1975
DOI: 10.1007/bf01347973
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The effect of acetylethyleneimine upon a strain of inactivated foot-and-mouth disease virus stored at 4� C

Abstract: The presence of either thiosulphate-neutralized or free AEI was shown to degrade inactivated foot-and-mouth disease virus Type O (Hong Kong) antigen during storage at 4 degrees C. Deterioration was evident after 20 weeks of storage and little antigen remained at 36 weeks. Optimum stability was obtained by removing the residual inactivant immediately after inactivation.

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Cited by 5 publications
(3 citation statements)
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References 10 publications
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“…Thus, observations on FMDV vaccines and specific cases of unstable virus strains such as Kenya 227/66 (6, 9) and ttong Kong (14) are consistent with the general pattern of the data presented here. It would seem worthwhile to investigate the thermal stabilities of other strains of FMD virus, particularly those which give relatively poor protection as vaccines.…”
Section: Thermal Stabilities Of 75 S Particlessupporting
confidence: 92%
See 1 more Smart Citation
“…Thus, observations on FMDV vaccines and specific cases of unstable virus strains such as Kenya 227/66 (6, 9) and ttong Kong (14) are consistent with the general pattern of the data presented here. It would seem worthwhile to investigate the thermal stabilities of other strains of FMD virus, particularly those which give relatively poor protection as vaccines.…”
Section: Thermal Stabilities Of 75 S Particlessupporting
confidence: 92%
“…This conclusion is substantiated by the work of ROWLANDS et al (9) and MOWAT et al (6) with the SAT2 serotype virus, Kenya 227/66, and STAPLE et al (14) with the "0" serotype virus, 0 Hong Kong. Their results indicate that inactivation with AEI reduced the stabilities of these viruses and, consequently, the potencies of the corresponding vaccines.…”
Section: Tr Doel and 1 ) J Baccar~isupporting
confidence: 62%
“…Foot-and-mouth disease virus has been inactivated in cell culture fluids when exposed to a chemical agent, 2-bromo-ethylene-imine (BEI) (2,3,5,18). Influenza and mumps viruses have been inactivated by physical means through gamma-particle irradiation from a "°Co source t Journal paper no.…”
mentioning
confidence: 99%