Studies on Amino Acid Metabolism. Ii. Blood Glycine and Total Amino Acids in Various Pathological Conditions, With Observations on the Effects of Intravenously Administered Glycine 1

Studies on Amino Acid Metabolism. Iii. Plasma Glycine Concentration and Hippuric Acid Formation Following the Ingestion of Benzoate 1

“…The net decrease in plasma glycine following benzoate administration may be influenced not only by uptake by the liver but also by other factors such as plasma volume, and by the rate of replacement of plasma glycine by tissue stores of the amino acid, In this respect it is noteworthy that the subject of Experiment 9 had an exceptionally low body weight and, accordingly probably a low plasma volume. Furthermore, an intravenous glycine tolerance test on this subject (reported elsewhere [15]) indicated a slow equilibration of plasma glycine with the tissues. It should be pointed out, however, that because of the low body weight 6 gms.…”

Studies in Para-Aminohippuric Acid Synthesis in the Human: Its Application as a Liver Function Test

“…Low plasma glycine levels have been reported in rheumatoid arthritis, chronic ulcerative colitis, and some cases of thyrotoxicosis, although uncommonly in the latter (17). The pronounced increase in PAH synthesis of the patient with thyrotoxicosis (No.…”

The Levels of Individual Free Amino Acids in the Plasma of Normal Man at Various Intervals After a High-Protein Meal1

“…That intravenously administered amino acids are rapidly removed by the tissues from the blood stream of the dog was shown many years ago by Van Slyke and Meyer (1,37). In man, also, intravenously administered glycine, methionine and lysine have been found to disappear rapidly (38)(39)(40). When the diet is the source of the additional amino acids, the liver assumes particular importance in their disposal.…”