Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

Nowak, Jan Krzysztof; Grulkowski, Ireneusz; Karnowski, Karol; Wojtkowski, Maciej; Walkowiak, Jarosław

doi:10.1371/journal.pone.0117517

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…Also, when the biopsy is processed for fixation, the epithelium of the mucous membrane separates from the glandular tissue; in normal biopsies the connective tissue layers remain intact (39). Most recently, using the non-invasive technique of optical coherence tomography, a lower density of labial salivary glands has been demonstrated in CF patients than in a group without the disease (41).…”

Section: Cystic Fibrosis (Cf)mentioning

confidence: 99%

Clinical anatomy of the inferior labial gland: a narrative review

Shen¹,

Ono²,

Do³

et al. 2021

Gland Surg

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In this article we review the literature on the inferior labial gland from a clinical and anatomical perspective.Background: Regardless of its importance in clinical practice, there are no medical literature that comprehensively reviewed the inferior labial gland.Method: A database search using PubMed and Google Scholar was conducted. The following keywords were used in the search: "lower labial salivary gland", "lower labial gland", "inferior labial salivary gland", AND "inferior labial gland". Conclusion:The human labial glands are types of minor salivary gland that continuously secrete small amounts of mucous and serous substances to maintain oral health. The inferior labial glands are innervated by the inferior labial branch of the mental nerve, and the inferior labial branch of the facial artery is the main arterial supply to the lower lip. Although they only have an auxiliary role in saliva production compared to the major salivary glands, minor salivary glands provide a certain amount of lubrication in the oral cavity by the continuous outflow of saliva. The inferior labial gland not only promotes moisturization in the oral cavity but also secretes substances with antibacterial effects, which is important for the function of the oral cavity.A recent study showed that the rate of salivary secretion from the inferior labial glands does not change with age, and in some cases the inferior labial glands are used for diagnosing intractable diseases such as Sjogren's syndrome and cystic fibrosis. In addition, since the inferior labial glands themselves can be the site of cyst and/or neoplasia development, we should be careful to distinguish them from other diseases. Elucidation of the anatomy, physiology, and pathology of the inferior labial glands, is important for understanding human health and diseases.

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Section: Cystic Fibrosis (Cf)mentioning

confidence: 99%

Clinical anatomy of the inferior labial gland: a narrative review

Shen¹,

Ono²,

Do³

et al. 2021

Gland Surg

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“…Its participants were age‐matched to a group of middle‐aged patients with Sjögren's syndrome . The other concerned the diagnostic potential of LSGs’ OCT in cystic fibrosis and explored its mucosal pathology . The control group for the CF study was age‐matched to the patient population, which was young.…”

Section: Introductionmentioning

confidence: 99%

“…25 The other concerned the diagnostic potential of LSGs' OCT in cystic fibrosis and explored its mucosal pathology. 26 The control group for the CF study was age-matched to the patient population, which was young. This research concerns the two groups of healthy subjects, which differed both in age and in body mass index (BMI).…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography of the Labial Salivary Glands Reveals Age‐Related Differences in Women

Nowak

Grulkowski

Karnowski

et al. 2015

Clinical Translational Sci

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The labial minor salivary glands (LSGs) play a role in medical research and practice due to their superficial location and involvement in both systemic and localized diseases. Swept-source optical coherence tomography (OCT) is a noninvasive modality that enables in vivo, micrometer resolution, wide-field three-dimensional imaging in seconds. A purpose-built swept-source OCT instrument was employed to acquire three-dimensional datasets covering the area of 2.43 cm 2 of the mucosa of the lower lip to the depth of 3.4 mm in young (n = 14; mean age ± SD: 27 ± 3 years; body mass index [BMI] 20.4 ± 2.3 kg/m 2 ) and middle-aged women (n = 11; 54 ± 6 years; 25.5 ± 3.2 kg/m 2 ). Glandular tissue reflectivity mode (range 0-255; 86 ± 17 vs. 68 ± 12, p = 0.005), average single LSG area in tissue sample (5.26 ± 2.62 mm 2 vs. 2.87 ± 1.26 mm 2 , p = 0.011), and LSG surface filling factor (0.23 ± 0.13 vs. 0.11 ± 0.10, p = 0.027) had higher values in younger than in middle-aged women. A correlation between BMI and glandular tissue reflectivity mode (Spearman's ρ = -0.60) was found (p = 0.002). The results highlight the potential value of LSGs' OCT morphometry in research regarding ageing.

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Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

Cited by 2 publications

References 28 publications

Clinical anatomy of the inferior labial gland: a narrative review

Clinical anatomy of the inferior labial gland: a narrative review

Optical Coherence Tomography of the Labial Salivary Glands Reveals Age‐Related Differences in Women

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