The effect of a multicomponent transitional pharmaceutical care intervention on the incidence and nature of unintentional medication discrepancies in geriatric patients after hospital discharge

Wilting, Ingeborg; Maanen, A. Clara Drenth-van; Jansen, P.A.F.; Marum, Rob J. van; Egberts, A.C.G.

doi:10.1016/j.eurger.2012.07.283

Cited by 1 publication

(4 citation statements)

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“…In total, 54 studies were included in the systematic review, including 20,895 hospital discharges across 26 countries. The included studies consisted of 41 published papers [23,24, and 13 conference abstracts [87][88][89][90][91][92][93][94][95][96][97][98][99]. One of the included conference abstracts [88] was combined with one letter to the editor [100].…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…In total, 14 studies reported data concerning the frequency of UMDs [49,50,57,59,60,66,70,74,83,84,88,93,95,98]. Three studies [83,84,93] used an established UMD definition, seven [49,50,59,60,70,74,95] developed their own and four [57,66,88,98] did not report any definition.…”

Section: Unintentional Medication Discrepancy Studiesmentioning

confidence: 99%

“…Table 4 summarises outcome rates of the included studies per patient population. [72], three ADR studies [62,64,91], nine ADE studies [24, 54-56, 61, 69, 78, 80, 94] and five UMD studies [59,66,70,88,95]. Seven studies [54,61,62,64,72,78,80] reported severity assessment based on existing rating scales published in the literature.…”

Section: Adverse Drug Eventsmentioning

confidence: 99%

“…Four studies reported that the median rate of serious ADEs was found to be 29% (IQR 21-38.5%) of adult and elderly patients experiencing one or more ADEs post-discharge [61,69,80,94]. Among patients affected by UMDs, three studies reported that between 25 and 34% of elderly patients [66,88], and 63.3% of paediatric patients were affected by moderate harm events [95]. Two studies reported that 33-38% of UMDs identified post-hospital discharge as associated with a high potential of harm in adult patients [59,70].…”

Section: Severity Of Eventsmentioning

confidence: 99%

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Prevalence and Nature of Medication Errors and Medication-Related Harm Following Discharge from Hospital to Community Settings: A Systematic Review

2020

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Background Little is known about the epidemiology of medication errors and medication-related harm following transition from secondary to primary care. This systematic review aims to identify and critically evaluate the available evidence on the prevalence and nature of medication errors and medication-related harm following hospital discharge. Methods Studies published between January 1990 and March 2019 were searched across ten electronic databases and the grey literature. No restrictions were applied with publication language or patient population studied. Studies were included if they contained data concerning the rate of medication errors, unintentional medication discrepancies, or adverse drug events. Two authors independently extracted study data. Results Fifty-four studies were included, most of which were rated as moderate (39/54) or high (7/54) quality. For adult patients, the median rate of medication errors and unintentional medication discrepancies following discharge was 53% [interquartile range 33-60.5] (n = 5 studies) and 50% [interquartile range 39-76] (n = 11), respectively. Five studies reported adverse drug reaction rates with a median of 27% [interquartile range 18-40.5] and seven studies reported adverse drug event rates with a median of 19% [interquartile range 16-24]. For paediatric patients, one study reported a medication error rate of 66.3% and another an adverse drug event rate of 9%. Almost a quarter of studies (13/54, 24%) utilised a follow-up period post-discharge of 1 month (range 2-180 days). Drug classes most commonly implicated with adverse drug events were antibiotics, antidiabetics, analgesics and cardiovascular drugs. Conclusions This is the first systematic review to explore the prevalence and nature of medication errors and adverse drug events following hospital discharge. Targets for future work have been identified.

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