The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: A phase I double-blind, three-way randomized cross-over clinical trial

Mohsenpour, Mohammad Ali; Kaseb, Fatemeh; Nazemian, Reza; Mozaffari‐Khosravi, Hassan; Fallahzadeh, Hossein; Salehi‐Abargouei, Amin

doi:10.1016/j.endinu.2018.12.008

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Polyols have been used as sugar replacers for about 80 years. Clinical trial showed that polyols had a role in lowering serum glucose levels in T2D patients (Mohsenpour et al, 2019), which may provide a new strategy to manage T2D. Dietary fibers, which are mainly found in cereals, fruits, vegetables, or legumes, showed close associations with T2D.…”

Section: Carbohydratementioning

confidence: 99%

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

Guo

Huang

Sang

et al. 2020

Front. Bioeng. Biotechnol.

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Type 2 diabetes (T2D) is a rapidly growing epidemic, which leads to increased mortality rates and health care costs. Nutrients (namely, carbohydrates, fat, protein, mineral substances, and vitamin), sensing, and management are central to metabolic homeostasis, therefore presenting a leading factor contributing to T2D. Understanding the comprehensive effects and the underlying mechanisms of nutrition in regulating glucose metabolism and the interactions of diet with genetics, epigenetics, and gut microbiota is helpful for developing new strategies to prevent and treat T2D. In this review, we discuss different mechanistic pathways contributing to T2D and then summarize the current researches concerning associations between different nutrients intake and glucose homeostasis. We also explore the possible relationship between nutrients and genetic background, epigenetics, and metagenomics in terms of the susceptibility and treatment of T2D. For the specificity of individual, precision nutrition depends on the person's genotype, and microbiota is vital to the prevention and intervention of T2D.

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Section: Carbohydratementioning

confidence: 99%

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

Guo

Huang

Sang

et al. 2020

Front. Bioeng. Biotechnol.

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“…Both randomised studies reported statistically significant decrease for blood glucose and one of them reported a statistically significant decrease for insulin. Mohsenpour et al., 2019 , within a single dose double‐blind randomised cross‐over trial framework, assessed the effect of three 300 mL beverages containing 50 g glucose, 50 g sucrose or 50 g lacritose (a mixture of lactose, fructose, sucrose and erythritol) respectively on postprandial serum glucose up to 2 h post‐intervention and on GI adverse effects 1 day post‐intervention ( n = 40, Iran). Study participants were adults with either type 2 diabetes ( n = 21) or healthy subjects ( n = 20).…”

Section: Extensive Literature Searchmentioning

confidence: 99%

“…Four interventional studies in humans that assessed mixtures of sweeteners including erythritol (sample size; ranging from 25 to 40 subjects) were retrieved from the literature (Fukuda et al., 2010 ; Gan et al., 2022 ; Mohsenpour et al., 2019 ; Shin et al., 2016 ). Two studies were randomised, three studies implemented a cross‐over design, and one study was a pre‐post study.…”

Section: Extensive Literature Searchmentioning

confidence: 99%

Re‐evaluation of erythritol (E 968) as a food additive

Younes,

Aquilina,

Castle

et al. 2023

EFS2

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This opinion addresses the re-evaluation of erythritol (E 968) as food additive and an application for its exemption from the laxative warning label requirement as established under Regulation (EU) No 1169/2011. Erythritol is a polyol obtained by fermentation with Moniliella pollinis BC or Moniliella megachiliensis KW3-6, followed by purifications and drying. Erythritol is readily and dose-dependently absorbed in humans and can be metabolised to erythronate to a small extent. Erythritol is then excreted unchanged in the urine. It does not raise concerns regarding genotoxicity. The dataset evaluated consisted of human interventional studies. The Panel considered that erythritol has the potential to cause diarrhoea in humans, which was considered adverse because its potential association with electrolyte and water imbalance. The lower bound of the range of no observed adverse effect levels (NOAELs) for diarrhoea of 0.5 g/kg body weight (bw) was identified as reference point. The Panel considered appropriate to set a numerical acceptable daily intake (ADI) at the level of the reference point. An ADI of 0.5 g/kg bw per day was considered by the Panel to be protective for the immediate laxative effect as well as potential chronic effects, secondary to diarrhoea. The highest mean and 95th percentile chronic exposure was in children (742 mg/kg bw per day) and adolescents (1532 mg/kg bw per day). Acute exposure was maximally 3531 mg/kg bw per meal for children at the 99th percentile. Overall, the Panel considered both dietary exposure assessments an overestimation. The Panel concluded that the exposure estimates for both acute and chronic dietary exposure to erythritol (E 968) were above the ADI, indicating that individuals with high intake may be at risk of experiencing adverse effects after single and repeated exposure. Concerning the new application, the Panel concluded that the available data do not support the proposal for exemption.

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Natural Alternative Sweeteners and Diabetes Management

Mejia

Pearlman

2019

Curr Diab Rep

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The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: A phase I double-blind, three-way randomized cross-over clinical trial

Cited by 3 publications

References 33 publications

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

Re‐evaluation of erythritol (E 968) as a food additive

Natural Alternative Sweeteners and Diabetes Management

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