The effect of a 1-deoxynojirimycin derivative on post-prandial blood glucose and insulin levels in healthy black and white volunteers

Joubert, P. H.; Venter, C. P.; Joubert, H.F.; Hillebrand, I.

doi:10.1007/bf00607920

Cited by 23 publications

(9 citation statements)

References 5 publications

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“…In previous studies (Canderay et al 1985;Joubert et al 1985;Hillebrand et al 1986), Bay-m-1099 at doses of 25 mg or above reduced postprandial plasma glucose and insulin responses in normal volunteers; the reductions observed in the present study are comparable with those in previous studies using similar doses of Bay-m-1099, namely a greater than 50% reduction at 50 mg. Compared with Acarbose, the most widely studied glucosidase inhibitor, Bay-m-1099 appears to be similarly or somewhat more potent, since a 50 mg dose of Acarbose reduced postprandial plasma glucose and insulin responses by about 10 and 45%, respectively, whereas at 100 mg Acarbose reduced postprandial plasma glucose and insulin responses about 10 and 60%, respectively (Hillebrand et al 1979b).…”

Section: Discussionsupporting

confidence: 94%

The EFFECT OF TWO NEW Α‐GLUCOSIDASE INHIBITORS ON METABOLIC RESPONSES TO a MIXED MEAL IN NORMAL VOLUNTEERS

Kennedy

Miles

Heiling

et al. 1987

Clin Exp Pharma Physio

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1. alpha-Glucosidase inhibitors delay carbohydrate absorption and have been proposed as adjunctive therapy for diabetes mellitus. 2. To determine the effects of two new alpha-glucosidase inhibitors, Bay-m-1099 and Bay-o-1248, on meal carbohydrate and lipid tolerance, plasma glucose, insulin and triglyceride levels were measured at 15-60 min intervals over 12 h after ingestion of a standard breakfast, lunch and dinner of identical composition in 31 normal volunteers. 3. The volunteers were randomized to receive either Bay-m-1099 (50 or 25 mg) or placebo prior to each meal, or the single administration of Bay-o-1248 (20 or 10 mg) or placebo prior to breakfast. 4. Only Bay-m-1099 at the 50 mg dose reduced significantly the postprandial increase in plasma insulin levels after each meal when compared with placebo (25, 36, 54% at breakfast, lunch, and dinner, respectively; P less than 0.05). Both drugs were well tolerated, with side effects limited to complaints of flatulence. 5. Thus, with the dosage schedule employed, Bay-m-1099, but not Bay-o-1248, significantly reduced postprandial increments in plasma insulin.

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Section: Discussionsupporting

confidence: 94%

The EFFECT OF TWO NEW Α‐GLUCOSIDASE INHIBITORS ON METABOLIC RESPONSES TO a MIXED MEAL IN NORMAL VOLUNTEERS

Kennedy

Miles

Heiling

et al. 1987

Clin Exp Pharma Physio

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“…Some hypoglycemic substances were obtained from these materials. For example, Moran A, Moran 20K, and moranoline (1-deoxynojirimycin) were isolated from mulberry root bark [7,10,12]. N-containing sugars have also been found in mulberry leaves [22].…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice

et al. 2012

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Components of silk including silk fibroin have long been used as anti-diabetic remedies in oriental medicine. However, detailed mechanisms underlying these anti-diabetic effects remain unclear. In this study, we examined the anti-diabetic activity of silk fibroin hydrolysate (SFH) in C57BL/KsJ-db/db (db/db) mice, a well-known animal model of non-insulin dependent diabetes mellitus. When the db/db mice were administered SFH in drinking water for 6 weeks, hyperglycemia in the animals gradually disappeared and the level of glycosylated hemoglobin decreased, indicating that SFH plays important role in reducing the symptoms of diabetes. In addition, SFH-treated db/db mice exhibited improved glucose tolerance with increased plasma insulin levels. Immunohistochemical and morphological analyses showed that SFH up-regulated insulin production by increasing pancreatic β cell mass in the mice. In summary, our results suggest that SFH exerts anti-diabetic effects by increasing pancreatic β cell mass in a non-insulin dependent diabetes mellitus mouse model.

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“…For example, Moran A, Moran 20K, and moranoline (1-deoxynojirimycin) were isolated from mulberry root bark [19][20][21], and Ncontaining sugars were isolated from mulberry leaves [22].…”

Section: Discussionmentioning

confidence: 99%

Silk fibroin has a protective effect against high glucose induced apoptosis in HIT‐T15 cells

Park

Nam

Park

et al. 2010

J Biochem & Molecular Tox

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High glucose levels induce cell death in many cell types, including pancreatic β-cells. Although protective agents against glucotoxicity have been searched for extensively, so far none have been found. In this report, we tested silk fibroin (SF) as a candidate material for antiglucotoxicity in the pancreatic β-cell (HIT-T15 cell) line. Approximately 50% of cells were killed after treatment with 80 mg/mL glucose. This reduction of cell number was recovered by the addition of SF at 50 mg/mL. SF treatment also decreased cellular reactive oxygen species (ROS) and increased proliferating cellular nuclear antigen (PCNA) immunoreactivity. In addition, TUNEL assays demonstrated that SF protects against glucose-induced apoptosis of HIT-T15 cells, suggesting that SF might protect cells from cell death by lowering cellular ROS levels. SF also induced expression of the insulin-like growth factor-1 (IGF-1) gene, and IGF-1 expression may be the cause of SF-induced protection against glucose toxicity. Taken together, these results suggest that SF could serve as a potential therapeutic agent to treat the hyperglycemia-induced death of pancreatic β-cells.

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The effect of a 1-deoxynojirimycin derivative on post-prandial blood glucose and insulin levels in healthy black and white volunteers

Cited by 23 publications

References 5 publications

The EFFECT OF TWO NEW Α‐GLUCOSIDASE INHIBITORS ON METABOLIC RESPONSES TO a MIXED MEAL IN NORMAL VOLUNTEERS

The EFFECT OF TWO NEW Α‐GLUCOSIDASE INHIBITORS ON METABOLIC RESPONSES TO a MIXED MEAL IN NORMAL VOLUNTEERS

Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice

Silk fibroin has a protective effect against high glucose induced apoptosis in HIT‐T15 cells

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