Retardation of Growth of Implants of Carcinoma 755 in Cortisone-Injected Mice

Antopol, William; Glaubach, Susi; Graff, Samuel

doi:10.3181/00379727-86-21099

Cited by 7 publications

(3 citation statements)

References 2 publications

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“…At the actual moment no definite statements can be made as to this. Retardation of growth of transplantable tumours has been supposed to be due to a change in the environment of the tumour and more specifically to the delay in new blood vessel formation (Antopol, Glaubach and Graff, 1954). In our work the action of cortisone was made to begin only about 4 to 6 months after grafting.…”

Section: Discussionmentioning

confidence: 87%

On the Influence of Cortisone on the Evolution of Tumoural Growth in Intrasplenic Ovarian Grafts in Two Strains of Mice

Lipschütz¹,

Mardones²

1956

Br J Cancer

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CORTISONE which counteracted local growth of a transplanted non-metastasizing adenocarcinoma in mice stimulated production of metastases of the same tumour (Agosin et al., 1952). The finding of the Chilean group has been corroborated in work with other transplantable adenocarcinomata (Baserga and Shubik, 1954; Molamut, Spain, Gault and Kreisler, 1952). In the work with the transplantable Krebs-II adenocarcinoma cortisone produced widespread metastases beyond the lung filter, but no such result was obtained with Sarcoma 37 (Pomeroy, 1954). Likewise, cortisone did not affect the incidence, time of appearance or dclistribution of the anatomic sites of metastases of other transplantable tumours (Kaliss, Borges and Day, 1954;Martinez and Bittner, 1955).It seemed of considerable interest to study the question whether cortisone may stimulate production of metastases of a tumour not transplanted but originating in the body under certain experimental conditions as in the hormonal imbalance established with intrasplenic ovarian grafts. As known from the work of Biskind and Biskind (1944) with rats, of Li and Gardner (1947) and many others with mice, and of our group with guinea-pigs (Lipschutz et al., 1946; Iglesias, Mardones and Lipschutz, 1953;Mardones, Iglesias and Lipschutz, 1955) granulosa cell tumours, luteomata or mixed tumours originate under these experimental conditions (literature of work with the different species see Lipschutz, 1956). These tumours produce metastases which occur in mice (Furth and Sobel, 1947; Li, 1948) but are seemingly very rare in the rat and have been seen only once in the guinea-pig (Mardones, Iglesias and Lipschutz, 1955), almost five years after transplantation. In mice metastases occur sooner than that; but in the strains with which we shall deal in the present paper metastases in the liver have never been found earlier than 404 days after transplantation. All these statements recommend the intrasplenic ovarian tumour as very suitable for the study of the influence cortisone may exert on production of metastases of tumours originating under experimental conditions. Two strains kept in this laboratory have been used in the present work: C57bl and Balb A. Both were brought from the United States, kept for several years in the Institute of General Biology of the School of Medicine and from there they were introduced several years ago into our Institute. Operation was performed at the age of 32 to 120 days in females and at 43 to 76 days in males of C57bl; age at operation varied in Balb A between 36 and 111 days. But age at operation was always uniform in the two comparative cortisone and non-cortisone groups. The animals were ovariectomized and one of the two ovaries, cut into various

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Section: Discussionmentioning

confidence: 87%

On the Influence of Cortisone on the Evolution of Tumoural Growth in Intrasplenic Ovarian Grafts in Two Strains of Mice

Lipschütz¹,

Mardones²

1956

Br J Cancer

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“…Simpson, 1947;Simpson, 1950;Balitzky, 1950;Podilchak, 1951;Kraul, 1955) and acceleration of the development of spontaneous mammary tumours in mice (Lacassagne, Loiseleur and Rudali, 1957a, b) after injections of the testicular extracts or of purified hyalyronidase preparations. However, many other investigators (Tanzer, 1932;Prime and Haagensen, 1934;Coman et al, 1947; Arnesen, Buxton and Dulaney, 1949;Seifter and Warren, 1950;Luhrs and Willig, 1952) did not observe any influence of hyaluronidase on the growth of tumour grafts or even describe inhibitory effect.…”

Section: Invasive Growth Of Non-malignant Tissuesmentioning

confidence: 96%

“…The suggestion has been put forward therefore that this connective tissue proliferation is favourable for initial spread of malignant cells from grafted tumour fragments (Devic, et al, 1950;Vasiliev, 1955Vasiliev, , 1958a. It is probable that suppression of the initial inflammation and of the following connective tissue proliferation is one of the main causes of the inhibitory action of cortisone on the growth of transplanted homologous tumours which has been observed by a number of authors (Heilman and Kendall, 1944;Antopol, Glaubach and Graff, 1954;Higgins and Bennet, 1952;Martinez and Bittner, 1955;Selye, 1955;Vasiliev, 1958a). Inhibition of the invasion of the connective tissue by carcinomatous cells from tumour fragment grafted to cortisone-treated mice have been confirmed by histological examination (Antopol, Glaubach and Graff, 1954;Vasiliev, 1958a).…”

Section: Invasive Growth Of Non-malignant Tissuesmentioning

confidence: 97%