The effect of adrenalin, ephedrine, and amphetamine on the tone of the coronary vessels and the oxygen absorption of the myocardium in the heart isolated by the langendorf principle

Kisin, I. E.; Buyanov, V. V.

doi:10.1007/bf00798826

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Isolated Heart1

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1976

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“…A polarizing source, adjusted to 0.6 V, and a recording device were connected between the reference electrode and the cathode. The oxygen electrode was calibrated by Krebs solution with known oxygen content (for details see Kisin & Buyanov, 1963). Chloracyzine (0.2 or 0.5 mg) was injected into the aortic root through a catheter.…”

Section: Isolated Heartmentioning

confidence: 99%

On the Decrease of Myocardial Oxygen Consumption Induced by Chloracyzine

Kisin

1976

British J Pharmacology

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1The effects of chloracyzine (2-chloro-10-(3-diethylaminopropionyl)-phenothiazine hydrochloride; antianginal drug) on myocardial oxygen consumption were studied in open-chest cats and cat isolated hearts using oximetry and polarography respectively. 2 It was found that chloracyzine produced a decrease in myocardial oxygen consumption accompanied by a reduction in coronary blood flow preceded by transient coronary dilatation. Chloracyzine produced an insignificant increase in arterial pressure; heart rate increased slightly in the open-chest experiments but not in the isolated heart. 3 It is suggested that reduced oxygen uptake after chloracyzine is realized through improved efficiency in the use of oxygen.

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Section: Isolated Heartmentioning

confidence: 99%

On the Decrease of Myocardial Oxygen Consumption Induced by Chloracyzine

Kisin

1976

British J Pharmacology

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show abstract

The effect of adrenalin, ephedrine, and amphetamine on the tone of the coronary vessels and the oxygen absorption of the myocardium in the heart isolated by the langendorf principle

Cited by 1 publication

References 8 publications

On the Decrease of Myocardial Oxygen Consumption Induced by Chloracyzine

On the Decrease of Myocardial Oxygen Consumption Induced by Chloracyzine

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