The effect of aging on intestinal absorption and status of calcium, magnesium, zinc, and copper in rats: A stable isotope study

Coudray, Charles; Feillet‐Coudray, Christine; Rambeau, Mathieu; Tressol, J.C.; Gueux, Elyett; Mazur, Andrzej; Rayssiguier, Yves

doi:10.1016/j.jtemb.2005.10.007

Cited by 54 publications

(33 citation statements)

References 41 publications

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“…A study showed that with increasing age, metal uptake decreases in the intestine. Eventual changes in the expression of transporter proteins gene and the increase in cholesterol level were mentioned as the reasons for a decrease in metal absorption [27]. The statistical results presented in Table 1 demonstrated no significant relationship between nickel concentration of breast milk and mothers' job.…”

Section: Discussionmentioning

confidence: 96%

The Nickel Concentration in Breast Milk during the First Month of Lactation in Yazd, Center of Iran

Salmani

Mozaffari‐Khosravi

Rezaei

2016

Biol Trace Elem Res

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Breastfeeding plays an important role in the growth and development of breastfed infants, especially in the first 6 months of their lives. The present study was conducted to determine the nickel concentrations in breast milk of lactating women in Yazd, Iran. One hundred fifty volunteers were selected among nursing mothers referring to health centers in Yazd. In the first month of lactation, milk samples were collected three times, on days 3 to 5 (first), 16 (Second), and 30 (third) after delivery. Nickel concentration of the samples was measured by atomic absorption spectrophotometer. Demographic variables were collected through a questionnaire which was completed by mothers. The mean age of the study group was 27.40 ± 4.66 years. The mean nickel concentrations in breast milk at the first, second, and third samples were 47.3 ± 7.40, 49.9 ± 8.05, and 54.8 ± 7.38 μg/l, respectively. The concentration of nickel in the breast milk of more than 86 % of mothers was higher than the permissible range for it. There was no significant relationship between the mean value of nickel in breast milk and education, age, and job of mothers. High level of nickel in breast milk may be attributed to consumed food and drinking water containing nickel. Monitoring the nickel level in breast milk regularly is recommended.

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Section: Discussionmentioning

confidence: 96%

The Nickel Concentration in Breast Milk during the First Month of Lactation in Yazd, Center of Iran

Salmani

Mozaffari‐Khosravi

Rezaei

2016

Biol Trace Elem Res

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“…Renal responses to sodium restriction are impaired in the elderly [17] ; however in a recent study, mineralocorticoid-sensitive electrogenic sodium absorption was not lower in biopsies from the colon of human volunteers over the age of seventy [18] . The absorption of metal ions as a function of age has not received much attention; however, a recent report of careful studies in the rat suggests that zinc absorption may be considerably decreased, magnesium absorption decreased only moderately, and copper absorption is unaffected [19] . To the author's knowledge, detailed examination of small intestinal metal transporters as a function of age in humans or rodents has not been performed.…”

Section: Intestinal Micronutrient Absorptionmentioning

confidence: 99%

Intestinal Malabsorption in the Elderly

Holt¹

2007

Dig Dis

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Background: Intestinal malabsorption in the elderly is infrequent, and clinical features are muted so that the diagnosis is often missed. Physiologic changes with aging are restricted to altered absorption of calcium and perhaps zinc and magnesium; however, achlorhydria can lead to impaired absorption of vitamin B₁₂, folic acid, and calcium. Methods and Results: Small bowel bacterial overgrowth occurs more commonly in elderly than in younger patients, accompanying gastric hypochlorhydria, altered intestinal motor activity, or diseases such as Parkinson’s disease. Changes in pancreatic anatomy and secretion occur but are insufficient to produce macronutrient malabsorption. In addition to pancreatic cancer and pancreatic stones, older patients may present with severe pancreatic insufficiency of unknown etiology. Celiac disease is recognized as very common at all ages and may not become evident until late in life. Manifestations of celiac disease in the elderly are occult and the diagnosis often is not considered until serologic tests are performed and confirmed by upper small intestinal biopsy. Associated intestinal lymphoma, esophageal carcinoma, intestinal pseudo-obstruction, and splenic atrophy may be more common in the elderly. Treatment of older patients with celiac disease with a gluten-free diet may be difficult, and intensive vitamin and micronutrient replacement is mandatory. A pragmatic approach to the evaluation of malabsorption in elderly patients is discussed.

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“…[7][8][9] Besides an absence of harmful radiation, this approach has the further advantage of enabling multi-element studies, in which different isotopes can be added to the same meal. 10,11 However, it should be noted that spiking with large amounts of enriched-isotopes will result in a change of the dietary net consumption of inorganic nutrients. Moreover,…”

Section: Introductionmentioning

confidence: 99%

Isotopic Analysis of Calcium in Blood Plasma and Bone from Mouse Samples by Multiple Collector-ICP-Mass Spectrometry

et al. 2008

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The biological processing of Ca produces significant stable isotope fractionation. The level of isotopic fractionation can provide key information about the variation in dietary consumption or Ca metabolism. To investigate this, we measured the 43 Ca/ 42 Ca and 44 Ca/ 42 Ca ratios for bone and blood plasma samples collected from mice of various ages using multiple collector-ICP-mass spectrometry (MC-ICP-MS). The 44 Ca/ 42 Ca ratio in bones was significantly (0.44 -0.84‰) lower than the corresponding ratios in the diet, suggesting that Ca was isotopically fractionated during Ca metabolism for bone formation. The resulting 44 Ca/ 42 Ca ratios for blood plasma showed almost identical, or slightly higher, values (0.03 -0.2‰) than found in a corresponding diet. This indicates that a significant amount of Ca in the blood plasma was from dietary sources. Unlike that discovered for Fe, there were no significant differences in the measured 44 Ca/ 42 Ca ratios between female and male specimens (for either bone or blood plasma samples). Similarity, the 44 Ca/ 42 Ca ratios suggests that there were no significant differences in Ca dietary consumption or Ca metabolism between female and male specimens. In contrast, the 44 Ca/ 42Ca ratios of blood plasma from mother mice during the lactation period were significantly higher than those for all other adult specimens. This suggests that Ca supplied to infants through lactation was isotopically lighter, and the preferential supply of isotopically lighter Ca resulted in isotopically heavier Ca in blood plasma of mother mice during the lactation period. The data obtained here clearly demonstrate that the Ca isotopic ratio has a potential to become a new tool for evaluating changes in dietary consumption, or Ca metabolism of animals. both of these two isotope tracer approaches are based on the assumption that the spiked isotope replaces the native element, and behaves in an identical manner. 1This indicates that mimicing of the isotopes to the native nutrients must be considered in order to obtain reliable data for elemental metabolism. Faced with this problem, we have developed a new isotope tracer technique based on changes in the isotopic composition of Ca due to a mass-dependent isotopic effect. Hence, no spiking with additional elements, such as radio isotopes or enriched isotopes, was required, and therefore, no mimicing to the native nutrients is required. Moreover, it should be noted that the present stable isotope approach allows regular monitoring of the nutritional status of Ca of the donor without any spiking or addition of isotopes. The measurement of stable isotopes of nitrogen ( 15 N/ 14 N) and carbon ( 13 C/ 12 C) is a useful tool to trace trophic relationships and food webs. 3,12,13 This method assumes that, during the assimilation process, there is an enrichment in heavy isotopes (i.e., 13 C or 15 N) compared to the dietary intake, which is compensated by the preferential excretion of lighter isotopes. 14,15 The isotopic composition of an animals' tissue reflec...

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The effect of aging on intestinal absorption and status of calcium, magnesium, zinc, and copper in rats: A stable isotope study

Cited by 54 publications

References 41 publications

The Nickel Concentration in Breast Milk during the First Month of Lactation in Yazd, Center of Iran

The Nickel Concentration in Breast Milk during the First Month of Lactation in Yazd, Center of Iran

Intestinal Malabsorption in the Elderly

Isotopic Analysis of Calcium in Blood Plasma and Bone from Mouse Samples by Multiple Collector-ICP-Mass Spectrometry

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