The Effect of Acute Yellow Atrophy on Metabolism and on the Composition of the Liver

Stadie, William C.

doi:10.1001/archinte.1920.00090350120009

Cited by 41 publications

(8 citation statements)

References 10 publications

(1 reference statement)

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“…This proportion is comparable to that found in normal urine (21) (27,28) and are not considered pertinent to the present study.…”

Section: Case Summariessupporting

confidence: 81%

“…Experimental attempts to demonstrate a correlation between the aminoaciduria and the plasma amino nitrogen concentration were unsuccessful. There would appear to be no similarity between the aminoaciduria occurring here and that found in acute yellow atrophy of the liver in which the plasma amino acid concentration may be greatly elevated (27,28).…”

Section: Case Summariesmentioning

confidence: 68%

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Investigation of the Aminoaciduria in Wilson's Disease (Hepatolenticular Degeneration): Demonstration of a Defect in Renal Function 1

Cooper¹,

Eckhardt²,

Faloon³

et al. 1950

J. Clin. Invest.

102

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“…This proportion is comparable to that found in normal urine (21) (27,28) and are not considered pertinent to the present study.…”

Section: Case Summariessupporting

confidence: 81%

Section: Case Summariesmentioning

confidence: 68%

Investigation of the Aminoaciduria in Wilson's Disease (Hepatolenticular Degeneration): Demonstration of a Defect in Renal Function 1

Cooper¹,

Eckhardt²,

Faloon³

et al. 1950

J. Clin. Invest.

102

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“…Earlier studies demonstrated normal urine values in chronic hepatitis, cirrhosis, infectious and toxic jaundice (18,19). In the advanced stages of acute yellow atrophy a rise in the blood amino acid level and urinary excretion rates has been reported (18)(19)(20)(21). It was suggested that this was presumably due to lack of deamination.…”

Section: Resultsmentioning

confidence: 99%

Urinary Excretion of Amino Acids in Liver Disease 1

Dunn¹,

Akawaie²,

Yeh³

et al. 1950

J. Clin. Invest.

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Previous studies from the authors' laboratories have established the range of values for the urinary excretion of 15 amino acids by normal males and females (1, 2). A preliminary survey of the urinary excretion of tryptophane, histidine, and cystine in a variety of disease states, including liver disease, showed that almost one-half of the values were either higher or lower than those observed in the control series (3). Because of the abnormalities encountered in this study, and the known relationship of the liver to amino acid metabolism (4-6), further investigation has been made into the urinary excretion of amino acids in liver disease. The present report is a study of the urinary excretion of amino acids by 25 patients, the majority of whom had subacute or chronic cirrhosis. METHODSThe previously described methods (1-3, 7, 8) were employed for the preparation of the urine samples and the determination of amino acids by microbiological assay. The probable accuracy of the amino acid data is indicated by average deviations from the mean which averaged 5 (3.7-6.7) per cent for the values at the different levels of the samples. The serum albumin and globulin fractions and total protein were performed by the methods of Kingsley (9); the blood non-protein-nitrogen by the method of Peters and Van Slyke (10); the carbon dioxide combining power by the method of Van Slyke, Stillman, and Cullen (11); the blood sugar by the method of Benedict (12), and the prothrombin time by the Quick method (13). RESULTS

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“…Only in complete hepatectomy (25) or severe liver damage (20) as in acute yellow atrophy (26)(27)(28) are amino acid values increased. The low glycine found in our case of subacute yellow atrophy might be referable to inability to synthesize this "non-essential" amino acid or to malnutrition, as suggested by the low plasma glycine observed in chronic ulcerative colitis with malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Studies on Amino Acid Metabolism. Ii. Blood Glycine and Total Amino Acids in Various Pathological Conditions, With Observations on the Effects of Intravenously Administered Glycine 1

Vries¹,

Alexander²,

Quamo³

1948

J. Clin. Invest.

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The Effect of Acute Yellow Atrophy on Metabolism and on the Composition of the Liver

Cited by 41 publications

References 10 publications

Investigation of the Aminoaciduria in Wilson's Disease (Hepatolenticular Degeneration): Demonstration of a Defect in Renal Function 1

Investigation of the Aminoaciduria in Wilson's Disease (Hepatolenticular Degeneration): Demonstration of a Defect in Renal Function 1

Urinary Excretion of Amino Acids in Liver Disease 1

Studies on Amino Acid Metabolism. Ii. Blood Glycine and Total Amino Acids in Various Pathological Conditions, With Observations on the Effects of Intravenously Administered Glycine 1

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