Comparison of the efficacy of a commercial footbath product with copper sulfate for the control of digital dermatitis

Are copper sulfate footbaths as effective as formalin footbaths in reducing clinical signs of digital dermatitis in dairy cattle?

Clinical Evidence for Individual Animal Therapy for Papillomatous Digital Dermatitis (Hairy Heel Wart) and Infectious Bovine Pododermatitis (Foot Rot)

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