The Effect of Adrenal Cortical and Pituitary Adrenotropic Hormones on Transplanted Leukemia in Rats

Murphy, James B.; Sturm, Ernest

doi:10.1126/science.99.2572.303

Cited by 57 publications

(6 citation statements)

References 1 publication

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“…These tumors did not spontaneously regress, but instead shrunk when exposed to Compound E, otherwise known as cortisone [3]. A similar effect was observed in rats [4]. The increased catabolism observed at the time was thought to be responsible for the consumption of the tumor.…”

Section: Lymphoid Cancersmentioning

confidence: 88%

Glucocorticoids and Cancer

Pufall¹

2015

Advances in Experimental Medicine and Biology

167

116

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Unlike other steroid hormone receptors, the glucocorticoid receptor (GR) is not considered an oncogene. In breast cancer, the estrogen receptor (ER) drives cell growth, proliferation, and metastasis, and the androgen receptor (AR) plays a similar role in prostate cancer. Accordingly, treatment of these diseases has focused on blocking steroid hormone receptor function. In contrast, glucocorticoids (GCs) work through GR to arrest growth and induce apoptosis in lymphoid tissue. Glucocorticoids are amazingly effective in this role, and have been deployed as the cornerstone of lymphoid cancer treatment for decades. Unfortunately, not all patients respond to GCs and dosage is restricted by immediate and long term side effects. In this chapter we review the treatment protocols that employ glucocorticoids as a curative agent, elaborate on what is known about their mechanism of action in these cancers, and also summarize the palliative uses of glucocorticoids for other cancers.

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Section: Lymphoid Cancersmentioning

confidence: 88%

Glucocorticoids and Cancer

Pufall¹

2015

Advances in Experimental Medicine and Biology

167

116

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“…Astatinsll, which is the last member of the halogen group of elements, has been found to be accumulated by the thyroid glands of experimental animals to a degree similar to that of iodine131 (1)(2)(3)(4). Since the average energy of the alpha-particles arising from the disintegration of At211 is 6.8 Mev and the range in tissue is but 70p, the degree of specific ionization produced as compared to the betaparticles from 1131 is much greater.…”

Section: Figmentioning

confidence: 99%

Retardation of Growth of Implants of Carcinoma 755 in Cortisone-Injected Mice

Antopol

Glaubach

Graff

1954

Experimental Biology and Medicine

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“…According to ob servations in experimental leukaemia hypertrophy (and possibly hyperfunction) of the adrenal cortex often accompanies the development of leukaemia in animals (1)(2)(3)(4)(5)(6)(7). In human leukaemia several authors have studied the urinary excretion of adrenal steroids (8)(9)(10)(11)(12)(13)(14)(15)(16); a survey of their results seems to permit the conclusion that in the chronic leuk aemias at least, no significant deviation of the adrenocortical function has been demon strated.…”

Section: Discussionmentioning

confidence: 99%