The effect of a natural molecule in ovary ischemia reperfusion damage: does lycopene protect ovary?

Abstract

Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion. Oxidative stress plays a central role in the development of ischemia/reperfusion (IR) injuries. Lycopene (LYC) is a lipophilic, natural carotenoid well known for its antioxidant properties. This study provides information on the potential applications of lycopene. The Wistar Albino rats were distributed into six groups: Sham group (only a laparotomy was performed), Control group [laparotomy and intraperitoneal dissolvent (olive oil)], IR group, IR+olive oil group, IR+LYC 2.5 mg/kg/dose, intraperitoneal group, IR+LYC 5 mg/kg/dose intraperitoneal group. Evaluated in terms of histopathological changes, tissue malondialdehyde levels (MDA), ovarian expressions of phosphorylated nuclear factor-kappa B (p-NF-κB) and the TUNEL method was utilized to show apoptosis of ovarian tissue. There was a significant decrease in MDA, p-NF-κB values and the proportion of apoptotic cells assessed by TUNEL compared to the group that did not receive intraperitoneal LYC in rat injury with IR damage (P<0.05). In histopathological damage scoring, it was observed that the cell damage was significantly reduced in LYC-administered groups. LYC showed significant ameliorative effects on ovary injury caused by IR through acting as an antioxidant, antiinflammatory, and antiapoptotic agent.

The protective effect of JZL184 on ovarian ischemia reperfusion injury and ovarian reserve in rats

“…This scoring was considered as 0: no damage, 1: slightly damaged, 2: moderately damaged, 3: severely damaged. Damages such as hemorrhage and cellular shedding were involved as the scoring criteria 6 . Moreover, the amount of primordial, primary, secondary, and tertiary follicles in 10 different areas were counted.…”

“…As the clinical picture of ovarian torsion is generally nonspecific, delays in diagnosis and treatment might be experienced. Thus, the ischemia/reperfusion (IR) model has been employed in various studies, and numerous pharmacological agents have been investigated to reduce IRI 5–9 . In addition, ischemia reperfusion injury can negatively affect ovarian reserve, which is usually evaluated by anti‐Mullerian hormone (AMH) 10 .…”

“…Reperfusion injury, paradoxically, causes more damage to tissues or organs than ischemic injury 5 . To reduce post‐torsion ovarian damage, either the ischemia duration or ischemia/reperfusion injury (IRI) should be reduced 6 . As the clinical picture of ovarian torsion is generally nonspecific, delays in diagnosis and treatment might be experienced.…”

Ratlarda Deneysel Olarak Oluşturulan Renal İskemi-Reperfüzyon Hasarında Likopen ve Kafeinin Antioksidan Etkilerinin İncelenmesi

“…Lycopene protects the cell from lipid peroxidation and oxidative DNA damage due to its highly effective antioxidant properties. It also has anti-apoptotic, anti-inflammatory, anti-amyloid, anti-ischemic and antitumor properties (12). Lycopene increases ATP synthesis and ETS chain activity.…”

“…In addition, due to its high lipid solvent properties, lycopene can cross the blood-brain barrier. It is also useful for neurological diseases such as Alzheimer (10,(12)(13). Coffee is one of the most popular drinks in the world.…”