The Early Natural History of SARS-CoV-2 Infection

Cohen, Pieter A.; Hall, L.; John, J.; Rapoport, Alison B

doi:10.1016/j.mayocp.2020.04.010

Cited by 111 publications

(58 citation statements)

References 6 publications

(5 reference statements)

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“…Early recognition of patients with worsening respiratory function while on conventional oxygen therapies is important to ensure the timely and safe escalation of respiratory support [6]. Hypoxia symptoms as an indicator of hypoxia injury were recognized to be one of the most important hallmarks of COVID-19 coronavirus infection and can easily be identified by patients themselves [23]. The association between oxygen therapy initiation after the onset of hypoxia symptoms and the outcome of the disease was analyzed in our study.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in China

Lü

Chen

et al. 2021

PLoS Negl Trop Dis

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Background Until now, no antiviral treatment has been proven to be effective for the coronavirus disease 2019 (COVID-19). The timing of oxygen therapy was considered to have a great influence on the symptomatic relief of hypoxemia and seeking medical intervention, especially in situations with insufficient medical resources, but the evidence on the timing of oxygen therapy is limited. Methods and findings Medical charts review was carried out to collect the data of hospitalized patients with COVID-19 infection confirmed in Tongji hospital, Wuhan from 30th December 2019 to 8th March 2020. In this study, the appropriate timing of oxygen therapy and risk factors associated with severe and fatal illness were identified and the effectiveness of antivirus on disease progression was assessed. Among 1362 patients, the prevalence of hypoxia symptoms was significantly higher in those patients with severe and fatal illness than in those with less severe disease. The onset of hypoxia symptoms was most common in the second to third week after symptom onset, and patients with critical and fatal illness experienced these symptoms earlier than those with mild and severe illness. In multivariable analyses, the risk of death increased significantly when oxygen therapy was started more than 2 days after hypoxia symptoms onset among critical patients (OR, 1.92; 95%CI, 1.20 to 3.10). Compared to the critically ill patients without IFN-a, the patients who were treated with IFN-a had a lower mortality (OR, 0.60; 95%CI, 0.39 to 0.91). Conclusions Early initiation of oxygen therapy was associated with lower mortality among critical patients. This study highlighted the importance of early oxygen therapy after the onset of hypoxia symptoms. Our results also lend support to potentially beneficial effects of IFNα on critical illness.

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Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in China

Lü

Chen

et al. 2021

PLoS Negl Trop Dis

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“…The main topics which are covered by the current published literature are: (i) telemedicine and remote care [ 7 ], (ii) monitoring and self-assessment of possible symptoms [ 8 ], (iii) medical education [ 9 ], (iv) training to deal with COVID-19 in the practice [ 10 ], (v) the current situation in general practice [ 11 ], (vi) how general practice is expected to change during and after the COVID-19 pandemic [ 12 ] and (vii) the burden COVID-19 brings to health care providers [ 13 ], but general practitioners were not well represented in most of the surveys assessing this [ 14 ]. Also, papers describing COVID-19 cases’ characteristics from outpatient settings are scarce [ 15 ].…”

Section: Research Agendamentioning

confidence: 99%

Academic general practice/family medicine in times of COVID-19 – Perspective of WONCA Europe

Windak

Frese

Hummers

et al. 2020

European Journal of General Practice

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“…Also, COVID-19 pneumonia can co-exist with other common cardiopulmonary disorders. Based on the clinical observation, Cohen et al mentioned certain soft (but not pathognomonic) pointers towards the diagnosis of COVID-19: i) shortness of breath between the 4 th and 8 th day of symptom onset, ii) breathlessness without productive cough, iii) sudden drop in oxygen saturation with minimal exertion [3]. Atypical symptoms like diarrhea or sudden loss of olfactory sensation are also been reported with COVID-19 [4].…”

Section: Case #3mentioning

confidence: 99%

COVID-19 and clinical mimics. Correct diagnosis is the key to appropriate therapy

Sahu

Mishra

Martin

et al. 2020

Monaldi Arch Chest Dis

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As of 29 April 2020, across the globe, there are 3,216,353 confirmed Coronavirus disease 2019 (COVID-19 disease) with 227,894 deaths. The health care infrastructure of most of the countries is overwhelmed due to the gigantic upsurge of the new cases within a short time period. Most of the beds in the regular wards and critical care units are currently occupied by either people under investigation (PUI) or COVID-19 confirmed cases. We hereby discuss the challenges faced while approaching any case of shortness of breath, or other common upper respiratory symptoms during the current COVID-19 pandemic era.

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The Early Natural History of SARS-CoV-2 Infection

Cited by 111 publications

References 6 publications

Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in China

Effect of early oxygen therapy and antiviral treatment on disease progression in patients with COVID-19: A retrospective study of medical charts in China

Academic general practice/family medicine in times of COVID-19 – Perspective of WONCA Europe

COVID-19 and clinical mimics. Correct diagnosis is the key to appropriate therapy

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