The Effect of a Herbal Water-Extract on Histamine Release from Mast Cells and on Allergic Asthma

Haggag, Eman; Abou-Moustafa, Magda; Boucher, William; Theoharides, Theoharis C.

doi:10.1080/j157v03n04_03

Cited by 39 publications

(6 citation statements)

References 17 publications

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“…Haggag et al . [87] tested inhibitory effect of herbs infusion (chamomile, saffron, anise, fennel, caraway, licorice, cardamom and black seed) on histamine that was relinquished from stimulated rat peritoneal mast cells by immunoglobulin E and anti-immunoglobulin E. The results of the experiment showed that the herbs infusion restrained histamine released from chemically- and immunologically-induced cells by 81% and 85%, respectively. In comparison, quercetin appears to be more effective, as it affected histamine release by 95% and 97%, respectively.…”

Section: Polyphenols and Quercetin As Effective Anti-allergic Secomentioning

confidence: 99%

Quercetin and Its Anti-Allergic Immune Response

et al. 2016

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Abstract:Quercetin is the great representative of polyphenols, flavonoids subgroup, flavonols. Its main natural sources in foods are vegetables such as onions, the most studied quercetin containing foods, and broccoli; fruits (apples, berry crops, and grapes); some herbs; tea; and wine. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production. It can improve the Th1/Th2 balance, and restrain antigen-specific IgE antibody formation. It is also effective in the inhibition of enzymes such as lipoxygenase, eosinophil and peroxidase and the suppression of inflammatory mediators. All mentioned mechanisms of action contribute to the anti-inflammatory and immunomodulating properties of quercetin that can be effectively utilized in treatment of late-phase, and late-late-phase bronchial asthma responses, allergic rhinitis and restricted peanut-induced anaphylactic reactions. Plant extract of quercetin is the main ingredient of many potential anti-allergic drugs, supplements and enriched products, which is more competent in inhibiting of IL-8 than cromolyn (anti-allergic drug disodium cromoglycate) and suppresses IL-6 and cytosolic calcium level increase.

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Section: Polyphenols and Quercetin As Effective Anti-allergic Secomentioning

confidence: 99%

Quercetin and Its Anti-Allergic Immune Response

et al. 2016

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“…In vitro studies about the action of quercetin aglycone reported its ability to inhibit histamine release in human basophils when they are activated and also inhibit peptide presentation in antigen presenting cells 27 .Quercetin is also known as a natural inhibitor of mast cells exocytosis. It can induce the down regulation of the degranulatory response in mast cells 28 .…”

Section: Functional Properties Of Quercetinmentioning

confidence: 99%

Anti-Inflammatory Properties of Quercetin: A Review

Nweze

Tseaa

Ekpe

2022

J. Drug Delivery Ther.

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Quercetin, one of the most taken flavonoid with diet, belongs to the family of flavonols. Quercetin occurs as a glycoside or as an aglycone and is gotten from various dietary sources such as apples, berries, onions, kale. Quercetin is being reviewed based on its bioavailability, metabolism and anti-inflammatory properties. Inflammation is the body's immune response to an irritant; this could be a pathogen or foreign object. An inflammatory response is either acute or chronic depending on the duration of inflammation and prolonged inflammatory response can lead to various diseases that are harmful to the body. Studies have shown that quercetin exerts good anti-inflammatory, antioxidant and anti-allergic activity by acting on leukocytes, targeting signaling kinases as well as membrane proteins crucial for an inflammatory response and acts as a scavenger of free radicals. Quercetin also down regulates the expression of pro-inflammatory factor while up regulating the expression of anti-inflammatory factor and this aids in maintaining homeostasis. Although poorly bioavailable due to its rapid metabolism, quercetin is an effective modulator of inflammation. Keywords: Quercetin, inflammation, antioxidants, flavonols, free-radicals

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“…This was the case even at higher concentrations, suggesting that the free hydroxyl groups of quercetin ( 55 ) are all important in retaining its activity and that its substitution by methylation and glycosylation results in a lowering or loss of its activity [ 53 ]. It was also found to have a relaxant effect on guinea pig trachea pre-contracted with histamine [ 78 , 87 ] as well as in vitro inhibition of histamine release from the rat peritoneal mast cells by 95–97% [ 88 ]. This shows the therapeutic potential of quercetin ( 55 ) as a promising antiasthmatic agent.…”

Section: Biological Studies Structure–activity Relationship and Therapeutic Potentialmentioning

confidence: 99%

Flavonoids from the Genus Euphorbia: Isolation, Structure, Pharmacological Activities and Structure–Activity Relationships

et al. 2021

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Plants of the genus Euphorbia are widely distributed across temperate, tropical and subtropical regions of South America, Asia and Africa with established Ayurvedic, Chinese and Malay ethnomedical records. The present review reports the isolation, occurrence, phytochemistry, biological properties, therapeutic potential and structure–activity relationship of Euphorbia flavonoids for the period covering 2000–2020, while identifying potential areas for future studies aimed at development of new therapeutic agents from these plants. The findings suggest that the extracts and isolated flavonoids possess anticancer, antiproliferative, antimalarial, antibacterial, anti-venom, anti-inflammatory, anti-hepatitis and antioxidant properties and have different mechanisms of action against cancer cells. Of the investigated species, over 80 different types of flavonoids have been isolated to date. Most of the isolated flavonoids were flavonols and comprised simple O-substitution patterns, C-methylation and prenylation. Others had a glycoside, glycosidic linkages and a carbohydrate attached at either C-3 or C-7, and were designated as d-glucose, l-rhamnose or glucorhamnose. The structure–activity relationship studies showed that methylation of the hydroxyl groups on C-3 or C-7 reduces the activities while glycosylation loses the activity and that the parent skeletal structure is essential in retaining the activity. These constituents can therefore offer potential alternative scaffolds towards development of new Euphorbia-based therapeutic agents.

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The Effect of a Herbal Water-Extract on Histamine Release from Mast Cells and on Allergic Asthma

Cited by 39 publications

References 17 publications

Quercetin and Its Anti-Allergic Immune Response

Quercetin and Its Anti-Allergic Immune Response

Anti-Inflammatory Properties of Quercetin: A Review

Flavonoids from the Genus Euphorbia: Isolation, Structure, Pharmacological Activities and Structure–Activity Relationships

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