The Effect of 2 Sympatholytic Medications—Propranolol and Clonidine—On Sleep Bruxism: Experimental Randomized Controlled Studies

Huynh, Nelly; Lavigne, Gilles; Lanfranchi, Paola; Montplaisir, Jacques; Champlain, Jacques de

doi:10.1093/sleep/29.3.307

Cited by 98 publications

(96 citation statements)

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“…Although the hypothesis has been formulated that GABA may play a role in SB, any relationship seems to be merely indirect, since GABA is implicated in almost all the neuronal systems that control wakefulness, sleep and motor activity. Its best-known pharmacological analogues, diazepam and clonazepam, produce a reduction of SB, but they also have severe, undesirable collateral effects, such as sleepiness, dizziness and risk of addiction (15). According to the concepts explained above, SB may be divided into primary or idiopathic SB, that is present without any apparent cause, and secondary SB, due to traumatic injuries, diseases or sometimes pharmacological treatments for other diseases, such as Parkinson's disease (iatrogenic bruxism).…”

Section: Etiopathogenesismentioning

confidence: 99%

Sleep bruxism. Conceptual review and update

Hoz-Aizpurua¹,

Díaz-Alonso²,

LaTouche-Arbizu³

et al. 2011

Med Oral

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Sleep bruxism (SB) is a parafunctional oromotor habit that can sometimes pose a threat to the integrity of the structures of the masticatory system if the magnitude and direction of the forces exerted exceed the system's adaptive capacity. Over the years science has tried to provide a consistent explanation of the etiopathogenesis and physiopathology of SB, although the pathophysiological mechanisms are even now not yet fully understood. There is at present no specific, effective treatment to eliminate the habit of bruxism permanently. There are only palliative therapeutic alternatives steered at preventing the pathological effects of SB on the stomatognathic system and alleviating the negative clinical consequences of the habit. The objective of this article is to review and update the fundamental scientific concepts of SB and to furnish an approach to the main types of therapy used, based on the scientific literature.

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Section: Etiopathogenesismentioning

confidence: 99%

Sleep bruxism. Conceptual review and update

Hoz-Aizpurua¹,

Díaz-Alonso²,

LaTouche-Arbizu³

et al. 2011

Med Oral

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“…8,21 Regarding to the pharmacological treatments, clonidine has a major role, but is associated with secondary adverse effects, demonstrating the necessity for further controlled RCTs with longer follow-up time to verify its real efficacy and safety. 6 Thus, clonazepam becomes a safer alternative and with satisfactory results in the short term. 7,18 It is important to mention here that the clonazepam, like other benzodiazepine drugs, may exacerbate OSAS.…”

Section: Discussionmentioning

confidence: 99%

“…Another drug that also shows good results in the control and management of SB is L-dopa. 11 In relation to amitriptyline, there is no scientific evidence to justify its use in patients with SB, 13,17 same fact occurs with propranolol, 6 tryptophan 3 and bromocriptine. 10 Target of many current studies in the Orofacial Pain investigations, due to its analgesic and antinociceptive properties, botulinum toxin has yet no RCTs analyzing its role in the treatment of SB.…”

Section: Discussionmentioning

confidence: 99%

“…Assessing the effects of clonidine (0.3 mg) and propranolol (120 mg) on the SB, Huynh et al 6 conducted a controlled, double-blind and crossover RCT comparing these drugs to placebo. A sample of 25 patients with a history and diagnosis of SB, was divided randomly into the groups, participating in this study and were monitored by polysomnographic examination.…”

Section: Pharmacological Treatmentsmentioning

confidence: 99%

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Bruxismo do sono: possibilidades terapêuticas baseadas em evidências

Machado¹,

Machado²,

Cunali

et al. 2011

Dental Press J. Orthod.

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Introduction: Sleep bruxism (SB) is defined as a stereotyped and periodic movement disorder, characterized by tooth grinding and/or clenching occurring during sleep, associated with rhythmic masticatory muscle activity. This condition isn't a disease, but when exacerbated may cause an unbalance and changing of orofacial structures. Thus, it is necessary to obtain effective and safe treatments for the control and management of the bruxist patient. The treatment alternatives range from oral devices, pharmacological therapies to cognitive-behavioral techniques. Objective: This study, a systematic literature review having as research bases MEDLINE, Cochrane, EMBASE, Pubmed, Lilacs and BBO, between the years of 1990 and 2008, with focus in randomized and quasi-randomized clinical trials, systematic reviews and meta-analysis, had as objective to analyze and discuss possibilities of treatment for sleep bruxism. Results: According to the literature analysis there is a lot of treatment options for the SB, but many of the therapies have no scientific support. Thus, the choice therapy should be based on scientific evidences and in clinical common sense, for an improvement in quality of life of the bruxist patient. Abstract

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“…Bruksizm etiyolojisine ilikin propanolol ve klonidin ile ilgili çalımalar da mevcuttur. Propanolol, non selektif beta bloker, bruksizmde ve buna bağlı ritmik çiğneme kas aktivitesinde anlamlı bir azalmaya sebep olmazken, klonidin, alfa agonist, santral sinir sistemini aktive ederek bruksizmde anlamlı bir oranda azalma sağlar 67,68 .…”

Section: Etiyolojiunclassified

Bruxism and Current Treatment Approaches

Eren¹,

Arıkan²,

Tamam³

et al. 2016

Arşiv Kaynak Tarama Dergisi

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Among the mastication system disorders bruxism is a parafunctional behavior that comes from psychophysiological origin. Epidemiologic studies have reported great variability of bruxism prevalence. The factors that could cause bruxism is highly controversial. There are different opinions on this issue. The etiologic factors of bruxism include stress, malnutrition, allergic and endocrinologic diseases, central nervous system disorders, genetic factors, medicines, malocclusion, and wrong dental treatment. The aim of treatment of bruxism is to prevent damage that may occur on teeth and in the temporomandibular joint and to eliminate pain. Dental treatment, physical therapy, pharmacological treatment and behavioral and cognitive therapy can be considered for this purpose of treatment. This review summarizes the etiologic factors, epidemiology, diagnosis, and current treatment approaches of patient with bruxism.

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The Effect of 2 Sympatholytic Medications—Propranolol and Clonidine—On Sleep Bruxism: Experimental Randomized Controlled Studies

Cited by 98 publications

References 0 publications

Sleep bruxism. Conceptual review and update

Sleep bruxism. Conceptual review and update

Bruxismo do sono: possibilidades terapêuticas baseadas em evidências

Bruxism and Current Treatment Approaches

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