The effect of aerobic walking and lower body resistance exercise on serum COMP and hyaluronan, in both males and females

Abstract

The effect of a single bout of lower body exercise on serum COMP and HA is independent of exercise modality in healthy men and women. Furthermore, having thicker femoral cartilage and higher baseline COMP in males does not appear to influence how the cartilage responds to exercise.

The time course and mechanisms of change in biomarkers of joint metabolism in response to acute exercise and chronic training in physiologic and pathological conditions

“…The substantial variability in the response to drop jumps is likely to be related to protocol differences as well as the participants studied, i.e., the greatest increase (+30.9%) was found in sedentary individuals. Following a typical lower body resistance exercise bout in healthy individuals, COMP responded in a similar manner to walking exercise of the same duration (Roberts et al 2018). Overall, the response of COMP across exercise modalities is generally similar, especially when assessing the response following walking, resistance training, and drop jumps (Fig.…”

“…Of the aforementioned biomarkers, the acute response of serum hyaluronan has received the most attention, perhaps a result of its promise as a biomarker of osteoarthritis. In healthy individuals, neither an acute bout of walking or resistance training increased concentration of hyaluronan (Roberts et al 2018). This supports an early study by Engström-Laurent et al (1987) who also found no evidence of a change in hyaluronan following moderate-intensity cycling, although a bout of heavy cycling exercise resulted in a significant increase in hyaluronan.…”

“…However, this was not a universal finding, as in healthy individuals, prolonged walking on an incline has been associated with a decrease in hyaluronan concentration compared to prolonged walking on the flat (Pruksakorn et al 2013). The difference between the acute loading-induced response between COMP and hyaluronan indicates that these markers reflect different joint processes, with acute loading having a more pronounced effect on COMP than hyaluronan (Roberts et al 2018). However, this may also reflect differences in the transport across the joint membrane and into the systemic circulation, and/or in the clearance of biomarkers.…”

Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review

“…The levels of HA did not vary in marathoners, soccer players, and walkers [47,75]. Increased levels of COMP were reported in marathoners and walkers [52,[66][67][68]75], but remained unchanged in cyclists and volleyball players [53,54]. In soccer players [76,77], training induced fluctuations in the serum COMP levels during a competitive season.…”

Short-term Response of Serum Cartilage Oligomeric Matrix Protein to Different Types of Impact Loading Under Normal and Artificial Gravity

“…COMP consists of five identical glycoprotein subunits and is an extracellular cartilage matrix protein, interacting with collagen molecules to maintain the network ( Halász et al, 2007 ). Enhanced serum COMP levels have been reported in different joint diseases, like osteoarthritis ( Petersson et al, 1998 ; Clark et al, 1999 ), rheumatoid arthritis ( Lindqvist et al, 2005 ; Wisłowska and Jabłońska, 2005 ), and knee injuries ( Dahlberg et al, 1994 ), but also in response to physical activity ( Pruksakorn et al, 2013 ; Cattano et al, 2017 ; Roberts et al, 2018 ). For example, serum COMP concentration rises due to cyclic exercise after 30 min of walking ( Mündermann et al, 2005 ).…”