Biopsy of the Labial Mucous Salivary Glands in Cystic Fibrosis

Meskin, Lawrence H.; Bernard, Betty; Warwick, Warren J.

doi:10.1001/jama.1964.03060270088026

Cited by 12 publications

(2 citation statements)

References 4 publications

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“…Apart from post‐operative complications, the other factor that determines the effectiveness of a labial gland biopsy technique is also whether the technique yields enough glands for diagnosis. Techniques that involve the use of a punch biopsy usually provide little glandular tissue for examination and do not allow for visual identification of sensory fibres, which may lead to increased incidence of post‐operative paraesthesia. Removing an ellipse of mucosa as described in several studies can also lead to damage of unidentified sensory nerves, and also, the epithelium is unnecessarily lost.…”

Section: Discussionmentioning

confidence: 99%

A retrospective analysis of post‐operative outcomes in a series of 108 labial gland biopsies

2014

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Aim: Histopathological assessment of labial salivary glands has long been a core part of the diagnostic criteria for Sjogren's Syndrome. Biopsy of labial salivary glands is technique sensitive and has post-operative complications which can affect the patient's quality of life. Varying techniques for labial gland biopsy and associated complications are described in the literature. This article gives a step-by-step account of an effective technique for labial gland biopsy as described by Daniels in 1984 and provides a retrospective analysis of the post-operative complications in a series of 108 labial gland biopsies. Materials and methods: A retrospective, post-operative telephone survey was carried out to study the post-operative complications of labial gland biopsies performed by a single operator. All consecutive patients (180) who had labial gland biopsies between October 2010 and August 2012 at the Department of Oral Medicine at Guy's Hospital were called, and 108 surveys were successfully completed. The telephone questionnaires aimed to find out medium and long-term complications of labial gland biopsies to include subjective measures of post-operative pain, swelling and paraesthesia. Results: One patient out of 108 patients (0.9%) reported pain that lasted ≥ 6 months, and six patients (5.5%) reported swelling that lasted > 2 weeks. Three patients (2.8%) reported paraesthesia lasting ≥ 6 months with a median bother score of 0. All biopsies provided sufficient glands to allow for histopathological diagnosis. Conclusions: This article describes a safe and effective technique for labial gland biopsy. Despite a low complication rate, informed consent is essential. Clinical relevance Scientific rationale for studyLabial gland biopsy (LGB) is an important component in the diagnosis of Sjogren's Syndrome. It is technique-sensitive and has post-operative complications which can affect the patient's quality of life. Principal findingsThis article provides a retrospective analysis of the post-operative complications in a series of 108 LGB carried out using a technique which has proved to be effective in delivering histopathological diagnosis and has a low level of post-operative complications. bs_bs_banner Oral Surgery ISSN 1752-2471 2 Oral Surgery 8 (2015) 2-9. Practical implicationsThis article gives a step-by-step account of an effective technique for LGB which can be used by clinicians, as well as rates of post-operative complications which are useful when obtaining informed consent from the patient. Post-operative outcomes of labial gland biopsiesAli et al.

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Section: Discussionmentioning

confidence: 99%

A retrospective analysis of post‐operative outcomes in a series of 108 labial gland biopsies

2014

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“…CFTR-related disruption of transmembrane ion transport affects the exocrine glands and results in intestinal, pancreatic, and hepatobiliary complications [ 2 ]. Among the mucus-secreting structures of the alimentary tract affected by CF are the labial salivary glands (LSGs) [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

et al. 2015

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The labial minor salivary glands (LSGs) are easily accessible mucus-secreting structures of the alimentary tract that may provide new information on the basis of gastrointestinal complications of cystic fibrosis (CF). It was shown that they are destructed in the course of cystic fibrosis. We employed wide-field, micrometer resolution in vivo optical coherence tomography to assess the surface density of LSGs in 18 patients with CF and 18 healthy subjects. The median LSGs’ surface densities in CF patients, and in the control group were 4.32 glands/cm2 and 6.58 glands/cm2, respectively (p = 0.006; Mann-Whitney U test). A lower LSG surface density is a previously unrecognized CF-related pathology of the alimentary tract.

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Labial salivary gland biopsy in sjögren's syndrome

Daniels

1984

Arthritis & Rheumatism

496

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Xerostomia is an unsatisfactory diagnostic criterion for the salivary component of Sjögren's syndrome (SS). To determine the diagnostic usefulness of the presence of focal sialadenitis in labial salivary gland (LSG) biopsy specimens, 362 patients suspected of having SS prospectively underwent a unique LSG biopsy procedure. The pattern and severity of LSG inflammation were compared with measurements of parotid flow rate, and the presence or absence of symptomatic xerostomia, major salivary gland enlargement, keratoconjunctivitis sicca (KCS), and other connective tissue diseases (CTD). LSG biopsy focus scores of >1 correlated more closely with the diagnoses of KCS alone and with KCS plus a CTD than did either reduced parotid flow rate or symptoms of xerostomia (P < 0.0005 and P < 0.05, respectively). Focal sialadenitis in an adequate LSG specimen is an objective criterion and a more disease‐specific feature of SS than xerostomia or any other feature of salivary disease. The salivary component of SS should be redefined as the presence of LSG focal sialadenitis.

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Biopsy of the Labial Mucous Salivary Glands in Cystic Fibrosis

Cited by 12 publications

References 4 publications

A retrospective analysis of post‐operative outcomes in a series of 108 labial gland biopsies

A retrospective analysis of post‐operative outcomes in a series of 108 labial gland biopsies

Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

Labial salivary gland biopsy in sjögren's syndrome

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