The Early Clinical Manifestations of Lyme Disease

Steere, Allen C.; Bartenhagen, Nicholas H.; Craft, Joseph; Hutchinson, Gordon J.; Newman, James H.; Rahn, Daniel W.; Sigal, Leonard H.; Spieler, Phyllis N.; Stenn, Kurt S.; Malawista, Stephen E.

doi:10.7326/0003-4819-99-1-76

Cited by 602 publications

(259 citation statements)

References 23 publications

Supporting

Mentioning

223

Contrasting

Unclassified

Order By: Relevance

“…EM is usually asymptomatic, but sometimes there is tingling, burning, pain, or mild pruritus. EM may be accompanied by constitutional signs and symptoms such as malaise, headache, fever, myalgia, or regional lymphadenopathy (21).…”

Section: Cutaneous Manifestations Of Lyme Diseasementioning

confidence: 99%

Ticks, Borrelia Burgdorferi and Lyme Disease

Bağcı¹,

Ruzicka²

2016

tdd

View full text Add to dashboard Cite

Lyme disease, which is caused by spirochete Borrelia burgdorferi sensu lato, is a ticktransmitted, multisystem infectious disease. It occurs in stages, with different clinical manifestations at each stage. Erythema migrans is the most frequent manifestation which occurs at the site of the tick bite. Borrelial lymphocytoma and acrodermatitis chronica atrophicans are late-stage cutaneous manifestations. Extracutaneous signs of infection most often involve the musculoskeletal, cardiovascular, and nervous systems. Serologic assays remain the mainstay of diagnosis. All stages of the disease are curable with appropriate antibiotic therapy. Keywords: Lyme disease, Borrelia burgdorferi, erythema migrans, acrodermatitis chronica atrophicans, ticks, Ixodes Işın Sinem Bağcı, Thomas Ruzicka* Ticks, Borrelia Burgdorferi and Lyme DiseaseKeneler, Borrelia Burgdorferi ve Lyme Hastalığı Öz AbstractLyme hastalığı Borrelia burgdorferi sensu lato grubu spiroketlerin sebep olduğu multisistemik bir enfeksiyon hastalığıdır. Her hastalık evresi değişik klinik bulgularla kendini gösterir. En sık klinik bulgusu kene ısırık yerinde gelişen eritema migranstır. Borrelial lenfositoma ve akrodermatitis kronika atrofikans geç dönemde gelişen deri bulgularıdır. Deri bulguları dışında kas-iskelet, kardiyovasküler ve sinir sistemi tutulumu da görülebilir. Tanı serolojik testler ile konulur. Hastalığın her evresi uygun antibiyotiklerle tedavi edilebilir.

show abstract

Section: Cutaneous Manifestations Of Lyme Diseasementioning

confidence: 99%

Ticks, Borrelia Burgdorferi and Lyme Disease

Bağcı¹,

Ruzicka²

2016

tdd

View full text Add to dashboard Cite

show abstract

“…Borreliae can be divided into several genospecies, of which B. burgdorferi sensu stricto, B. afzelii, and B. garinii have been identified as important human pathogens. The first dermatologic symptom of the infection, erythema migrans, is histologically characterized by a small number of neutrophils, which is an untypical finding in bacterial infections (1). In many cases, the infection is limited to the skin and subsides even without treatment.…”

mentioning

confidence: 99%

TLR2 Utilization ofBorreliaDoes Not Induce p38- and IFN-β Autocrine Loop-Dependent Expression of CD38, Resulting in Poor Migration and Weak IL-12 Secretion of Dendritic Cells

Hartiala

Hytönen²,

Yrjänäinen³

et al. 2010

The Journal of Immunology

View full text Add to dashboard Cite

Lyme borreliosis is a tick-borne bacterial infection that in many cases is limited to the skin. However, in some patients the bacterium evades the immune response and disseminates into various organs. Dendritic cells (DCs) are among the first cells to meet invading pathogens in the skin. We have previously shown that CD38, an ectoenzyme involved in the migration of DCs and generally upregulated by microbial stimuli, is not upregulated in Borrelia garinii-stimulated DCs. In this paper, we characterize the cellular events that lead to the absence of CD38 on the DC surface after B. garinii stimulation and investigate the consequences of absent CD38 expression for the migration of DCs in vitro and in vivo. The data show that 1) effective signaling via p38 MAPK (and STAT1 and NF-κB) is needed for CD38 expression and 2) TLR2 stimulation, as opposed to TLR4 stimulation, does not induce IFN-β autocrine loop-dependent expression of CD38 and secretion of IL-12. Further, we show that 3) B. garinii-stimulated DCs do not migrate effectively toward CCL19 and CCL21 and 4) after B. garinii infection of mice, the number of DCs migrating from the infection site to draining lymph nodes is only half that induced by Escherichia coli infection. Our results provide evidence for the first time that different TLR use results in different CD38 expression, which correlates with the migratory potential of DCs.

show abstract

“…В ряде случаев встречается латентная инфекция. Для ИКБ характерна и хроническая ин-фекция, которая может развиваться как после клинической стадии острого и подо-строго боррелиоза, так и после периода латентной инфекции [5,6].…”

unclassified

Clinical case of ixodes tick-borne borreliosis with development a-v blockade and implantation of the pacemaker

Лыгина

Мирошкин

2017

Rossiyskiy mediko-biologicheskiy vestnik

View full text Add to dashboard Cite

Borreliosis is an infectious transmissible natural-focal disease caused by borrelia of borrelia burgdorferi sensu lato group and transmitted by ixodic ticks. In the article a clinical case of chronic ixodic tick-borne borreliosis is described with the primary damage to the heart, joints and with polyneuropathy of extremities. The described clinical case is interesting on the one hand by demonstration of peculiarities of the heart damage associated with ixodic tick-borne borreliosis which finally lead to transient III degree A-V block with episodes of asystole up to 5.5 s and to implantation of continuous pacemaker. On the other hand, surprising in XXI century is the fact that despite a wide availability of high-tech methods of diagnostics and treatment in any field of medicine, the ixodic tick-borne borreliosis was identified only in 6 years after the moment of manifestations of clinical symptoms.

show abstract

The Early Clinical Manifestations of Lyme Disease

Cited by 602 publications

References 23 publications

Ticks, Borrelia Burgdorferi and Lyme Disease

Ticks, Borrelia Burgdorferi and Lyme Disease

TLR2 Utilization ofBorreliaDoes Not Induce p38- and IFN-β Autocrine Loop-Dependent Expression of CD38, Resulting in Poor Migration and Weak IL-12 Secretion of Dendritic Cells

Clinical case of ixodes tick-borne borreliosis with development a-v blockade and implantation of the pacemaker

Contact Info

Product

Resources

About