The effect of amlodipine on blood glucose level and its interaction with oral hypoglycemic drugs in albino rabbits

Abstract

Background: Amlodipine used as many cardiac conditions esp in hypertension. Diabetes affects cardiovascular system adversely. So this study was done to see effect of amlodipine on blood glucose level and its interaction with commonly used oral hypoglycemic agents in diabetic & non diabetic albino rabbits. Methods: Rabbits were divided into nine groups of 6 rabbits in each group. I and II group were non-diabetic given normal saline and amlodipine respectively. Group III to IX were made diabetic by using alloxan monohydrate (150mg/kg i.p.) & given normal saline, glimepiride, metformin, pioglitazone, amlodipine + glimepiride, amlodipine + metformin and amlodipine + pioglitazone respectively. All drugs were given orally once daily for 7 day except group VII, VIII and IX in which glimepiride, metformin and pioglitazone were added on 7 th day. After GTT blood glucose level were measured at 0, 1, 2 and 6 hours on 7 th day in all groups by using spectrophotometer. Results: After 7 days of treatment the amlodipine produced significant hyperglycemia in normal rabbits. Amlodipine on combination, causes significant decreased in hypoglycemic effect of glimepiride, significant increased the hypoglycemic effect of metformin, while no significant changes in hypoglycemic effects of pioglitazone in diabetic rabbits. Conclusion:The present study shows that amlodipine causes hyperglycemia in normal rabbits. Amlodipine significantly altered hypoglycemic effect of glimepiride and metformin as compared to control group. If these finding are true to human beings then amlodipine should be use cautiously in diabetic patient on oral hypoglycemic drugs.

The Evaluation of Fasting Plasma Glucose (FPG) Levels in Hypertensive Patients Using Calcium Channel Blocker (CCB) Drugs Class in Undata Regional Hospital

“…These results are in line with the research conducted by Sandozi (2010), in which the results proved to significantly increase fasting plasma glucose levels of 20 patients was using the CCB antihypertensive group namely amlodipine in the doses of 2.5-10 mg once taken daily for 2-4 weeks. This is also in line with a study carried out by Prajapat, Jain, Singh, Singh, & Agarwal (2013), which stated that amlodipine can significantly increase fasting plasma glucose levels in non-diabetic albino rabbits for 1, 2, and 6 hours after administration of 0.35 mg per kg per day. A study conducted by Sushma et al (2012) gained results of research conducted on albino rabbits which did not suffer from diabetes and the data obtained indicated significantly higher values of the test group were rabbits that had been given amlodipine orally compared to the controlled group which was only given distilled water during the 3 days of treatment, where the results obtained indicated that the mean value of the tested group was significantly higher than the controlled group (p less than 0.001).…”

“…Calcium channel blockers cause hyperglycemia by directly inhibiting insulin secretion. Thus, it is possible that amlodipine, a calcium channel blocker, can affect insulin release, and hence, the occurrence of glucose tolerance may happen to normal and diabetic individuals (Prajapat et al, 2013). According to Medscape (2019), the mechanism of insulin secretion is induced by an increase in plasma glucose levels.…”

Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study

“…Therefore, it should be used cautiously in diabetic patients. 18 Similarly, another common interaction (>10%) seen in our study was between metformin and thyroxine. Metformin enhances the effect of thyroxine which is to increases blood glucose.…”