The Dynamics of Glomerular Ultrafiltration in the Rat

Brenner, Barry M.; Troy, Julia L.; Daugharty, Terrance M.

doi:10.1172/jci106667

Cited by 280 publications

(126 citation statements)

References 15 publications

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“…It is well documented that a close relationship exists between RPF and GFR, and that RPF is one of the major determinants of GFR, as reviewed by Brenner and Humes [12]. Our study also revealed a close relationship between these two variables (Fig.…”

Section: Discussionsupporting

confidence: 85%

The effect of intravenous insulin infusion on kidney function in insulin-dependent diabetes mellitus

1981

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Summary. Glomerular filtration rate, renal plasma flow, urinary excretion of fl-2-microglobulin and albumin, heart rate and blood pressure were studied in eight young male insulin-dependent diabetics. Measurements were performed before and during insulin infusion at 2 mU/kg/min: No patient had discernible insulin antibodies. Two studies were performed at random in each patient. In series A blood glucose concentration was allowed to decline, while in series B it was maintained at a constant level. Ten 20 min clearance periods were performed, four before and six during insulin infusion. Results are given as mean+SEM of .values from the first four (control) and last four (test) clearance periods. Blood glucose declined in series A experiments from 10.8_+0.8 mmol/1 in the control period to 5.8+0.5 mmol/1 during the test period, but remained constant during experiment B (9.8+ 1.1 and 9.5_+ 1.1 mmol/1). Plasma insulin levels were comparable in the two series. GIomerular filtration rate fell from 141+7 ml/ min • 1.73 m 2 to 132_+7 ml/min X 1.73 m 2 (p < 0.01) in series A but did not change significantly during series B. Similarily renal plasma flow declined with declining glucose but remained constant when glucose was maintained at a constant level. In series A the magnitude of decrease in renal plasma flow was correlated with the magnitude of decrease in glomerular filtration rate (r = 0.95, p < 0.001). fl-2-microglobulin excretion decreased significantly (p < 0.05) in both series (A: 89+17 to 60_+13 ng/min, B: 117_+46 to 62_+17ng/min). Albumin excretion increased in five out of six patients with normal control values (not significant) in series A and in four out of six in series B. No significant changes in heart rate or blood pressure were observed. Thus insulin infusion reduced renal plasma flow and glomerular filtration rate, but this effect could be completely abolished by keeping blood glucose constant. This suggests that it is not the lack of insulin but the associated hyperglycaemia which contributes to the elevated renal plasma flow and glomerular filtration rate in insulin-dependent diabetics.

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Section: Discussionsupporting

confidence: 85%

The effect of intravenous insulin infusion on kidney function in insulin-dependent diabetes mellitus

1981

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“…The mean sngfr was 52.7±2.9 nl/min/g kidney wt in the control plasma-expanded condition and fell to 24.4±1.9 nl/min g kidney wt (n = 7) (P < 0.001) after infusion of AGBM Ab ( Fig. 1 and Table II).…”

Section: Introductionmentioning

confidence: 89%

“…A value for the glomerular permeability coefficient (LpA) is also generated by this method (sngfr = LpA -EFP). At filtration pressure equilibrium (WrE -AP) as has been demonstrated for the hydropenic MunichWistar rat (11,17,24), a specific numerical value for LpA and EFP cannot be defined, but rather only a minimal and maximal possible value, respectively. However, at higher rates of rpf, produced by isoncotic plasma volume expansion in this study, the efferent EFP becomes significantly positive, or AP greatly exceeds 7rE.…”

Section: Introductionmentioning

confidence: 99%

Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Blantz¹,

Wilson²

1976

J. Clin. Invest.

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A B S T R A C T Nephron filtration rate (sngfr) and the factors controlling filtration were examined before and within 60 min of the intravenous infusion of 225-450 Ag of antiglomerular basement membrane antibody (AGBM Ab) (> 50% antigenic saturation) in plasma-expanded (2.5% body wt) Munich-Wistar rats. Pressures in glonmerular capillaries (PG) and Bowman's space (Pt) were measured with a servo-nulling device, systemic (l7rA) and efferent arteriolar oncotic pressures (irE) were measured by microprotein methods, and nephron plasma flow (rpf) and sngfr were measured by micropuncture techniques in both control and post-AGBM Ab conditions in each rat. The sngfr fell from 52.7±2.9 to 24.1±+1.9 nl/min per g kidney wt (n = 7, P <0.001).Both afferent and efferent arteriolar resistances increased and rpf fell from 221±25 to 90±9 nl/min per g kidney wt (P < 0.001) but the hydrostatic pressure gradient across the glomerular membrane (AP = PG -Pt) increased from 37±1 to 50±2 mm Hg (P < 0.001). The increase in AP and a numerical decrease in TA both acted to maintain sngfr after AGBM Ab and effectively nullified the influence of decreased rpf upon sngfr. The nmean effective filtration pressure (EFP = AP -i) increased from 14±2 to 30±3 mm Hg (P < 0.001) while sngfr decreased. The major and critical reason for this reduction in sngfr was a decrease in the glomerular permeability coefficient from 0.077+0.017 to 0.014+0.001 nl/s per g kidney wt per mm Hg (P <0

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“…Besides its effect on efferent arteriolar resistance, Ang II has a marked influence on glomerular mesangial tone. Ang II promotes mesangial cell contraction and thus a decrease in the glomerular capillary ultrafiltration coefficient (Kf) (30,31). The Kf-lowering effect of Ang II is attenuated by the stimulatory effect of Ang II on the production of vasodilatory prostaglandins (32).…”

Section: Renal Actions Of Angiotensin IImentioning

confidence: 99%

Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance.

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The Dynamics of Glomerular Ultrafiltration in the Rat

Cited by 280 publications

References 15 publications

The effect of intravenous insulin infusion on kidney function in insulin-dependent diabetes mellitus

The effect of intravenous insulin infusion on kidney function in insulin-dependent diabetes mellitus

Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Renal actions of angiotensin-(1-7)

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