The effect of a 0.1% cetylpyridinium chloride mouthrinse on plaque and gingivitis in adult subjects

Ashley, F P; Skinner, Annette; Jackson, P; Woods, Annette; Wilson, R.F.

doi:10.1038/sj.bdj.4805458

Cited by 26 publications

(15 citation statements)

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“…Interestingly, as in this study, no differences were noted in plaque score between active and placebo, but a significant reduction in plaque weight was found with CPC. Gingivitis was reduced in both groups, also as noted here, but in the Ashley et al 15 study to a significantly greater extent in the active group.…”

Section: Discussionsupporting

confidence: 64%

“…The antiseptic is usually used at concentrations ranging from 0.05 to 0.1% in mouthrinses. There seems to be general agreement from reviews on the subject that CPC rinses are not as effective against plaque and gingivitis as Chlorhexidine rinses.1^H owever, although not free from similar side effects to Chlorhexidine,5 the occurrence and severity of dental staining is considerably less with CPC.6 With the exception of an early study,7 data for plaque inhibition by CPC, largely, have been encouraging, but somewhat equivocal for effects on gingivitis.6 [8][9][10][11][12][13][14][15] studies have evaluated CPC rinses as adjuncts to normal oral hygiene. However, certainly 2 studies have demonstrated benefits to plaque and/or gingivitis.14,15…”

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confidence: 98%

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The Effects of a Cetylpyridinium Chloride Prebrushing Rinse as an Adjunct to Oral Hygiene and Gingival Health

Moran¹,

Addy²

1991

Journal of Periodontology

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A NUMBER OF MOUTHWASH PRODUCTS containing cetylpyridinium chloride (CPC) are available. Data for individual products are limited, although overall the antiseptic has been shown to reduce plaque. Results for gingivitis reductions by CPC have been equivocal. This study was an active/placebo parallel group design to evaluate the use of a CPC mouthrinse as an adjunct to oral hygiene when used before toothbrushing. Plaque and gingivitis scores were recorded at baseline and after 6 weeks, following twice daily use of the active or placebo prebrushing rinses. Plaque and gingivitis were significantly reduced at 6 weeks in both groups with no significant treatment differences between the active and placebo formulations. Whether the order of rinsing to toothbrushing influenced these findings cannot be determined. However, the results further question the adjunctive benefits of CPC rinses to gingival health.

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Section: Discussionsupporting

confidence: 64%

mentioning

confidence: 98%

The Effects of a Cetylpyridinium Chloride Prebrushing Rinse as an Adjunct to Oral Hygiene and Gingival Health

Moran¹,

Addy²

1991

Journal of Periodontology

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“…In reality, these results are not inconsistent with other studies investigating the gingivitis and plaque inhibitory properties of CPC and triclosan mouthrinses. Thus, studies have tended to show superior efficacy of CPC mouthrinses over placebo formulations for plaque, albeit considerably less than chlorhexidine (Volpe et al . 1969, Ciancio et al .…”

Section: Discussionmentioning

confidence: 99%

A method to compare four mouthrinses:

Yates

Shearer

Huntington

et al. 2002

J Clinic Periodontology

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“…This is related to the reported of Pizzo et al (2001). CPC mouthwash were reported to inhibit plaque formation by reducing in plaque weight, but had no effect on clinical plaque score (Hollbeche et al, 1975;Ashley et al, 1984). The prolonged use can result in severe tooth staining (Addy and Jenkins, 1977).…”

Section: Resultsmentioning

confidence: 97%

Candida inhibitory effects of six commercial mouthwashes

Aroonrerk

Dhanesuan

2007

Ann. Microbiol.

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The Candida inhibitory activities of commercial mouthwashes with various active ingredients -fluoride (FLO), cethylpyridinium chloride (CPC), chlorhexidine gluconate (CHX), triclosan (TRI) and herbal extracts: Twin Lotus (TLO) and Herbric concentrated (HBC) -were determined. The Candida activities included growth, germ tube formation and adhesion of Candida albicans to human buccal mucosa. This study showed that TRI, TLO and CHX mouthwashes had growth inhibitory effects to C. albicans with the MIC of 1/64, 1/64 and 1/32, respectively. CHX, TRI, TLO, HBC and CPC mouthwashes had ability to inhibit adhesion of C. albicans ATCC 10231 by approximately 85, 80, 70, 65 and 55%, respectively. Germ tube formation, or mycelial conversion, of C. albicans was inhibited by approximately 90, 85 and 80% after treatment with 20% mouthwashes containing CHX, TRI and CPC, respectively. Fluoride mouthwash showed the weakest in all inhibitory activities. These results suggested that CHX and triclosan mouthwashes were effective in reducing oral Candida activities.

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The effect of a 0.1% cetylpyridinium chloride mouthrinse on plaque and gingivitis in adult subjects

Cited by 26 publications

References 0 publications

The Effects of a Cetylpyridinium Chloride Prebrushing Rinse as an Adjunct to Oral Hygiene and Gingival Health

The Effects of a Cetylpyridinium Chloride Prebrushing Rinse as an Adjunct to Oral Hygiene and Gingival Health

A method to compare four mouthrinses:

Candida inhibitory effects of six commercial mouthwashes

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