The effect of age on five ions of the kidney in the Fischer 344 rat

Baskin, Steven I.; Kuhar, Kim P.; Uricchio, Francis J.; Harper, Gregory

doi:10.1051/rnd:19810508

Cited by 11 publications

(6 citation statements)

References 7 publications

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“…Maintenance of constant internal ion concentrations (e.g., sodium, potassium, chloride, calcium and magnesium) is essential for active regulation of water influx and ion efflux in aquatic organisms (Mayer et al, 1992). Any imbalance in the levels of these ions in animals will lead to impairment of various physiological activities (Baskin, Kuhar, Uricchio, & Harper, 1981). Freshwater fishes are hyper osmotic to their medium and so they gain water osmotically and level to loose solutes by diffusion.…”

Section: Introductionmentioning

confidence: 99%

Alterations in the Levels of Ions in Blood and Liver of Freshwater Fish, Cyprinus carpio var. communis Exposed to Dimethoate

Logaswamy¹,

Radha²,

Subhashini³

et al. 2006

Environ Monit Assess

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The fingerlings of Cyprinus carpio var. communis were exposed to sublethal concentration of dimethoate for 7, 14 days to evaluate the impact of the pesticide dimethoate on different ions namely sodium, potassium, chloride, calcium, magnesium. The blood potassium, calcium, magnesium and liver chloride and magnesium levels were elevated under sublethal condition. The blood sodium, chloride and liver sodium, potassium, and calcium levels were found to be significantly decreased.

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Section: Introductionmentioning

confidence: 99%

Alterations in the Levels of Ions in Blood and Liver of Freshwater Fish, Cyprinus carpio var. communis Exposed to Dimethoate

Logaswamy¹,

Radha²,

Subhashini³

et al. 2006

Environ Monit Assess

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show abstract

“…They also provide proper ionic balance for normal neuromuscular irritability and tissue functions (Harper ; Adedeji ). Any imbalance in the levels of these ions will lead to impairment of various physiological activities (Baskin, Kuhar, Uricchio & Harper ). In freshwater fish, the physiological regulation of major electrolytes is very sensitive to environment stressors and the measurement of these ions (Na + , K + , Cl − ) have potential as sensitive biomarkers of chemical exposure and effects and provide good indices of pathological changes in ion regulating tissues (Larsson, Haux & Sjobeck ; Suvetha, Ramesh & Saravanan ).…”

Section: Introductionmentioning

confidence: 99%

Effect of ammonia on the electrolyte status of an Indian major carp Catla catla

2012

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Ammonia is present in the aquatic environment due to agricultural runoff, sewage effluents and decomposition of biological waste. High level of ammonium in the aquatic environment or in aquaculture farms is a serious problem for aquatic organisms. In the present investigation, the sublethal effects of total ammonia nitrogen (TAN) at 9.98 mg L À1 on plasma electrolytes (Na + , K + and Cl À ) level of Indian major carp Catla catla fingerlings was studied for a period of 35 days under semistatic conditions. Exposure of fish to sublethal concentration of TAN at 9.98 mg L À1 caused changes in the levels of plasma electrolytes (Na + , K + and Cl À ) compared with control fish. No mortality was observed in any group during the treatment period. The present study reveals that the levels of plasma sodium and potassium (except on 7th day) electrolytes were significantly (P < 0.05) decreased throughout the study period. However, the decrease in plasma chloride level was found to be not significant when compared with control group. The present study concludes that the measurements of plasma electrolytes levels can be used as potential biomarkers for monitoring nitrogenous chemicals in aquatic environment.

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“…The ''free radical theory of aging'' proposes that aging allows for gradual damage to biomolecules via free radical reactions [5]. The molecular mechanism(s) responsible for these changes is still not fully understood, but it has been reported that iron causes oxidative stress in the body, while other studies have demonstrated that aging in animals (rats) and humans is associated with increases in iron accumulation [6][7][8][9].…”

mentioning

confidence: 98%

Deferasirox Decreases Age-Associated Iron Accumulation in the Aging F344XBN Rat Heart and Liver

et al. 2010

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It is thought that aging in rats and humans is associated with increases in iron accumulation and cell apoptosis. Here, we examine the relationship between cardiac iron levels and apoptosis in aged F344XBN rats that had been treated with an oral iron chelator (Deferasirox; 100 mg/kg body weight) on alternate days for 6 months. Compared to adult animals (6 month), cardiac iron (+72%), liver iron (+87%), ferritin light chain (+59%), divalent metal transporter-1 (+56%) and the number of TdT-mediated dUTP nick end labeling (TUNEL) positive cells (4.3 fold increase) were higher in 33-month-old animals (P < 0.05). Deferasirox treatment decreased cardiac iron levels by 37% (P < 0.05), and this was associated with decreases in the number of TUNEL-positive cells. Age-associated increases in cell death were coupled with increases in Bax to Bcl-2 ratio, and the amount of Bad, full-length caspase-3, and cleaved caspase-3. Deferasirox treatment decreased the Bax to Bcl-2 ratio by 17% (P < 0.05) and the amount of Bad, full-length caspase-3, cleaved caspase-3 (19 kDa), and cleaved caspase-3 (17 kDa) by 41, 16, 22, and 37%, respectively (P < 0.05). Taken together, these data suggest that deferasirox may be effective in diminishing age-associated iron accumulation and cardiac apoptosis in the F344XBN rat model.

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The effect of age on five ions of the kidney in the Fischer 344 rat

Abstract: Introduction.

Cited by 11 publications

References 7 publications

Alterations in the Levels of Ions in Blood and Liver of Freshwater Fish, Cyprinus carpio var. communis Exposed to Dimethoate

Alterations in the Levels of Ions in Blood and Liver of Freshwater Fish, Cyprinus carpio var. communis Exposed to Dimethoate

Effect of ammonia on the electrolyte status of an Indian major carp Catla catla

Deferasirox Decreases Age-Associated Iron Accumulation in the Aging F344XBN Rat Heart and Liver

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