The effect of a prostaglandin-synthetase inhibitor, naproxen sodium, and a placebo on the pain response to carbon dioxide laser treatment of the uterine cervix

Al-Kurdi, M.; Hare, M. J.; Lowles, I.; Douglas, Charles P; English, John R.

doi:10.3109/01443618509067771

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…Two small RCTs was used to evaluate oral naproxen before carbodioxide laser vaporization for preinvasive cervical cancer. Al-Kurdi et al, 1985 reported that premedication oral NSAIDs (Naproxen sodium) used in carbondioxide laser treatment of uterine cervix has minimal effect on the pain and causes discomfort during laser treatment. The likely explanation for the failure of naproxen sodium to relieve the pain during laser application may be that transmitting nerves are stimulated directly during applying the laser.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, our study confirms that pre-procedural oral Mefenamic acid before LEEP is unlikely to significantly reduce pain during LEEP excision and post LEEP at 30 minutes. Al-Kurdi et al, 1985 reported that patients suffered from some pain during laser treatment particularly from dysmenorrhea, dental drilling and parturition. However, our study indicated that the factors such as the size of loop diameter, parity, menopausal status, cervical cytological and final histological type are not associated with pain score during excision and post LEEP 30 minutes by subgroup analysis.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Mefenamic Acid in Pain Control during Loop Electrical Excision Procedure:A Prospective Double-Blind Randomized Control Trial

Dabpookhiew

Temtanakitpaisan

Kietpeerakool

et al. 2020

Asian Pac J Cancer Prev

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Objective: To investigate the effectiveness of pre-procedural oral mefenamic acid compared with placebo in women undergoing Loop Electrosurgical Excision Procedure (LEEP) with intracervical lidocaine injection. Study designs: A prospective double-blinded randomized control trial. Materials, Setting, Methods: Women undergoing LEEP for any indications were asked to participate in the study. The participants were randomly allocated into two groups. In group 1 (oral mefenamic acid), the participants were offered oral mefenamic acid (500 mg) for 30 minutes before procedures. In group 2 (placebo), the patients were given oral placebo (identical tablet) for 30 minutes before operation. All participants received immediate 10 mL of 2% lidocaine with 1:100,000 of epinephrine intracervical injection before undergoing the LEEP. All participants were excised in one piece of LEEP. No top-hat excision in this study. The patients graded their pain on a 10-cm visual analog scale (VAS) at different points during the procedure, including speculum insertion, at starting excision, and 30 minutes post excision. Primary outcomes revealed the difference of VAS during all steps of LEEP by generalized estimating equations procedure. Results: Sixty participants (30 in mefenamic group and 30 in placebo group) participated in this study. The study did not find differences of VAS during all steps of LEEP and analgesic drug requirement at 30 minutes after LEEP procedure. All patients reported no immediate complications and no intervention-related adverse events were observed. Conclusion: Using pre-procedural oral mefenamic acid before LEEP procedure was not associated with pain reduction during all steps of excision.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Mefenamic Acid in Pain Control during Loop Electrical Excision Procedure:A Prospective Double-Blind Randomized Control Trial

Dabpookhiew

Temtanakitpaisan

Kietpeerakool

et al. 2020

Asian Pac J Cancer Prev

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“…Paracervical blocks are ineffective (Johnson et al . 1989), non‐steroid anti‐inflammatory drugs have only a small effect on perceived pain (Al‐Kurdi et al . 1985) and direct infiltration of local anaesthetic reduces pain scores by 40% (Lee et al .…”

mentioning

confidence: 99%

Is transcutaneous electrical nerve stimulation of any value during cervical laser treatment?

Crompton

Johnson

Dudek

et al. 1992

BJOG

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Objective To assess the value of transcutaneous electrical nerve stimulation (TENS) during cervical laser therapy. Design Randomized three arm controlled clinical trial comparing (i) TENS, (ii) local anaesthetic and (iii) TENS plus local anaesthetic (direct infiltration of 2% lignocaine and 0.03 iu/ml octopressin). Setting Colposcopy Unit adapted to run randomized trials. Subjects 100 women with CIN and no previous experience of cervical surgery. Main outcome measure Visual linear analogue pain scores. Results The median pain score associated with TENS was greater than the score associated with local anaesthesia (23% compared with 17%; P= 0.1). Combining TENS with local anaesthesia did not further reduce pain scores. Conclusion Although there was considerable consumer satisfaction with TENS it provided no additional pain relieving effect in addition to direct infiltration of lignocaine and it is inferior to lignocaine alone. We are unable to advocate the use of TENS for laser treatment of the cervix.

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Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment

Gajjar¹,

Martin-Hirsch²,

Bryant³

2012

Cochrane Database of Systematic Reviews

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The effect of a prostaglandin-synthetase inhibitor, naproxen sodium, and a placebo on the pain response to carbon dioxide laser treatment of the uterine cervix

Cited by 7 publications

References 5 publications

Effects of Mefenamic Acid in Pain Control during Loop Electrical Excision Procedure:A Prospective Double-Blind Randomized Control Trial

Effects of Mefenamic Acid in Pain Control during Loop Electrical Excision Procedure:A Prospective Double-Blind Randomized Control Trial

Is transcutaneous electrical nerve stimulation of any value during cervical laser treatment?

Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment

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