The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents

Sun, Bo; Wakame, Koji; Sato, Eri; Nishioka, Hiroshi; Aruoma, Okezie I.; Fujii, H.

doi:10.1016/j.canep.2009.07.006

Cited by 17 publications

(14 citation statements)

References 67 publications

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“…This has been based on the assertion that the compound is derived from an edible mushroom 3 . In general, most experimental studies have used the oral and/or intraperitoneal (IP) route (in animal studies) with dose‐lethality determinations completed in both male and female rats 10 . The median lethal dose (LD50) in male and female rats is 8.5 g/kg and 9.8 g/kg for oral administration, respectively, and 7.4 g/kg and 8.3 g/kg for IP administration 11 …”

Section: Introductionmentioning

confidence: 99%

An Evidence‐Based Review of a Lentinula edodes Mushroom Extract as Complementary Therapy in the Surgical Oncology Patient

Shah¹,

Walker²,

Moore-Olufemi

et al. 2011

J Parenter Enteral Nutr

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The purpose of this review is to present the currently published evidence regarding the use, efficacy, potential mechanisms of action, and results of published clinical trials regarding the use of a Lentinula edodes mushroom-derived extract (active hexose correlated compound) as complementary therapy in patients with cancer. The authors explore the current preclinical and clinical evidence as it relates to this topic and its potential use in the surgical oncology patient. There has been a growing interest in stimulation of the immune system in trauma, cancer, and surgical patients in general. Little, however, has been written about some-of the supplements in widely used in Japan and China, but relatively unheard of in the United States.

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Section: Introductionmentioning

confidence: 99%

An Evidence‐Based Review of a Lentinula edodes Mushroom Extract as Complementary Therapy in the Surgical Oncology Patient

Shah¹,

Walker²,

Moore-Olufemi

et al. 2011

J Parenter Enteral Nutr

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“…In previous research, AHCC was shown to improve liver enzymes through the modulation of pro-and anti-inflammatory cytokines (12,13). In rats with hapten-induced colitis, AHCC administration reduced pro-inflammatory cytokines, including TNF and IL-1b, as well as colonic inflammation (13).…”

Section: Discussionmentioning

confidence: 92%

“…AHCC increased detoxification enzymes in the liver and protected the liver from CCl4 2 (27) and ferric nitrilotriactate (Fe-NTA)-induced injury (28). AHCC administration normalized elevated liver enzyme levels in 6-mercaptopurine and methotrexate-induced liver injury in mice (12). In humans, AHCC intake improved the levels of AST and g-GT in postoperative hepatocellular carcinoma patients (18).…”

Section: Discussionmentioning

confidence: 96%

“…AHCC is an enzyme-fermented extract of the Basidiomycetes mushroom that is available as a dietary supplement. The complex compound contains a mixture of polysaccharides, amino acids, lipids, and minerals (12). The predominant components are oligosaccharides, totaling approximately 71.2% of the total dry weight (12).…”

Section: Methodsmentioning

confidence: 99%

“…The active ingredients of AHCC are a-glucan, acetylated a-glucan, and b-glucan of polysaccharides (12). It has been suggested that AHCC has anti-oxidative (11), anti-inflammatory (12,13) and immunostimulatory effects (14,15) as well as hepatoprotective properties in vitro (16,17) and in vivo (12).…”

mentioning

confidence: 99%

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Effect of Active Hexose Correlated Compound (AHCC) in Alcohol-Induced Liver Enzyme Elevation

Kim

2014

J Nutr Sci Vitaminol

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SummaryTo investigate the effects of Active Hexose Correlated Compound (AHCC) supplementation and the mechanism action of AHCC in patients with alcohol-induced mildly elevated liver enzyme levels, participants were randomly allocated to the placebo, 1 g AHCC, or 3 g AHCC group and took the supplement for 12 wk. Subjects visited the hospital for clinical and biochemical measurements, for examination of adverse events, to return unused supplements, and to obtain their next supplements. Biochemical tests including liver enzymes, a questionnaire survey, and anthropometric measurements were collected at baseline and every 4 wk thereafter. Adherence and adverse events were evaluated. After 12 wk of supplementation, the percentage change in alanine aminotransferase (ALT) level was significantly different between the placebo (4.02659.07%) and both AHCC groups (1 g AHCC: 223.89620.59%, 3 g AHCC: 224.09630.73%) (p50.04). Serum levels of tumor necrosis factor-a (p,0.05) and interleukin-1b (p,0.01) were significantly lower, while those of adiponectin were higher in both AHCC groups than in the placebo group (p,0.01). AHCC supplementation for 12 wk may improve the levels of liver enzymes and circulating pro-inflammatory and anti-inflammatory cytokines in patients with alcohol-induced liver enzyme elevation with mildly elevated liver enzyme levels.

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Medicinal Mushrooms: Cultivation and Pharmaceutical Impact

Cheong

Tan²,

Fung

2018

Fungal Biology

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The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents

Cited by 17 publications

References 67 publications

An Evidence‐Based Review of a Lentinula edodes Mushroom Extract as Complementary Therapy in the Surgical Oncology Patient

An Evidence‐Based Review of a Lentinula edodes Mushroom Extract as Complementary Therapy in the Surgical Oncology Patient

Effect of Active Hexose Correlated Compound (AHCC) in Alcohol-Induced Liver Enzyme Elevation

Medicinal Mushrooms: Cultivation and Pharmaceutical Impact

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