The Economic Evaluation of Screening for Colorectal Cancer: Case of Iran

Barouni, Mohsen; Ghaderi, Hosien; Shahmoradi, Mohammad Kazem

doi:10.7754/clin.lab.2012.120812

Cited by 8 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The burden of colorectal cancer (CRC) has been broadly acknowledged worldwide and is also a growing health concern in Iran ( Jemal et al, 2010;Pourhoseingholi and Zali, 2012;Barouni et al, 2013;Somi et al, 2014). CRC is the third most prevalent cancer worldwide, but can also be readily diagnosed and prevented at an early stage with the use of appropriate screening methods (Jemal et al, 2010;Siegel et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of colorectal adenoma in an average-risk population aged 40–50 versus 50–60 years

Hemmasi

Sohrabi

Zamani

et al. 2015

European Journal of Cancer Prevention

View full text Add to dashboard Cite

According to current guidelines, screening colonoscopy begins at 50 years for the average-risk population, although there are not enough data on the incidence of precancerous lesions of individuals in the preceding decades. To evaluate the prevalence of colorectal polyps including potentially premalignant lesions in asymptomatic, average-risk individuals aged 40-49 versus 50-59 years, we offered total colonoscopy screening to individuals without any lower gastrointestinal symptoms. The primary end point was the prevalence of colorectal adenoma in two age groups. Of a total of 737 studies, 333 participants were 40-49 years old and 407 participants were 50-59 years old. The overall prevalence of adenomas was 11.2 and 16.4% in the group of 40-49 and 50-59 year olds, respectively. Advanced adenoma was more common in 50-59 year olds (1.2 vs. 2.9%). Malignancy was not reported in these groups. Furthermore, 77.5 and 68.6% of adenomas were observed in the distal colon in the groups of 40-49 year olds and 50-59 year olds, whereas in the proximal colon, 22.2 and 57.1% of adenomas in the groups of 40-49 year olds and 50-59 year olds, respectively, were advanced adenomas. In our study, male sex showed an association with adenoma. However, importantly, there was no significant association between age and colorectal adenoma. Although the prevalence of colorectal adenoma was similar in the two age groups investigated, the rate of advanced adenoma was higher in the group of individuals who were 50-59 years old, suggesting that colorectal cancer screening could be recommended at an age younger than 50 years.

show abstract

Section: Introductionmentioning

confidence: 99%

Prevalence of colorectal adenoma in an average-risk population aged 40–50 versus 50–60 years

Hemmasi

Sohrabi

Zamani

et al. 2015

European Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Studies from the region suggests indirectly that colonoscopy is cost-effective. 15 , 16 Colonoscopy is considered the golden standard against which all other modalities of screening are tested. It must be repeated every 10 years.…”

Section: Discussion and Recommendationsmentioning

confidence: 99%

“…Studies from the region suggests indirectly that FS is cost-effective. 15 , 16 The desired effect of FS clearly outweighs the undesired effects. FS must be repeated every 3 years if performed alone or every 5 years if combined with FIT.…”

Section: Discussion and Recommendationsmentioning

confidence: 99%

See 1 more Smart Citation

National Guidelines for Colorectal Cancer Screening in Saudi Arabia with strength of recommendations and quality of evidence

Al‐Sanea

Almadi

Abduljabbar

et al. 2015

Annals of Saudi Medicine

View full text Add to dashboard Cite

BACKGROUNDColorectal cancer is the most common cancer among Saudi men and the third commonest among Saudi women. Given the predominance of colorectal cancer compared with other cancers in Saudi Arabia, context-specific guidelines are needed for screening.METHODSThe Saudi Centre for Evidence-Based Healthcare assembled a panel of experts from the Saudi Society of Colon and Rectal Surgery, Saudi Gastroenterology Association, the Saudi Oncology Society, the Saudi Chapter of Enterostomal Therapy, the Family Medicine and Department of Public Health at the Saudi Arabian Ministry of Health and a patient advocate. The panel collaborated with a methodological team from McMaster University, Canada to develop national guidelines for colorectal cancer screening. After identifying key questions, the panel conducted a systematic review of all reports on the utility of screening, the cost of screening for colorectal cancer in Saudi Arabia and on the values and preferences of Saudi patients. Meta-analyses, when appropriate, were performed to generate pooled estimates of effect. Using the GRADE approach, the panel used the evidence-to-decision (EtD) framework to assess all domains important in determining the strength and direction of the recommendations (benefits and harms, values and preferences, resource implications, equity, acceptability, and feasibility). Judgments related to the EtD domains were resolved through consensus or voting, if consensus was not reached. The final recommendations were developed during a two-day meeting held in Riyadh, Saudi Arabia in March 2015. Conflicts of interests among the panel members were handled according to the World Health Organization rules.LIMITATIONSThere is lack of national data on the incidence of adenomatous polyps or the age groups in which the incidence surges. There were no national clinical trials assessing the effectiveness of the different modalities of screening for colorectal cancer and their impact on mortality.CONCLUSIONThe panel recommends screening for colorectal cancer in Saudi Arabia in asymptomatic Saudi patients at average risk of colorectal cancer. An infrastructure should be built to achieve that goal.

show abstract

“…The decision making involved in CRC screening in Iran has proven valuable for cost saving with respect to local resources, personal preferences of the patients, or the choice of screening tests, including the highly sensitive stool occult blood test conducted annually (such as stool immunochemistry test) or colonoscopy conducted every 10 years. Colonoscopy is both the most effective and sensitive and the most costly strategy according to latest trials in Iran [25,77,80,81], and many studies recommend it as golden standard tool for early detection of precancerous as well as CRC [77,82]. As well as pathology findings, genetic history and information content on pedigree play a significant role in planning and management of colorectal cancer screening [79].…”

Section: Tumor Markers In Iranian Crcmentioning

confidence: 99%

Colorectal cancer in Iran: Molecular epidemiology and screening strategies.

Dolatkhah

Dastgiri

Bonyadi

et al. 2015

JCO

View full text Add to dashboard Cite

Purpose. The increasing incidence of colorectal cancer (CRC) in the past three decades in Iran has made it a major public health burden. This study aimed to report its epidemiologic features, molecular genetic aspects, survival, heredity, and screening pattern in Iran. Methods. A comprehensive literature review was conducted to identify the relevant published articles. We used medical subject headings, including colorectal cancer, molecular genetics, KRAS and BRAF mutations, screening, survival, epidemiologic study, and Iran. Results. Age standardized incidence rate of Iranian CRCs was 11.6 and 10.5 for men and women, respectively. Overall five-year survival rate was 41%, and the proportion of CRC among the younger age group was higher than that of western countries. Depending on ethnicity, geographical region, dietary, and genetic predisposition, mutation genes were considerably diverse and distinct among CRCs across Iran. The high occurrence of CRC in records of relatives of CRC patients showed that family history of CRC was more common among young CRCs. Conclusion. Appropriate screening strategies for CRC which is amenable to early detection through screening, especially in relatives of CRCs, should be considered as the first step in CRC screening programs.

show abstract

The Economic Evaluation of Screening for Colorectal Cancer: Case of Iran

Cited by 8 publications

References 0 publications

Prevalence of colorectal adenoma in an average-risk population aged 40–50 versus 50–60 years

Prevalence of colorectal adenoma in an average-risk population aged 40–50 versus 50–60 years

National Guidelines for Colorectal Cancer Screening in Saudi Arabia with strength of recommendations and quality of evidence

Colorectal cancer in Iran: Molecular epidemiology and screening strategies.

Contact Info

Product

Resources

About