The effect of air bubble position after blastocyst transfer on pregnancy rates in IVF cycles

Friedman, Bruce J.; Lathi, Ruth B.; Henne, Melinda; Fisher, Sophie; Milki, Amin A.

doi:10.1016/j.fertnstert.2008.07.1605

Cited by 10 publications

(20 citation statements)

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“…In our center, distance of air bubble to fundus was controlled in 15-20 millimetres range, and the data suggested no signi cant difference between HP and IUP (17.55 ± 1.80 mm vs. 17.32 ± 1.75 mm, p = 0.55). The result was consistent with study by Friedman et al which reported that air bubble position too close to the fundus (10 mm) probably ended in a tubal pregnancy while a distance of 15-20 millimetres would achieved a higher rate of embryo implantation [12]. That is a possible explanation for the comparable data on distance of air bubble to fundus between the two groups in our center.…”

Section: Discussionsupporting

confidence: 93%

Risk factors and pregnancy outcomes of heterotopic pregnancy secondary to in vitro fertilization-embryo transfer: A case series study

Zhu

Zhang

Song

2020

Preprint

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Background: The early diagnosis and treatment of heterotopic pregnancy (HP) remain one of the biggest challenges in the field of gynecology. A coexisting intrauterine gestation makes the ectopic pregnancy in HP more difficult to diagnose. This case series analysis is designed to explore factors affecting the incidence of HP secondary to in vitro fertilization-embryo transfer (IVF-ET) and that affecting pregnancy outcomes after surgical treatment of HP.Methods: From the IVF registry system, the clinical data of 29 patients with HP and 92 with an intrauterine-only pregnancy (IUP) following embryo transfer from January 2009 to December 2017 were retrospectively analyzed.Results HP had a higher proportion of previous ectopic pregnancies, multiple abortion history ( ≧ 2 times) and tubal indication for IVF than IUP. In patients with HP, 31.03% had spontaneous abortion, 25.00% had preterm delivery and 58.62% resulted in a live birth. According to the results from logistic regression, history of multiple abortions (odds ratio (OR) 3.031, 95% confidence intervals (CI) 1.087-8.453; P=0.034), tubal infertility (OR 3.844, 95% CI 1.268-11.656; P=0.017), previous ectopic pregnancies (OR 2.303, 95% CI 0.625-8.490; P=0.021) and multiple embryo transfer ( OR 0.300, 95% CI 0.092-0.983; P=0.037) resulted in an elevated proportion of HP in IVF cycles. Incidence of HP was comparable between patients transferred with blastocyst and cleavage embryos. Shorter operative duration, smaller size of the ectopic mass and location in the ampulla of the fallopian tube were associated with higher chance of survival in the coexistent intrauterine pregnancy after surgical treatment with HP.Conclusions:The early diagnosis of HP remains a challenge. Previous history of ectopic pregnancy, multiple abortions, tubal infertility and multiple embryo transfer may be considered as meaningful risk factors of subsequent HP following IVF-ET. In patients with HP treated by surgery, shorter operative duration, smaller size of the ectopic mass and location in the ampulla of the fallopian tube means better reproductive prognosis.

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Section: Discussionsupporting

confidence: 93%

Risk factors and pregnancy outcomes of heterotopic pregnancy secondary to in vitro fertilization-embryo transfer: A case series study

Zhu

Zhang

Song

2020

Preprint

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“…These results are consistent with Friedman et al [5] who found that the pregnancy rates were significantly higher in the group in which the air bubble was <10 mm from the fundus (62.5%) than 10-20 mm group (42.0%) and > 20 mm group (38.3%) after controlling for age, parity, FSH and frozen transfers, and accounting for repeated cycles per patient.…”

Section: Discussionsupporting

confidence: 91%

“…Studies of implantation sites in spontaneous and IVF pregnancies have revealed that gestational sacs most often implant near the uterine fundus compared with middle and lower uterine segment implantation. Significantly higher endometrial tissue blood flow in the fundus can enhance the ability of blastocysts to implant in this location [5] . In contrast, Kovacs et al [1] evaluated transfer depth assessed by air bubble location after ET in relation to pregnancy outcome and reported that air bubble location didn't affect implantation and pregnancy rates when it was in the middle or upper third of the uterus.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Relationship between Air Bubbles Depth and Pregnancy Rate in ICSI Cycles

ElBishrey

Makled

Gomaa

et al. 2017

EJHM

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Objective: to determine the relationship between embryo transfer outcome and the distance between fundal endometrial surface and air bubbles assessed by trans-abdominal ultrasound Design: Prospective (cohort) study Setting: This study was conducted in assisted reproductive technology (ART) unit of Ain Shams University Hospital from April 2015 to October 2016. Patient(s): Eighty two women undergoing ICSI were enrolled in and a written informed consent was obtained from each participant. Intervention(s): no patient received any additional procedure or intervention. Outcome measuers: The primary outcome was biochemical pregnancy rate based on serum beta-hCG level at 14 days after ET. Secondary outcome was clinical pregnancy rate using trans-vaginal US examination at 6-8 weeks of amenorrhea to detect the presence of fetal sac & pulsation. Results: Implantation, biochemical and clinical pregnancy rates were significantly higher in distance < 10 mm group than ≥ 10 mm group. Conclusion: air bubble used as an identifier of the position of the embryo at ET can be determinative for pregnancy rates. Clinical PRs were higher in cases with air bubbles < 10 mm from fundal endometrial surface.

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“…Several recent studies have focused on the potential impact of embryo replacement depth on ET outcomes. [60][61][62] Although there is no consensus regarding optimal ET location within the uterine cavity, it seems most likely that fundal transfer is associated with the highest PRs. [60][61][62] The air bubbles can be regarded as an identifier of the position of the embryos in regard to the fundal end of the endometrial cavity.…”

Section: Embryo Expulsionmentioning

confidence: 99%

Practice of Embryo Transfer: Recommendations During and After

Tıraş

Cenksoy

2014

Semin Reprod Med

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Many patient and embryo factors influence the outcome of assisted reproductive technology (ART) treatment. The predictors for a successful ART cycle include female age, ovarian reserve, embryo quality, endometrial receptivity, and embryo transfer (ET) technique. ET, the final step of ART, has recently been noted as a crucial step affecting ART success. Variables affecting pregnancy rates following ET include ultrasound guidance, ease of ET transfer, catheter type, transfer and catheter-loading technique, blood or mucus effects, retained embryos, trial transfer, the physician's experience, and catheter tip placement. Despite the lack of consensus regarding the optimal ET technique, it is generally recommended that during ET, the disruption of the endometrium and the induction of uterine contractions should be avoided. The exposure of embryos to the ambient conditions should be minimized, and the embryo(s) should be placed at an optimal position within the fundal region of the uterine cavity.

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The effect of air bubble position after blastocyst transfer on pregnancy rates in IVF cycles

Cited by 10 publications

References 0 publications

Risk factors and pregnancy outcomes of heterotopic pregnancy secondary to in vitro fertilization-embryo transfer: A case series study

Risk factors and pregnancy outcomes of heterotopic pregnancy secondary to in vitro fertilization-embryo transfer: A case series study

Evaluation of the Relationship between Air Bubbles Depth and Pregnancy Rate in ICSI Cycles

Practice of Embryo Transfer: Recommendations During and After

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