On the Decrease of Myocardial Oxygen Consumption Induced by Chloracyzine

Kisin, I. E.

doi:10.1111/j.1476-5381.1976.tb10395.x

Cited by 2 publications

(1 citation statement)

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“…Under these conditions, papaverine aggravated the ischaemic pattern ( Figure 6). For comparison chloracyzine (which reduces myocardial oxygen demand, Kisin, 1976) was administered under the same experimental conditions; no deterioration resulted and there was even a slight tendency to normalization.…”

Section: Coronary Artery Ligationmentioning

confidence: 99%

Acute Myocardial Ischaemia in Anaesthetized Cats: Effects of Papaverine

Kisin

1978

British J Pharmacology

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1 The effects of papaverine on coronary blood flow, myocardial oxygen consumption, myocardial oxygen tension and the ischaemic ECG pattern were studied in anaesthetized open-chest cats representing three models of acute coronary insufficiency: ligation, spasm, and perfusion of the coronary artery at a stabilized insufficient level. 2 Despite the increase in myocardial oxygen consumption reflecting elevation of oxygen demand, papaverine improved the signs of myocardial ischaemia (the myocardial oxygen tension and ECG pattern), as long as there was a possibility of an increase in blood supply to the affected zone. Where this was excluded, the symptoms were actually aggravated. 3 The results suggest that there is no basis for dividing coronary dilators into 'benign' and 'malignant' according to their ability to increase myocardial oxygen requirements. A coronary dilator enhancing oxygen demand may prove beneficial even following complete coronary artery occlusion.

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Section: Coronary Artery Ligationmentioning

confidence: 99%