The dynamics and regulation of chromatin remodeling during spermiogenesis

Hao, Shuang-Li; Ni, Fei-Da; Yang, Wan-Xi

doi:10.1016/j.gene.2019.05.027

Cited by 68 publications

(51 citation statements)

References 138 publications

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“…Here, SIRT1 was found in different yak testicular cells, including spermatogonia, spermatocyte, round spermatids, Sertoli cell and Leydig cell (Figure 1c), which implied the potential role of SIRT1 in these cells. During the transition from spermatocyte into spermatozoa, the nucleus of germ cell undergoes a unique process in which the nucleosome transforms from a histone‐based structure into a protamine‐based configuration, which needs the hyperacetylation of histones (Bao & Bedford, 2016; Hao, Ni, & Yang, 2019). As a result, it is speculated that the deficiency of SIRT1 in yak elongated spermatids (Figure 1c) is beneficial for histone hyperacetylation and the structure transform of the nucleosome.…”

Section: Discussionmentioning

confidence: 99%

Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF‐1

Yin

Qin

Wang

et al. 2020

Reprod Domestic Animals

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Cattleyak, which are interspecific hybrids between cattle and yak, display much higher growth performances than yak. However, F1 male cattleyak are infertile due to defective testicular development. Sirtuin 1 (SIRT1) is a histone deacetylase that is essential for various biological processes, while the roles of testicular SIRT1 in yak and cattleyak are still poorly understood. Here, we found that SIRT1 was localized in various kinds of yak testicular cells except elongated spermatids while it was deficient in cattleyak testis. Further studies indicated that cattleyak testis exhibited decreased histone acetylation levels on H3 and H4. One of SIRT1 co‐factors, steroidogenic factor‐1 (SF‐1), was lost in cattleyak testis at protein level. Expressions of several SF‐1 target genes responsible for Sertoli cell development and steroidogenesis, including STAR, CYP11A1, CYP26B1, FDX1 and HSD3B, decreased significantly in cattleyak testis. In addition, SIRT1‐mediated P53 acetylation was not responsible for the cell apoptosis in cattleyak testis. Taken together, our results suggested the deficiency of SIRT1 in yak testis caused inactivation of SF‐1 and the impairment of testicular development. This research provides theoretical bases for understanding the mechanism of cattleyak sterility and gives new insights in revealing the roles of SIRT1 in regulating yak testicular development.

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Section: Discussionmentioning

confidence: 99%

Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF‐1

Yin

Qin

Wang

et al. 2020

Reprod Domestic Animals

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“…During spermatid elongation, the marginal ring of the acroplaxome and the perinuclear ring of the manchette reduce their diameter as they gradually descend along the nucleus toward the spermatid tail [53] in a zipper-like movement that facilitates nuclear condensation and shaping [54]. (5) The last mechanism proposed to influence nuclear shaping is chromatin condensation via replacement of histones by transition proteins and then protamines [55]. The acroplaxome, which covers more than one-third of the head, modulates the external forces and anchors the acrosome to the nucleus.…”

Section: Flagellar Formationmentioning

confidence: 99%

Sperm Differentiation: The Role of Trafficking of Proteins

Teves

Roldán

Krapf

et al. 2020

IJMS

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Sperm differentiation encompasses a complex sequence of morphological changes that takes place in the seminiferous epithelium. In this process, haploid round spermatids undergo substantial structural and functional alterations, resulting in highly polarized sperm. Hallmark changes during the differentiation process include the formation of new organelles, chromatin condensation and nuclear shaping, elimination of residual cytoplasm, and assembly of the sperm flagella. To achieve these transformations, spermatids have unique mechanisms for protein trafficking that operate in a coordinated fashion. Microtubules and filaments of actin are the main tracks used to facilitate the transport mechanisms, assisted by motor and non-motor proteins, for delivery of vesicular and non-vesicular cargos to specific sites. This review integrates recent findings regarding the role of protein trafficking in sperm differentiation. Although a complete characterization of the interactome of proteins involved in these temporal and spatial processes is not yet known, we propose a model based on the current literature as a framework for future investigations.

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“…The main target of ROS is guanine due to its lower redox potential, with the major by-product of the DNA oxidation being 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-OHdG); this oxidative DNA damage can be lethal for cells. While spermatogonia and spermatocytes have extensive DNA repair machinery, condensing spermatids and spermatozoa lose their DNA repair capacity [39][40][41].…”

Section: Introductionmentioning

confidence: 99%

The Exacerbation of Aging and Oxidative Stress in the Epididymis of Sod1 Null Mice

2020

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There is growing evidence that the quality of spermatozoa decreases with age and that children of older fathers have a higher incidence of birth defects and genetic mutations. The free radical theory of aging proposes that changes with aging are due to the accumulation of damage induced by exposure to excess reactive oxygen species. We showed previously that absence of the superoxide dismutase 1 (Sod1) antioxidant gene results in impaired mechanisms of repairing DNA damage in the testis in young Sod1 −/− mice. In this study, we examined the effects of aging and the Sod −/− mutation on mice epididymal histology and the expression of markers of oxidative damage. We found that both oxidative nucleic acid damage (via 8-hydroxyguanosine) and lipid peroxidation (via 4-hydroxynonenal) increased with age and in Sod1 −/− mice. These findings indicate that lack of SOD1 results in an exacerbation of the oxidative damage accumulation-related aging phenotype.

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The dynamics and regulation of chromatin remodeling during spermiogenesis

Cited by 68 publications

References 138 publications

Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF‐1

Absence of Sirtuin 1 impairs the testicular development in cattleyak by inactivating SF‐1

Sperm Differentiation: The Role of Trafficking of Proteins

The Exacerbation of Aging and Oxidative Stress in the Epididymis of Sod1 Null Mice

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