Short-term Response of Serum Cartilage Oligomeric Matrix Protein to Different Types of Impact Loading Under Normal and Artificial Gravity

Dreiner, Maren; Willwacher, Steffen; Krämer, Andreas; Kümmel, Jakob; Frett, Timo; Zaucke, Frank; Liphardt, Anna‐Maria; Grüber, Markus; Niehoff, Anja

doi:10.3389/fphys.2020.01032

Cited by 15 publications

(8 citation statements)

References 70 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different types of exercise that target not only the cardiovascular system but also muscle and bone would probably be more suitable, for example the high-intensity jump training that proved to be very effective in maintaining muscle, bone and cardiovascular health in a previous long-term bed rest study (Kramer et al 2017a ). It was already demonstrated that jumping whilst being centrifuged is possible, albeit with reduced peak ground reaction forces and changes in the movement pattern that might lower the countermeasure efficacy (Dreiner et al 2020 ; Kramer et al 2020a ; Frett et al 2020 ). Hence, future studies are needed to (a) determine those exercise regimes that could be combined with AG exposure, and (b) disentangle the effects observed in studies combining centrifugation and exercise by comparing the effects of the combined intervention to the effects of exercise alone.…”

Section: Discussionmentioning

confidence: 99%

“…The DLR short-arm human centrifuge has a radius of 3.8 m [for a schematic representation of the centrifugation see Fig. 2 , for more details on the system see previous publications using this centrifuge (Kramer et al 2020a ; Dreiner et al 2020 )]. The participant's position with respect to the center of rotation as well as the rotational speed of the centrifuge were adjusted to achieve an acceleration of 1 g at the estimated center of mass and approximately 2 g at the feet.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Daily 30-min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT

et al. 2021

Self Cite

View full text Add to dashboard Cite

Purpose Spaceflight impairs physical capacity. Here we assessed the protective effect of artificial gravity (AG) on aerobic exercise capacity and muscle function during bed rest, a spaceflight analogue. Methods 24 participants (33 ± 9 years, 175 ± 9 cm, 74 ± 10 kg, 8 women) were randomly allocated to one of three groups: continuous AG (cAG), intermittent AG (iAG) or control (CTRL). All participants were subjected to 60 days of six-degree head-down tilt bed rest, and subjects of the intervention groups completed 30 min of centrifugation per day: cAG continuously and iAG for 6 × 5 min, with an acceleration of 1g at the center of mass. Physical capacity was assessed before and after bed rest via maximal voluntary contractions, cycling spiroergometry, and countermovement jumps. Results AG had no significant effect on aerobic exercise capacity, flexor muscle function and isometric knee extension strength or rate of force development (RFD). However, AG mitigated the effects of bed rest on jumping power (group * time interaction of the rmANOVA p < 0.001; iAG − 25%, cAG − 26%, CTRL − 33%), plantar flexion strength (group * time p = 0.003; iAG − 35%, cAG − 31%, CTRL − 48%) and plantar flexion RFD (group * time p = 0.020; iAG − 28%, cAG − 12%, CTRL − 40%). Women showed more pronounced losses than men in jumping power (p < 0.001) and knee extension strength (p = 0.010). Conclusion The AG protocols were not suitable to maintain aerobic exercise capacity, probably due to the very low cardiorespiratory demand of this intervention. However, they mitigated some losses in muscle function, potentially due to the low-intensity muscle contractions during centrifugation used to avoid presyncope.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Daily 30-min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…This might also explain the observed difference in the extent of increase between jumping and running when specific biomarkers (COMP and MMP-3) were tested. For running exercise (~ 2422 impacts per leg), the number of impacts per leg was almost tenfold higher than for jumping exercise (~ 254 impacts per leg) 44 . In addition, between each jumping series, which lasted approximately 12 s, a resting period of approximately 75 s was included, and regeneration or compensation of the biomarker concentration may occur even during this relatively short resting period, resulting in a less measurable increase in serum concentration compared to running exercise.…”

Section: Discussionmentioning

confidence: 84%

Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals

Dreiner

Munk

Zaucke

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The effect of physical activity on serum cartilage biomarkers is largely unknown. The purpose of the study was to systematically analyze the acute effect of two frequently used exercise interventions (running and jumping) on the correlation of seven serum biomarkers that reflect cartilage extracellular matrix metabolism. Fifteen healthy male volunteers (26 ± 4 years, 181 ± 4 cm, 77 ± 6 kg) participated in the repeated measurement study. In session 1, the participants accomplished 15 × 15 series of reactive jumps within 30 min. In session 2, they ran on a treadmill (2.2 m/s) for 30 min. Before and after both exercise protocols, four blood samples were drawn separated by 30 min intervals. Serum concentrations of seven biomarkers were determined: COMP, MMP-3, MMP-9, YKL-40, resistin, Coll2-1 and Coll2-1 NO2. All biomarkers demonstrated an acute response to mechanical loading. Both the COMP and MMP-3 responses were significantly (p = 0.040 and p = 0.007) different between running and jumping (COMP: jumping + 31%, running + 37%; MMP-3: jumping + 14%, running + 78%). Resistin increased only significantly (p < 0.001) after running, and Coll2-1 NO2 increased significantly (p = 0.001) only after jumping. Significant correlations between the biomarkers were detected. The relationships between individual serum biomarker concentrations may reflect the complex interactions between degrading enzymes and their substrates in ECM homeostasis.

show abstract

“…As an alternative to human centrifugation, the use of chronic artificial gravity in large rotating platforms to counteract microgravity pathologies is connected to several engineering challenges, but likely seems to be the most physiological solution [ 91 , 92 ]. In short arm human centrifuges, exposure to artificial gravity alone without further exercise is not sufficient to maintain the muscle mass, but studies testing the combined effects of artificial gravity and exercise are currently conducted [ 93 , 94 , 95 ]. Dreiner et al [ 93 ] studied the effect of different types of impact loading under normal and artificial gravity conditions on serum COMP concentrations.…”

Section: Countermeasuresmentioning

confidence: 99%

“…In short arm human centrifuges, exposure to artificial gravity alone without further exercise is not sufficient to maintain the muscle mass, but studies testing the combined effects of artificial gravity and exercise are currently conducted [ 93 , 94 , 95 ]. Dreiner et al [ 93 ] studied the effect of different types of impact loading under normal and artificial gravity conditions on serum COMP concentrations. Under Earth gravity, jumping and running resulted in a significantly higher increase in COMP serum level 30 min after impact loading than impact loading under artificial gravity.…”

Section: Countermeasuresmentioning

confidence: 99%

Joint Cartilage in Long-Duration Spaceflight

2022

View full text Add to dashboard Cite

This review summarizes the current literature available on joint cartilage alterations in long-duration spaceflight. Evidence from spaceflight participants is currently limited to serum biomarker data in only a few astronauts. Findings from analogue model research, such as bed rest studies, as well as data from animal and cell research in real microgravity indicate that unloading and radiation exposure are associated with joint degeneration in terms of cartilage thinning and changes in cartilage composition. It is currently unknown how much the individual cartilage regions in the different joints of the human body will be affected on long-term missions beyond the Low Earth Orbit. Given the fact that, apart from total joint replacement or joint resurfacing, currently no treatment exists for late-stage osteoarthritis, countermeasures might be needed to avoid cartilage damage during long-duration missions. To plan countermeasures, it is important to know if and how joint cartilage and the adjacent structures, such as the subchondral bone, are affected by long-term unloading, reloading, and radiation. The use of countermeasures that put either load and shear, or other stimuli on the joints, shields them from radiation or helps by supporting cartilage physiology, or by removing oxidative stress possibly help to avoid OA in later life following long-duration space missions. There is a high demand for research on the efficacy of such countermeasures to judge their suitability for their implementation in long-duration missions.

show abstract

Short-term Response of Serum Cartilage Oligomeric Matrix Protein to Different Types of Impact Loading Under Normal and Artificial Gravity

Cited by 15 publications

References 70 publications

Daily 30-min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT

Daily 30-min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT

Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals

Joint Cartilage in Long-Duration Spaceflight

Contact Info

Product

Resources

About