The Effects of a Cetylpyridinium Chloride Prebrushing Rinse as an Adjunct to Oral Hygiene and Gingival Health

Abstract

A NUMBER OF MOUTHWASH PRODUCTS containing cetylpyridinium chloride (CPC) are available. Data for individual products are limited, although overall the antiseptic has been shown to reduce plaque. Results for gingivitis reductions by CPC have been equivocal. This study was an active/placebo parallel group design to evaluate the use of a CPC mouthrinse as an adjunct to oral hygiene when used before toothbrushing. Plaque and gingivitis scores were recorded at baseline and after 6 weeks, following twice daily use of the active or placebo prebrushing rinses. Plaque and gingivitis were significantly reduced at 6 weeks in both groups with no significant treatment differences between the active and placebo formulations. Whether the order of rinsing to toothbrushing influenced these findings cannot be determined. However, the results further question the adjunctive benefits of CPC rinses to gingival health.

Halitosis: a review of associated factors and therapeutic approach

“…A CPC rinse used in a 6-week pre-brushing study failed to confer any adjunctive benefit to oral hygiene and gingival health compared to a control rinse. 56 Although there is still debate over the action of cationic antiseptics in the oral cavity, what is clear is the lack of substantivity of cetylpyridinium chloride. This is highlighted by a persistence of antimicrobial activity of CPC in the mouth of only 3 h, which compares poorly with the greater than 12-hour action of CHX.…”

Can Alcohol Intake from Mouthwash be Measured in Epidemiological Studies? Development and Validation of Mouthwash Use Questionnaire with Particular Attention to Measuring Alcohol Intake from Mouthwash

“…Benzydamine hydrochloride acts as an analgesic, anti-inflammatory, antimicrobial and anaesthetic and is often used in mouthwash to supplement chlorhexidine gluconate. Cetylpyridinium chloride, sodium benzoate and triclosan are added to prevent plague and gingivitis, although these effects have also been questioned [4,5]. It is recommended to rinse with mouthwash containing hydrogen peroxide when suffering from acute ulcerative disease, gingivitis or to enhance oral hygiene and diminish dental staining.…”

“…It is recommended to rinse with mouthwash containing hydrogen peroxide when suffering from acute ulcerative disease, gingivitis or to enhance oral hygiene and diminish dental staining. Fluoride prevents and reduces dental caries while sodium bicarbonate protects against xerostomia and erosion [5]. Essential oils, used in mouthwash, permeate the plaque biofilm to eliminate bacteria and microorganisms and can reduce plague, gingivitis and halitosis [3].…”

Efficacy of a 0.15% benzydamine hydrochloride and 0.05% cetylpyridinium chloride mouth rinse on 4‐day de novo plaque formation

“…Classic studies with home use for 14 days revealed reductions of plaque but not of gingivitis (Ciancio et al 1978); however, a 6‐month home‐use study using a new formulation reported both plaque‐inhibitory and anti‐plaque capacity (Allen et al 1998). This discrepancy in the results can be owing to differences in formulations, and its use either before or after tooth brushing, as its use prior to tooth brushing does not seem to be useful (Moran & Addy 1991) and if used immediately after brushing with a toothpaste, its activity could be inhibited by the toothpaste formulation (Sheen et al 2003). CPC has also been evaluated in plaque re‐growth models, demonstrating limited benefits as compared with chlorhexidine mouth rinses (Jenkins et al 1994, Harper et al 1995, Moran et al 2000).…”