2023
DOI: 10.1016/j.jsps.2023.01.003
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6-gingerol ameliorates weight gain and insulin resistance in metabolic syndrome rats by regulating adipocytokines

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Cited by 4 publications
(5 citation statements)
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“…Furthermore, this study also proves that administration of HFHF causes obesity, as indicated by increased body weight, Lee's index, and accumulation of lipids in the epididymis and subcutaneous tissues. Previously, we reported that the administration of HFHF also causes insulin resistance, hyperglycemia, and hypertriglyceridemia, and all of those alterations were ameliorated by the administration of 6-G in a dose-dependent manner 9 …”
Section: Discussionmentioning
confidence: 95%
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“…Furthermore, this study also proves that administration of HFHF causes obesity, as indicated by increased body weight, Lee's index, and accumulation of lipids in the epididymis and subcutaneous tissues. Previously, we reported that the administration of HFHF also causes insulin resistance, hyperglycemia, and hypertriglyceridemia, and all of those alterations were ameliorated by the administration of 6-G in a dose-dependent manner 9 …”
Section: Discussionmentioning
confidence: 95%
“…Previously, we reported that the administration of HFHF also causes insulin resistance, hyperglycemia, and hypertriglyceridemia, and all of those alterations were ameliorated by the administration of 6-G in a dose-dependent manner. 9 Excess food energy due to the chronic administration of a high-fat diet is stored as triglycerides in adipose tissue and internal organs, including the pancreas, leading to steatosis and organ dysfunction. 18 In fact, treatment of rat islet cells with raised glucose and free fatty acids resulted in the enhancement of the size and number of lipid droplets in pancreatic β-cells, which led to insulin resistance.…”
Section: Discussionmentioning
confidence: 99%
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“…The biomarkers used to characterize the TPDM6315 extracts in this study possess anti-inflammatory, anti-obesity, and improved insulin-resistant properties. These were gallic acid [ 34 , 35 , 36 ], chebulagic acid [ 37 , 38 ], ellagic acid [ 39 , 40 , 41 ], chebulinic acid [ 42 , 43 , 44 ], phellopterin [ 45 ], and 6-gingerol [ 46 , 47 ]. The HPLC chromatogram showed the principal peaks of the gallic acid and ellagic acid, while the peaks of the chebulagic acid, chebulinic acid, phellopterin, and 6-gingerol appeared as minor peaks and needed to be further confirmed.…”
Section: Discussionmentioning
confidence: 99%