The effect of acebutolol on the cerebral circulation of man.

Hares, Pamela; Im, James; Griffith, D N

doi:10.1111/j.1365-2125.1977.tb00727.x

Cited by 24 publications

(8 citation statements)

References 5 publications

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“…It has been reported (Aoyagi et al, 1976;Hares et al, 1977) that CBF falls when ,B-adrenergic blocking drugs are administered acutely. We wondered if in a more chronic setting this might also occur and be reflected clinically in the lethargy and lightedness which are known to occur on occasion in association with these drugs (Petrie, Galloway, Jeffers & Webster, 1976).…”

Section: Discussionmentioning

confidence: 99%

“…Potentially, therefore, fiadrenergic receptor blocking drugs might reduce CBF by either or both of these mechanisms. That this does indeed occur acutely has been shown both in animals (Aoyagi, Deshmukh, Meyer, Kawamura & Tagashira, 1976;James & Macdonell, 1975b) and in man (Hares, James & Griffith, 1977). Hares et al (1977) showed a mean fall in CBF from 47.1 to 40.9 ml 100 mg-' min-' (significant at 1% level on t-testing) when acebutolol was administered by intravenous infusion in a total dose of 0.2 mg/kg to seven normal volunteers, using the same technique for CBF measurement as will be described for this study.…”

Section: Introductionmentioning

confidence: 99%

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The effect of beta‐adrenergic receptor blocking drugs on cerebral blood flow.

Griffith¹,

Im²,

Newbury³

et al. 1979

Brit J Clinical Pharma

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1 Cerebral blood flow (CBF) was measured by the 133xenon inhalation method in 33 newly‐diagnosed hypertensive patients prior to commencing therapy. 2 Blood pressure was treated by using a varying sequence of four different drugs, namely labetalol, metoprolol, oxprenolol and sotalol, each of which is a beta‐adrenergic receptor blocking agent, but with differing additional properties. 3 CBF measurements were repeated when blood pressure was controlled. No significant change in CBF was found with any of the four drugs, in contrast to the fall which has been reported when drugs of this type are administered acutely.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of beta‐adrenergic receptor blocking drugs on cerebral blood flow.

Griffith¹,

Im²,

Newbury³

et al. 1979

Brit J Clinical Pharma

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“…В одних исследованиях было показано, что кратковременная терапия β-блокаторами приводила к снижению перфузии головного мозга с развитием ишемической симпто-матики [27], в других -длительная терапия вызывала увеличение мозгового кровотока, уменьшение асим-метрии и восстановление реактивности церебраль-ных сосудов [28].…”

Section: рис 6 динамика уровня тиреоидных гормонов на фоне терапии unclassified

Modern Potential in the Treatment of Metabolic Syndrome Patients - Focus on Endothelium

Мычка¹,

Tolstov²,

Салов³

et al. 2014

Russ J Cardiol

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“…Cerebral blood flow decreases after acute administration of diazoxide (78), clonidine (79) and betablockers (80)(81).…”

Section: Treatment Of High Blood Pressure In Patientsmentioning

confidence: 99%

Blood Pressure in Acute Stroke: Causes and Consequences

Carlberg

1994

Hypertens Res

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Patients with acute stroke often have high blood pressure levels the first days after hospital admission. The causes of high blood pressure in patients with acute stroke are incompletely known. In stroke patients with large cerebral lesions and impaired consciousness, high blood pressure seems to be secondary to high intracranial pressure and in these patients high blood pressure indicates a worse prognosis. In the majority of patients, alert on hospital admission, high blood pressure increases from hospitalization stress and is not related to a worse prognosis. (Hypertens Res 1994; 17 Suppl. I: S77-S82)

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The effect of acebutolol on the cerebral circulation of man.

Cited by 24 publications

References 5 publications

The effect of beta‐adrenergic receptor blocking drugs on cerebral blood flow.

The effect of beta‐adrenergic receptor blocking drugs on cerebral blood flow.

Modern Potential in the Treatment of Metabolic Syndrome Patients - Focus on Endothelium

Blood Pressure in Acute Stroke: Causes and Consequences

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