The effect of 25-hydroxyvitamin D levels on QT interval duration and dispersion in type 2 diabetic patients

Yetkin, Demet Özgil; Küçükkaya, Belgin; Turhan, Mehtap Sultan; Ören, Merve Meryem

doi:10.3325/cmj.2015.56.525

Cited by 10 publications

(12 citation statements)

References 28 publications

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“…Vitamin D deficiency has been related to different cardiovascular disorders, including SCD [ 86 ]. Moreover, a decreased level of 25-OHD has been linked to structural and ionic channel remodeling, which may increase arrhythmic events [ 87 ]. Indeed, prolonged QTc is commonly induced by hypocalcemia, which can be caused by vitamin D inadequacy or resistance.…”

Section: Vitamin Dmentioning

confidence: 99%

Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome

et al. 2021

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A healthy regime is fundamental for the prevention of cardiovascular diseases (CVD). In inherited channelopathies, such as Brugada syndrome (BrS) and Long QT syndrome (LQTS), unfortunately, sudden cardiac death could be the first sign for patients affected by these syndromes. Several known factors are used to stratify the risk of developing cardiac arrhythmias, although none are determinative. The risk factors can be affected by adjusting lifestyle habits, such as a particular diet, impacting the risk of arrhythmogenic events and mortality. To date, the importance of understanding the relationship between diet and inherited channelopathies has been underrated. Therefore, we describe herein the effects of dietary factors on the development of arrhythmia in patients affected by BrS and LQTS. Modifying the diet might not be enough to fully prevent arrhythmias, but it can help lower the risk.

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Section: Vitamin Dmentioning

confidence: 99%

Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome

et al. 2021

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“…As well as those who suggest that there is no relationship between vitamin D and QT intervals (41) that vitamin D defi ciency prolongs QT intervals and thus can lead to arrhythmias (42). In patients with low vitamin D, which is accompanied by symptoms such as type 2 diabetes, the QT interval was found to be prolonged as a marker of ventricular repolarization abnormality (43). In individuals taking antiepileptic drugs that cause vitamin D defi ciency, the QT interval has been shown to grow (42).…”

Section: Discussionmentioning

confidence: 99%

Effects of serum vitamin D level on ventricular repolarization in children and adolescents

Bekdaş¹,

İnanır²,

Ilhan³

et al. 2021

BLL

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OBJECTIVES: Low levels of vitamin D are known to increase cardiovascular mortality due to different risks. We aimed to examine whether low vitamin D levels in children and adolescents cause ventricular repolarization changes. METHODS: Sixtyseven healthy cases aged between 3.5 and 17 years were included. According to levels of vitamin D, cases were grouped as suffi cient (n=44), insuffi cient (n=13) and defi ciency (n=10). Ventricular repolarization parameters were measured manually. RESULTS: Levels of vitamin D were different for cases with insuffi ciency and defi ciency compared to suffi ciency ones (102±54.9 vs 24.4±7 ng/ml, p<0.001 and 102±54.9 vs 16.6±8.3 ng/ml, respectively, p<0.001). In the insuffi cient group the following parameters were different from suffi cient group: QTmean (357.8±25.3 vs 332±29.9 ms, p=0.012), JTc (310.8±20.2 vs 331.6±21 ms, p=0.005) and Tpe/QT (0.2±0.02 vs 0.22±0.02, p=0.02). It was found that the level of serum vitamin D correlated with JTc (r=-0.37, p=0.002), Tp-e (r=-0.29, p=0.015) and Tp-e/QT (r=-0.24, p=0.047). In the linear regression analysis, it was found that dropping level of vitamin D below normal was an independent risk factor for prolonged duration of JTc (p=0.015). CONCLUSIONS: Decline in vitamin D levels causes ventricular repolarization anomaly. As the decrease in vitamin D levels deepens, repolarization times become longer. These results could indicate that decrease in vitamin D levels can increase sensitivity to ventricular arrhythmias (Tab. 3, Ref. 45).

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“…In fact, very little is known about the relationship between cQT and 25(OH)D with contrasting results. Nalbant et al demonstrated that there is no difference in cQT between people with normal levels of 25(OH)D and those with low levels of 25(OH)D [57]; on the other hand, prolonged cQT duration and cQT dispersion have been observed in patients with vitamin D deficiency [57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population

Capuano

Marchese

Sica

et al. 2021

Journal of Nutrition and Metabolism

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Background. Vitamin D (25(OH)D) deficiency is a prevalent condition worldwide. However, the highest prevalence rates of 25(OH)D deficiency have been attributed to regions with higher latitude. A close association between 25(OH)D and cardio-cerebrovascular (CCV) risk factors and major health problems has been identified. Aim. To establish the prevalence of 25(OH)D deficiency and to investigate the relationship between 25(OH)D levels and CCV risk factors (blood cholesterol, triglycerides, glucose concentrations, body mass index, and systolic and diastolic blood pressure) in a cohort representative of Southern Italy. Methods. The prevalence of 25(OH)D levels was evaluated in 1200 subjects aged 25–74 years (600 males and 600 females), enrolled in the “VIP” (from Italian for Irno Valley Prevention) Project, whereas multiple linear regression analysis was used to determine the relationship between 25(OH)D levels and CCV risk factors. Results. Only 13.3% of females and 11.1% of males showed adequate serum concentrations of 25(OH)D (≥30 ng/ml), while 59.3% of females and 55.1% of males showed 25(OH)D deficient levels (<20 ng/ml). We observed an independent association between 25(OH)D concentrations and metabolic syndrome score, LDL cholesterol, HDL cholesterol, and corrected QT (cQT). Conclusions. We report a high prevalence of 25(OH)D deficiency across the largest Italian adult population studied so far and, in particular, the first across Southern Italy; furthermore, we provide data on the association between 25(OH)D deficiency and higher CCV risk factors.

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The effect of 25-hydroxyvitamin D levels on QT interval duration and dispersion in type 2 diabetic patients

Cited by 10 publications

References 28 publications

Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome

Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome

Effects of serum vitamin D level on ventricular repolarization in children and adolescents

Epidemiologic Data of Vitamin D Deficiency and Its Implication in Cardio-Cerebrovascular Risk in a Southern Italian Population

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