1970
DOI: 10.1007/bf00687666
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The effect of acute arterial hypertension on the blood-brain barrier to protein tracers

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Cited by 210 publications
(59 citation statements)
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“…50 -53 Alternatively, autoregulation can be diminished or lost under pathologic conditions such as traumatic brain injury and stroke. 54,55 The loss of autoregulation decreases CVR, a result that produces hyperperfusion, BBB disruption, and vasogenic edema formation, 5,[51][52][53]56 the underlying cause of the neurologic symptoms of hypertensive encephalopathy and eclampsia. 5,56 One of the most pronounced cardiovascular adaptations that occurs during pregnancy is that maternal cardiac output and plasma volume increase by 40% to 50% by midgestation.…”
Section: Cerebral Hemodynamics During Pregnancy and Eclampsiamentioning
confidence: 99%
“…50 -53 Alternatively, autoregulation can be diminished or lost under pathologic conditions such as traumatic brain injury and stroke. 54,55 The loss of autoregulation decreases CVR, a result that produces hyperperfusion, BBB disruption, and vasogenic edema formation, 5,[51][52][53]56 the underlying cause of the neurologic symptoms of hypertensive encephalopathy and eclampsia. 5,56 One of the most pronounced cardiovascular adaptations that occurs during pregnancy is that maternal cardiac output and plasma volume increase by 40% to 50% by midgestation.…”
Section: Cerebral Hemodynamics During Pregnancy and Eclampsiamentioning
confidence: 99%
“…This syndrome is characterized by an acute rise in blood pressure that overcomes cerebral artery myogenic tone, causing forced dilatation, autoregulatory breakthrough, and hyperperfusion (21). As a consequence, blood-brain barrier disruption occurs, followed by cerebral edema formation (18). Because of the significant involvement of the cerebrovasculature in mediating these symptoms, investigating how pregnancy and hypertension during pregnancy affect the cerebral circulation seems critical to understanding and treating eclampsia.…”
mentioning
confidence: 99%
“…15 ' 16 It may explain why Grubb and coworkers" could raise the mean blood pressure in rhesus monkeys to about 180 mm Hg without any rise in the blood volume of subcortical brain tissue; on the contrary, a continuous decrease in subcortical cerebral blood volume was found during rising blood pressure, as expected when autoregulation is effective.…”
Section: Discussionmentioning
confidence: 97%