The Eccrine Sweat Defect in Cystic Fibrosis of the Pancreas (Mucoviscidosis)

Sant'Agnese, Paul A. di; Powell, Gerald F.

doi:10.1111/j.1749-6632.1962.tb30494.x

Cited by 68 publications

(19 citation statements)

References 45 publications

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“…It is known that in patients with cystic fibrosis the NaCl concentration of sweat is higher at a given flow rate than in normal individuals (11)(12)(13). There are several possible explanations for this abnormality.…”

Section: Introductionmentioning

confidence: 97%

Micropuncture studies of the sweat formation in cystic fibrosis patients

Schulz¹

1969

J. Clin. Invest.

144

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A B S T R A C T In order to determine whether the pre- In a second series of experiments the stop-flow pressure which is generated by sweat glands during secretion was measured. Values up to 500 mm Hg were found in both patients and normals. According to van't Hoff's law (AP = RTAC) hydrostatic pressure differences of this magnitude can be generated by the osmotic difference of 27 mOsm/kg of water observed between precursor sweat and plasma in the present experiments. With respect to the mechanism of sweat secretion this finding supports the hypothesis that active solute transport creates an osmotic gradient which causes osmotic water flux.

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Section: Introductionmentioning

confidence: 97%

Micropuncture studies of the sweat formation in cystic fibrosis patients

Schulz¹

1969

J. Clin. Invest.

144

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“…4 mEq/liter/ m2 versus 20.2 + 11.2 mEq/liter/m2) and chloride (46.6 + 21. 6 mEq/liter/m2 versus 18.5 f 11.3 mEq/liter/m2) per unit of surface area than the controls. Serum sodium and chloride concentrations fell in the CF patients but not in the normals.…”

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confidence: 95%

“…~urthermore, CF patients may have decreased serum electrolvte concentrations as the first recognizable manifestation of theirhisease (2, 11). Several investigat&s have discussed possible sequences of events which occur with salt depletion in CF (6,12). But experimental documentation that CF patients actually lose large amounts of salt in their sweat and are thus really at risk for developing heat illness has not been published.…”

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confidence: 99%

Exercise and Heat Stress in Cystic Fibrosis Patients

et al. 1983

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Summary ICystic fibrosis (CF) is characterized by high sweat sodium and chloride concentrations. CF patients have long been assumed to be at risk for heat illness, but there has been no quantitative documentation that CF patients actually have a greater loss of sodium and chloride than normals when under environmental stress. We compared thermoregulatory responses of eight CF patients with five normal controls during 90-min exposures to exercise and heat stress. Both groups reached similar peak rectal temperatures and peak heart rates; they had similar sweat volumes and rates. CF patients showed the normal rise in renin and aldosterone and the normal fall in urine sodium excretion; however, CF patients lost significantly more sodium (48.8 + 23.4 mEq/liter/ m2 versus 20.2 + 11.2 mEq/liter/m2) and chloride (46.6 + 21.6

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“…The parotid gland is not morphologically affected. [1][2][3][4][5] The changes in minor salivary glands have been almost completely ignored, although Bodian 6 found that children who died from cystic fibrosis had pathological changes in these glands. If The skin biopsy punch is placed perpendicular to the surface and rotated to cut through the mucous membrane and the superficial fascia.…”

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confidence: 99%