2021
DOI: 10.1590/s2175-979020200003181020
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The effect of 6-gingerol on biochemical and histological parameters in cholesterol-induced nonalcoholic fatty liver disease in NMRI mice

Abstract: Fatty liver contains a range of clinical symptoms, including the accumulation of fat in the liver parenchyma and it varies from a simple steatosis to non-alcoholic steatohepatitis and cirrhosis. Using natural therapies has always been a great concern for such health-related diseases. Herein, 6-gingerol, as a natural compound, was applied to treat non-alcoholic fatty liver induced in NMRI mice. The assessment included histological studies of the liver along with measurement of biochemical parameters, including … Show more

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Cited by 7 publications
(4 citation statements)
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“…Interestingly, the administration of 6-G in a dose-dependent manner could improve oxidative stress by increasing pancreatic GPx activity and reducing the pancreatic MDA levels, respectively, as compared with that of the HFHF group. It has also been demonstrated that 6-G has the capability of improving the nonalcoholic fatty liver by increasing the antioxidant enzymes, catalase, and superoxide dismutase 10 . In fact, 6-G could inhibit free radicals and lipid peroxidation, protect the liver and pancreas, and balance the oxidant and antioxidant levels 26,27 …”
Section: Discussionmentioning
confidence: 99%
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“…Interestingly, the administration of 6-G in a dose-dependent manner could improve oxidative stress by increasing pancreatic GPx activity and reducing the pancreatic MDA levels, respectively, as compared with that of the HFHF group. It has also been demonstrated that 6-G has the capability of improving the nonalcoholic fatty liver by increasing the antioxidant enzymes, catalase, and superoxide dismutase 10 . In fact, 6-G could inhibit free radicals and lipid peroxidation, protect the liver and pancreas, and balance the oxidant and antioxidant levels 26,27 …”
Section: Discussionmentioning
confidence: 99%
“…8 6-Gingerol treatment also significantly reduced the levels of triglyceride, cholesterol, glucose, insulin resistance, and leptin while increasing the levels of liver antioxidant enzymes and adiponectin. 9,10 Although 6-G has been shown to have antioxidant and antiobesity properties in numerous studies, its potential to reduce lipid accumulation in pancreatic tissues has not been investigated. Therefore, in this study, we investigated whether 6-G could be effective for ameliorating FPD in the MetS rat model.…”
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confidence: 99%
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