The effect of a dexibuprofen mouth rinse on experimental gingivitis in humans

Rosin, Michael; Kahler, S. T.; Heßler, Michael; Schwahn, Ch.; Kuhr, Alexander; Kocher, Thomas

doi:10.1111/j.1600-051x.2005.00721.x

Cited by 5 publications

(27 citation statements)

References 32 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To overcome such limitations, Rosen et al . [14] introduced an ingenious method in the form of a plaque guard. This study has drawn inspiration from Rosen's study and most of the subjects did not complain either about abstinence from oral hygiene or any discomfort from wearing the appliance.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A randomized, double‑blind clinical study to assess the antiplaque and antigingivitis efficacy of Aloe vera mouth rinse

Chandrahas

Jayakumar

Naveen

et al. 2012

J Indian Soc Periodontol

View full text Add to dashboard Cite

Aims:To evaluate the efficacy of Aloe Vera mouth rinse on experimental plaque accumulation and gingivitis.Materials and Methods:In this randomized, controlled, and double-blind study, a total of 148 systemically healthy subjects were screened in the age group of 18-25 years. Finally, 120 subjects were requested to abstain from oral hygiene (tooth brushing) for 14 days and used a specially fabricated plaque guard. Following cessation of tooth brushing in the specified area, the subjects were randomly divided into Group A (test group) who received 100% Aloe vera, Group B (negative control group) who received placebo (distilled water), and Group C (positive control group) who received 0.2% chlorhexidine. The rinse regimen began on the 15th day and continued for 7 days. Plaque accumulation was assessed by Plaque Index (PI) and gingivitis was assessed by Modified Gingival Index (MGI) and Bleeding Index (BI) at baseline (0), 7th, 14th, and 22nd days.Results:There was statistically significant decrease in PI, MGI, and BI scores after the rinse regimen began in both Group A (test group) and Group C (chlorhexidine) compared with Group B. Mouth wash containing Aloe vera showed significant reduction of plaque and gingivitis but when compared with chlorhexidine the effect was less significant.Conclusion:Aloe vera mouthwash can be an effective antiplaque agent and with appropriate refinements in taste and shelf life can be an affordable herbal substitute for chlorhexidine.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[14] The plaque guard prevented plaque removal from the experimental teeth and facilitated localized plaque accumulation and the resultant gingivitis if any [Figure 2]. …”

Section: Methodsmentioning

confidence: 99%

A randomized, double‑blind clinical study to assess the antiplaque and antigingivitis efficacy of Aloe vera mouth rinse

Chandrahas

Jayakumar

Naveen

et al. 2012

J Indian Soc Periodontol

View full text Add to dashboard Cite

show abstract

“…) and another with a cross‐over design (Rosin et al. ). Among the studies, one study had more than one experimental group that met the inclusion criteria, so the data were divided for the comparisons with the same control group (Khosravi Samani et al.…”

Section: Resultsmentioning

confidence: 99%

“…, , Rosin et al. ), whereas the remaining 10 publications studied different compounds. There was a high heterogeneity between the study groups and the type of vehicles used.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Are anti‐inflammatory agents effective in treating gingivitis as solo or adjunct therapies? A systematic review

Polak

Martín

Sanz‐Sánchez

et al. 2015

J Clinic Periodontology

View full text Add to dashboard Cite

Objective: Systematically review the scientific evidence for efficiency of antiinflammatory agents against gingivitis, either as solo treatments or adjunctive therapies. Methods: A protocol was developed aimed to answer the following focused question: "Are anti-inflammatory agents effective in treating gingivitis as solo or adjunct therapies?" RCTs and cohort studies on anti-inflammatory agents against gingivitis studies were searched electronically. Screening, data extraction and quality assessment were conducted. The primary outcome measures were indices of gingival inflammation. A sub-analysis was performed dividing the active agents into anti-inflammatory and other drugs. Results: The search identified 3188 studies, of which 14 RCTs met the inclusion criteria. The use of anti-inflammatory or other agents, in general showed a higher reduction in the test than in the control in terms of gingival indexes and bleeding scores. Only two RCTs on inflammatory drugs could be meta-analysed, showing a statistically significant reduction in the GI in the experimental group [WMD = À0.090; 95% CI (À0.105; À0.074); p = 0.000]. However, the contribution of both studies to the global result was unbalanced (% weight: 99.88 and 0.12 respectively).Conclusions: Most of the tested material showed beneficial effect as anti-inflammatory agents against gingivitis, either as a single treatment modality or as an adjunctive therapy.

show abstract

Experimental gingivitis in patients with and without altered passive eruption

Aghazada

Marini

Zeza

et al. 2019

Journal of Periodontology

View full text Add to dashboard Cite

BackgroundIndividuals with altered passive eruption (APE) are assumed to be more susceptible to periodontal diseases. To date, this hypothesis has not been sufficiently supported by scientific evidence. The aim of this study, using an experimental gingivitis model, was to examine the development and resolution of gingival inflammation in patients with APE when compared to patients with normal gingival anatomy.MethodsA localized experimental gingivitis was induced in 9 patients with APE (test group) and 9 patients without APE (control group) in the maxillary right quadrant. After 21 days, patients were instructed to resume proper home oral hygiene procedures. At baseline (day 0) and at days 7, 14, 21, 28, 35, and 42, plaque index (PlI), gingival index (GI), and gingival crevicular fluid volume (GCF) were evaluated for teeth 6 (canine), 7 (lateral incisor) and 8 (central incisor) of test and control groups.ResultsDuring the experimental gingivitis phase (days 0 to 21), the rate of change in gingival inflammation (GI) was dramatically different between the APE test group and the control group. On day 21, at the time of maximum plaque accumulation, the GI of the APE test group was a 109% greater than the GI of the test group (P ≤ 0.001) despite similar plaque levels (P = 0.436). During the resolution of inflammation phase (days 22 to 42), the APE test group continued to exhibit statistically higher GI scores than the control group (P = 0.029).ConclusionIn the presence of similar amounts of plaque deposits and plaque accumulation rates, APE patients exhibited differences in the development and resolution of plaque‐induced gingival inflammation when compared to controls.

show abstract

The effect of a dexibuprofen mouth rinse on experimental gingivitis in humans

Abstract: In the present study, a 1.5% dexibuprofen mouth rinse had no effect on gingivitis whereas an anti-plaque effect was demonstrated.

Cited by 5 publications

References 32 publications

A randomized, double‑blind clinical study to assess the antiplaque and antigingivitis efficacy of Aloe vera mouth rinse

A randomized, double‑blind clinical study to assess the antiplaque and antigingivitis efficacy of Aloe vera mouth rinse

Are anti‐inflammatory agents effective in treating gingivitis as solo or adjunct therapies? A systematic review

Experimental gingivitis in patients with and without altered passive eruption

Contact Info

Product

Resources

About