The effect of adding intrathecal magnesium sulphate to bupivacaine–fentanyl spinal anaesthesia

Özalevli, M.; Çetin, Taha; Ünlügenç, H.; Güler, Tayfun; Işik, G.

doi:10.1111/j.1399-6576.2005.00793.x

Cited by 104 publications

(110 citation statements)

References 23 publications

(26 reference statements)

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“…Similar findings were observed in other studies. 17,[21][22][23] Among these studies, two studies 17,23 compared magnesium sulphate as adjuvant to intrathecal bupivacaine where as in the other two studies 21,22 intrathecal fentanyl was also added and concluded the same. The duration of motor block was same in both the groups in another study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of two different doses of magnesium sulphate for spinal anaesthesia: a prospective, randomized double-blind study

et al. 2017

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Background: The present study aim was designed to compare and evaluate the efficacy of adding two different doses of magnesium sulphate to 0.5% hyperbaric levobupivacaine for spinal anaesthesia in terms of block characteristics, haemodynamic and safety profile.Methods: Ninety American Society of Anaesthesiologist (ASA) grade I-II patients undergoing elective infra-umbilical surgeries under spinal anaesthesia were randomly allocated into three groups. Group C (n=30, control group) received 3 mL (15 mg) of 0.5% hyperbaric levobupivacaine; Group M50 (n=30): received 3 mL (15 mg) of 0.5% hyperbaric levobupivacaine + 50 mg of magnesium sulphate. Group M100 (n=30) received 3 mL (15 mg) of 0.5% hyperbaric levobupivacaine + 100 mg of magnesium sulphate. A standard protocol was followed after which a blinded observer assessed the sensory and motor blocks. The onset and duration of sensory (pin-prick) block, onset, intensity and duration of motor block were recorded.Results: All the subarachnoid blocks were adequate. The addition of magnesium sulphate to intrathecal levobupivacaine had not only increased the time to onset of sensory block (p=0.007) but also prolonged the duration of sensory (p<0.001) and motor block (p<0.001) to statistically significant level in a dose dependent manner. Conclusions:Addition of magnesium sulphate does not offer any further advantage in terms of haemodynamic stability. However, it certainly increases the duration of sensory block to a significant level.

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Section: Discussionmentioning

confidence: 99%

Comparison of two different doses of magnesium sulphate for spinal anaesthesia: a prospective, randomized double-blind study

et al. 2017

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“…(4)(5)(6) Trials with intrathecal and epidural magnesium administration have shown that magnesium is a valuable adjuvant analgesic, but very few data are available on its analgesic effects in lung resection surgery. (7)(8)(9)(10) The aim of the present study was to assess effects of continuous epidural magnesium infusion during thoracic surgery on intraoperative sufentanil consumption and postoperative analgesic requirements during first 48 hours after surgery.…”

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confidence: 99%

Effects of epidural magnesium sulphate on intraoperative sufentanil and postoperative analgesic requirements in thoracic surgery patients

Kogler

Karaman-Ilić

Hrabač

et al. 2016

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“…Magnezyum pür analjezik etkili olmamakla birlikte, N-metil-D-aspartat (NMDA) reseptör antagonisti olarak medulla spinaliste ağrının işlenmesi ve modülasyonunda rol oynamaktadır. Bu etkileri ile intratekal uygulanan MgSO 4 'ın opiyoidlerin analjezik etkisini değiştire-bildiği kliniğimizde yapılan bir çalışma ile daha önce gösteril-miştir (4). Ayrıca ratlarda iv olarak uygulanan magnezyumun karaciğer mikrozomal enzim indüksiyonu yaparak amid yapıdaki lokal anestetiklerin etkisini kısalttığı da gösterilmiştir (5).…”

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“…Ayrıca ratlarda iv olarak uygulanan magnezyumun karaciğer mikrozomal enzim indüksiyonu yaparak amid yapıdaki lokal anestetiklerin etkisini kısalttığı da gösterilmiştir (5). Ancak preeklamptik gebelerde spinal anestezi sırasın-da uygulanan bupivakainin etkinliği üzerine iv uygulanan MgSO 4 'ın etkisi ile ilgili çalışma mevcut değildir.…”

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The Effect of Intravenous Magnesium Sulphate Treatment on the Spinal Anaesthesia Produced by Bupivacaine in Pre-eclamptic Patients

Atci¹,

Ünlügenç²,

Güneş³

et al. 2015

Turk J Anesth Reanim

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Objective: In our study, the effect of intravenous magnesium sulphate in normal and pre-eclamptic patients on spinal anaesthesia produced by bupivacaine was investigated.Methods: Sixty-four pregnant (32 normal and 32 pre-eclamptic) were accepted in this study. Pregnants were divided into four groups as patients given intravenous magnesium sulphate and as control. Spinal anaesthesia was induced with 12.5 mg 0.5% hyperbaric bupivacaine. Intraoperative and postoperative haemodynamic variables, sensorial block periods, onset times of sensorial and motor block, maximum sensorial block levels, the time to reach maximum block level, Bromage scores, consumptions of intraoperative analgesic and ephedrine, the quality of anaesthesia, the duration of spinal anaesthesia and magnesium levels in blood and cerebrospinal fluid were measured and recorded. Results:The level of magnesium in blood and cerebrospinal fluid was significantly higher in the group given magnesium in pre-eclamptic patients (p<0.01). Onset of sensory block times were significantly longer in intravenous magnesium group than in groups 1, 2 and 3 (p<0.05). Onset of motor block times were significantly longer and the duration of anaesthesia was shorter in groups given magnesium (p<0.05). Although the quality of anaesthesia was similar, supplemental analgesic consumption was significantly higher in pre-eclamptic pregnants given magnesium sulphate than in pre-eclamptic pregnants who were not given magnesium sulphate (p<0.05). Conclusion:Intravenous magnesium sulphate treatment during the spinal anaesthesia produced by bupivacaine extended the onset of sensory and motor block times, shortened the duration of spinal anaesthesia and therefore led to early analgesic requirement.Key Words: Spinal anaesthesia, magnesium sulphate, bupivacaine, pre-eclampsia Amaç: Çalışmamızda normal ve preeklamptik gebelerde intravenöz magnezyum sülfat tedavisinin bupivakain ile oluşturulan spinal anesteziye etkileri araştırıldı.Yöntemler: Çalışmamıza 32 normal sağlıklı, 32 preeklamptik toplam 64 gebe alındı. Olgular; intravenöz magnezyum sülfat tedavisi alan ve almayan olmak üzere toplam 4 gruba ayrıldı. Tüm gruplara 12,5 mg %0,5 hiperbarik bupivakain ile spinal anestezi uygulandı. İntraoperatif ve postoperatif hemodinamik değişkenler, sensoryal blok süreleri, sensoryal ve motor blok başlama süreleri, maksimum sensoryal blok seviyesi ve maksimum blok seviyesine ulaşma süreleri, bromage skorunun gerileme süreleri, intraoperatif analjezik ve efedrin gereksinimleri, anestezi kalitesi ve spinal anestezi süreleri ile kan ve beyin-omurilik sıvısı (BOS) magnezyum düzeyleri ölçülerek kaydedildi. Bulgular:Kan ve BOS magnezyum düzeyleri, magnezyum tedavisi alan preeklamptik gebelerde almayan gruplara göre önemli derecede yüksek bulundu (p<0,01). Sensoryal blok başlama zamanı grup intravenözde (IV) grup 1, 2 ve 3'e göre istatistiksel olarak önemli derecede uzun bulundu (p<0,05). Motor blok başlangıç sürelerinin magnezyum tedavisi uygulanan gruplarda önemli derecede uzun, anestezi sürelerinin ise...

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The effect of adding intrathecal magnesium sulphate to bupivacaine–fentanyl spinal anaesthesia

Cited by 104 publications

References 23 publications

Comparison of two different doses of magnesium sulphate for spinal anaesthesia: a prospective, randomized double-blind study

Comparison of two different doses of magnesium sulphate for spinal anaesthesia: a prospective, randomized double-blind study

Effects of epidural magnesium sulphate on intraoperative sufentanil and postoperative analgesic requirements in thoracic surgery patients

The Effect of Intravenous Magnesium Sulphate Treatment on the Spinal Anaesthesia Produced by Bupivacaine in Pre-eclamptic Patients

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