The Effect of Aerobic Training on Some Bone Formation Markers (Osteocalcin, Alkaline Phosphatase) in Asthma Treated with Inhaled Corticosteroids

Ghasemalipour, Hassan; Eizadi, Mojtaba

doi:10.5812/zjrms.58477

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…The cause of this discrepancy is not clear, but the inclusion of intensity as a FITT component might be important because intensity induces a BMD increase and, thus, is a primary influence on the extent of the training effect [ 43 ]. Currently, the optimal intensity level for interval exercise to enhance BMD in dogs is not known [ 39 ], but in humans, the proper endurance exercise intensity has been estimated to be 55–75% of HR max [ 44 ]. In this study, the mean HR during the workout stage was 158.2 bpm, and the dogs continued to exercise for 36 min for 12 weeks.…”

Section: Discussionmentioning

confidence: 99%

Effects of Interval Exercise Training on Serum Biochemistry and Bone Mineral Density in Dogs

Lee

Kim

et al. 2021

Animals

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Exercise has been suggested as a powerful intervention for health care and fitness management in humans; however, few studies have demonstrated the benefits of exercise training in dogs. The purpose of this study was to examine the effects of exercise training on heart rate (HR), bone mineral density (BMD), muscle volume (MV), and hematological and serum biomarkers in dogs. Six healthy beagles completed the interval treadmill exercise, developed on the basis of the FITT principle, two times a week for 12 weeks. To evaluate the physiological parameters, the HR values were analyzed using the Polar H10 system during the entire exercise period. At pre-and post-exercise, quantitative computed tomography and hematological and serum biochemical parameters were analyzed. The interval exercise resulted in a normal HR response and no adverse behavioral or physiological effects on the dogs. We showed that exercise improved BMD in the femur (541.6 ± 16.7 vs. 610.2 ± 27.8 HA, p < 0.01) and increased serum total alkaline phosphatase (TALP; 68.6 ± 9.2 vs. 81.3 ± 17.2, p < 0.01), aspartate aminotransferase (23.5 ± 1.0 vs. 33.5 ± 1.6, p < 0.01), and creatine kinase (114.8 ± 5.3 vs. 214.0 ± 20.8, p < 0.01) levels. There was a positive relationship between BMD and TALP (femur: r = 0.760, p = 0.004; vertebrae: r = 0.637; p = 0.025). Our findings suggest that interval exercise training is beneficial to increase BMD in the femur, and an increased TALP level would be a concomitant mechanism for enhancing BMD with exercise in dogs.

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Section: Discussionmentioning

confidence: 99%

Effects of Interval Exercise Training on Serum Biochemistry and Bone Mineral Density in Dogs

Lee

Kim

et al. 2021

Animals

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“…The cause of this discrepancy is not clear, but the inclusion of intensity as a FITT component might be important because intensity induces a BMD increase and, thus, is a primary in uence on the extent of training effect 33 . Currently, the optimal intensity level for interval exercise to enhance BMD in dogs is not known 31 , but in humans, the proper endurance exercise intensity has been estimated to 55-75% of HR max 34 . In this study, the mean HR during the workout stage was 158.2 bpm, and the dogs continued to exercise for 36 minutes for twelve weeks.…”

Section: Discussionmentioning

confidence: 99%

Increased Total Serum Alkaline Phosphate Is Associated With Enhanced Bone Mineral Density in Dogs With Interval Exercise Training

Lee¹,

Oh²,

Kim³

2021

Preprint

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There are growing attention and interdisciplinary efforts for One Health to attain optimal health and well-being for humans and animals. Exercise has been suggested as a powerful intervention for health care and fitness management in humans; however, few studies have demonstrated the beneficial effect of exercise on dogs. The purpose of this study was to examine the effects of exercise training on heart rate (HR), bone mineral density (BMD), muscle volume (MV), and hematological and serum biomarkers in dogs. Six healthy beagles completed the interval treadmill exercise protocol, developed based on the FITT principle, two times a week for 12 weeks. For a physiological parameter evaluation, the mean HR value was analyzed using a Polar H10 system and software program. Quantitative computed tomography was used to determine BMD in the femur and vertebrae and MV in the thigh before and after exercise training. To perform hematological and serum biochemical parameter assessment, blood samples were analyzed at zero and 12 weeks of exercise. We show that interval exercise results in a normal HR response and no adverse behavioral and physiological effects on dogs. Exercise improves BMD in the femur (541.6 ± 16.7 vs. 610.2 ± 27.8 HA, p < 0.01) and increases serum total alkaline phosphatase (TALP; 68.6 ± 9.2 vs. 81.3 ± 17.2, p < 0.01), aspartate aminotransferase (23.5 ± 1.0 vs. 33.5 ± 1.6, p <0.01), and creatine kinase (114.8 ± 5.3 vs. 214.0 ± 20.8, p < 0.01) levels. There is a positive relationship between BMD and TALP (femur: r = 0.760, p = 0.004; vertebrae: r = 0.637; p = 0.025). Our findings suggest that long-term interval exercise training is beneficial to increase BMD in the femur, and an increased TALP level is a concomitant mechanism for enhancing BMD with exercise in dogs.

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“…The most important mechanism of exercise is to increase osteoblasts activity and the storage of calcium and osteocalcin in the bone matrix (17). However, exercise intensity and duration are factors that can affect OC so that 12 weeks of endurance training significantly increased OC in elderly women with osteoporosis (18) maximum heart rate reserve did not have a significant effect on OC in elderly women with osteoporosis (19); however, endurance training with 75% of the maximum heart rate reserve increased the OC levels (19). Hyaluronic acid enhances synovial fluid fluidity and contributes to bone cell metabolism regulation by increasing the expression of proteins such as growth factors, type I collagen, type V collagen, fibronectin, and calcitonin (20).…”

Section: Discussionmentioning

confidence: 99%

Effect of Training, Hyaluronic Acid, and Mesenchymal Stem Cell Therapies on Osteocalcin Gene Expression in Cartilage Tissue of Rats with Knee Osteoarthritis

et al. 2019

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Background: Osteoarthritis (OA) is one of the most common progressive diseases in the joints. A few studies have evaluated the effect of combined endurance training (ET), hyaluronic acid (HA), and mesenchymal stem cells (MSCs) on bone mass. Objectives: The present study aimed to examine the effect of ET, HA, and MSCs on osteocalcin (OC) gene expression in cartilage tissues of rats with knee OA. Methods: In this experimental study, 40 rats with OA were divided into eight groups of five rats, including (1) control, (2) MSCs, (3) HA, (4) ET, (5) HA + MSCs, (6) ET + HA, (7) ET + MSCs, and (8) ET + MSCs + HA. To investigate the effects of OA on OC, five rats were assigned to the healthy group. During eight weeks, the ET groups ran on a treadmill three sessions per week (30 -50 min at a speed of 16 m/min), the MSC groups received MSCs (1 × 10 6 cells/kg) intra-articularly, and the HA groups were treated with a 10 mg/mL intra-articular therapeutic dose of HA. The OC gene expression levels were measured by the real-time PCR method. The Shapiro-Wilk and one-way ANOVA with Tukey's post hoc tests were used to analyze the data (P ≤ 0.05). Results: Osteoarthritis significantly decreased OC (P ≤ 0.05); nevertheless, ET + HA + MSCs, HA + MSCs, ET + HA, and ET + MSCs significantly increased OC (P ≤ 0.05). Also, OC was significantly higher in the ET + HA + MSCs group than in either of ET, HA, or MSC groups (P ≤ 0.05). Conclusions:It seems that a combination of ET, HA, and MSCs has more favorable effects than each one alone on the improvement of OC in cartilage tissues of rats with knee OA.

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The Effect of Aerobic Training on Some Bone Formation Markers (Osteocalcin, Alkaline Phosphatase) in Asthma Treated with Inhaled Corticosteroids

Cited by 5 publications

References 29 publications

Effects of Interval Exercise Training on Serum Biochemistry and Bone Mineral Density in Dogs

Effects of Interval Exercise Training on Serum Biochemistry and Bone Mineral Density in Dogs

Increased Total Serum Alkaline Phosphate Is Associated With Enhanced Bone Mineral Density in Dogs With Interval Exercise Training

Effect of Training, Hyaluronic Acid, and Mesenchymal Stem Cell Therapies on Osteocalcin Gene Expression in Cartilage Tissue of Rats with Knee Osteoarthritis

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