The fabrication and characterization of fully visible-transparent and flexible ultraviolet (UV) detectors, on polyethylene 2,6-naphthalate (PEN) with active channels of zinc oxide nanowires and ohmic indium tin oxide contacts, are reported and discussed. The fabricated detector has an average transmittance of 80% in the visible spectral range and is most responsive at or below 370 nm, the onset of UV light, with a UV/vis rejection ratio of 1.42 × 103. A five orders of magnitude difference in the photocurrent, between UV illumination and dark conditions, are also observed. The single-sided UV response further shows that the PEN substrate performs well as a UV reflector. The noise analysis on the nanowire UV detector indicates a noise equivalent power and detectivity (D*) of 5.88 × 10−13 WHz−0.5 and 2.13 × 109 cm Hz0.5 W−1, respectively.