The effect of Acellularized Wharton's Jelly-derived exosomes on myeloid differentiation of umbilical cord blood-derived CD34+ hematopoietic stem cells

Abbaszadeh, Hossein; Ghorbani, Farzaneh; Derakhshani, Mehdi; Abbasi, Batoul; Jalili, Zahra; Talebi, Mehdi; Yousefi, Mehdi; Shamsasenjan, Karim; Edalati, Mahdi; Hakimi, Parvin; Sanei, Maryam; Yaghoubi, Reza; Movassaghpour, Ali Akbar

doi:10.1016/j.genrep.2021.101298

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Consequently, this cause restoration of the cytoskeleton, by cleaving the actin protein network and finally budding occur Fig. 1 [58][59][60][61].…”

Section: Extracellular Vesicles Overviewmentioning

confidence: 99%

Shining the light on mesenchymal stem cell-derived exosomes in breast cancer

Al-Awsi¹,

Alsaikhan

Margiana

et al. 2023

Stem Cell Res Ther

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In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and development. Multiple researches have demonstrated that MSCs can favor tumor growth, while other groups have indicated that MSCs inhibit tumor development. Emerging evidences showed exosomes (Exo) as a new mechanism of cell communication which are essential for the crosstalk between MSCs and BC cells. MSC-derived Exo (MSCs-Exo) could mimic the numerous effects on the proliferation, metastasis, and drug response through carrying a wide scale of molecules, such as proteins, lipids, messenger RNAs, and microRNAs to BC cells. Consequently, in the present literature, we summarized the biogenesis and cargo of Exo and reviewed the role of MSCs-Exo in development of BC.

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“…Consequently, this cause restoration of the cytoskeleton, by cleaving the actin protein network and finally budding occur Fig. 1 [58][59][60][61].…”

Section: Extracellular Vesicles Overviewmentioning

confidence: 99%

Shining the light on mesenchymal stem cell-derived exosomes in breast cancer

Al-Awsi¹,

Alsaikhan

Margiana

et al. 2023

Stem Cell Res Ther

View full text Add to dashboard Cite

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The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles

Ortiz

Zaidi

Saini

et al. 2023

International Immunopharmacology

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Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases

et al. 2022

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The autoimmune diseases are associated with the host immune system, chronic inflammation, and immune reaction against self-antigens, which leads to the injury and failure of several tissues. The onset of autoimmune diseases is related to unbalanced immune homeostasis. Mesenchymal stem cells (MSCs) are multipotent cells which have capability to self-renew and differentiate into various cell types that exert a critical role in immunomodulation and regenerative therapy. Under the certain condition in vitro, MSCs are able to differentiate into multiple lineage such as osteoblasts, adipocytes, and neuron-like cells. Consequently, MSCs have a valuable application in cell treatment. Accordingly, in this review we present the last observations of researches on different MSCs and their efficiency and feasibility in the clinical treatment of several autoimmune disorders including rheumatoid arthritis, type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, autoimmune liver disease, and Sjogren’s syndrome.

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The effect of Acellularized Wharton's Jelly-derived exosomes on myeloid differentiation of umbilical cord blood-derived CD34+ hematopoietic stem cells

Cited by 3 publications

References 28 publications

Shining the light on mesenchymal stem cell-derived exosomes in breast cancer

Shining the light on mesenchymal stem cell-derived exosomes in breast cancer

The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles

Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases

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