1976
DOI: 10.1161/01.str.7.3.287
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Studies on the cerebral circulation of the baboon in acutely induced hypertension.

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Cited by 39 publications
(7 citation statements)
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References 22 publications
(11 reference statements)
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“…Within a physiological range, a moderate in crease or decrease in cerebral perfusion pressure is accom panied by reciprocal changes in cerebrovas cular resistance, resulting in a constant CBF (Lassen, 1959;Purves, 1972). In spite of this "au toregulatory" mechanism, acute hemodynamic and metabolic changes under certain circumstances may temporarily or permanently alter cerebral cir culation (Harper, 1966;Freeman and Ingvar, 1968;Strandgaard et aL, 1976). Physical exercise elicits a succession of physiological reactions that are known to influence CBF, such as an increase in cardiac output and mean blood pressure and a de crease in peripheral resistance (Sture-Bevegard and Shepherd, 1967).…”
mentioning
confidence: 99%
“…Within a physiological range, a moderate in crease or decrease in cerebral perfusion pressure is accom panied by reciprocal changes in cerebrovas cular resistance, resulting in a constant CBF (Lassen, 1959;Purves, 1972). In spite of this "au toregulatory" mechanism, acute hemodynamic and metabolic changes under certain circumstances may temporarily or permanently alter cerebral cir culation (Harper, 1966;Freeman and Ingvar, 1968;Strandgaard et aL, 1976). Physical exercise elicits a succession of physiological reactions that are known to influence CBF, such as an increase in cardiac output and mean blood pressure and a de crease in peripheral resistance (Sture-Bevegard and Shepherd, 1967).…”
mentioning
confidence: 99%
“…This general similarity in the actions (both electrical and mechanical) of these 2 drugs suggests that, even if the direct action of angiotensin at lower doses is weak or negligible, the possibility of synergistic action with the norepinephrine released by the extra sympathetic activity occurring under these conditions should not be entirely overlooked. Despite earlier reports of absence of effects in vivo at very low doses, 22 - 23 angiotensin II has been found to have significant contractile effects on cerebral arteries in vitro 7 ' 8> 24t 25 and recently in vivo. 26 We believe that experiments testing physiological mechanisms in the cerebral circulation under the effects of high perfusion pressure induced by angiotensin should be interpreted viewing the cerebrovascular activity of this peptide.…”
Section: 5min I5mmhg_mentioning
confidence: 76%
“…Normal cerebral blood flow (CBF) remains relatively constant despite dramatic changes in systemic blood pressure. Subsequent experimental work, however, suggested that hypertensive encephalopathy results not from overregulation but underregulation or breakthrough of circulatory response, with a consequent increase in the CBF that results in cerebral edema [14]. In hypertensive encephalopathy cerebral autoregulation is deranged such that CBF may be adversely affected by severe hypertension.…”
Section: Hypertensive Encephalopathymentioning
confidence: 99%