The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer

Huang, Jiapeng; Yu, Shengwei; Ding, Lei; Ma, Lingyuan; Chen, Hongjian; Zhou, Hui; Zou, Yayan; Yu, Min; Lin, Jie; Cui, Qinghua

doi:10.3390/biomedicines9111590

Cited by 17 publications

(11 citation statements)

References 160 publications

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“…Aberrantly expressed miRNAs are implicated in several oncogenic processes, including cell proliferation, differentiation, migration, and apoptosis [ 17 , 18 ]. Recently, an increasing number of studies have focused on the differential expression of certain miRNAs in various solid tumors, such as breast [ 19 ], lung [ 20 ], prostate [ 21 ], colon [ 22 ], ovarian [ 23 ], and HNC [ 9 ]. Deregulated miRNA expression levels can be tissue-specific and miRNAs can be characterized as oncogenic (OncomiRs), or tumor suppressor miRNAs, depending on the genes that they regulate and their mode of action.…”

Section: Introductionmentioning

confidence: 99%

Promising Biomarkers in Head and Neck Cancer: The Most Clinically Important miRNAs

Thomaidou

Batsaki

Adamaki

et al. 2022

IJMS

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Head and neck cancers (HNCs) comprise a heterogeneous group of tumors that extend from the oral cavity to the upper gastrointestinal tract. The principal etiologic factors for oral tumors include tobacco smoking and alcohol consumption, while human papillomavirus (HPV) infections have been accused of a high incidence of pharyngeal tumors. Accordingly, HPV detection has been extensively used to categorize carcinomas of the head and neck. The diverse nature of HNC highlights the necessity for novel, sensitive, and precise biomarkers for the prompt diagnosis of the disease, its successful monitoring, and the timely prognosis of patient clinical outcomes. In this context, the identification of certain microRNAs (miRNAs) and/or the detection of alterations in their expression patterns, in a variety of somatic fluids and tissues, could serve as valuable biomarkers for precision oncology. In the present review, we summarize some of the most frequently studied miRNAs (including miR-21, -375, -99, -34a, -200, -31, -125a/b, -196a/b, -9, -181a, -155, -146a, -23a, -16, -29, and let-7), their role as biomarkers, and their implication in HNC pathogenesis. Moreover, we designate the potential of given miRNAs and miRNA signatures as novel diagnostic and prognostic tools for successful patient stratification. Finally, we discuss the currently ongoing clinical trials that aim to identify the diagnostic, prognostic, or therapeutic utility of miRNAs in HNC.

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Section: Introductionmentioning

confidence: 99%

Promising Biomarkers in Head and Neck Cancer: The Most Clinically Important miRNAs

Thomaidou

Batsaki

Adamaki

et al. 2022

IJMS

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“…It is well known that circRNAs can interact with miRNAs to regulate diverse physiological and pathological processes including cancer 26 . Here, we found that circ‐MALAT1 has a binding site for miR‐506‐3p, and this interaction was validated by the dual‐luciferase reporter assay.…”

Section: Discussionmentioning

confidence: 59%

Circ‐MALAT1 accelerates cell proliferation and epithelial mesenchymal transformation of colorectal cancer through regulating miR‐506‐3p/KAT6B axis

Yang,

Gong,

Qiu

2023

The Kaohsiung J of Med Scie

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Colorectal cancer (CRC) is a prevalent malignant tumor of the digestive tract. Circular RNAs may play important roles in the progression of CRC. In this study, we investigated the roles and mechanisms of action of circ‐MALAT1 in CRC. Gene expression and protein abundance were determined using qRT‐PCR and western blot, respectively. Cell proliferation and migration were assessed by MTT, clone formation, and wound‐healing assays. The interactions among the long non‐coding RNA metastasis‐associated lung adenocarcinoma transcript 1 (circ‐MALAT1), miR‐506‐3p, and lysine acetyltransferase 6B (KAT6B) were predicted using the StarBase software and confirmed by the luciferase activity assay. Circ‐MALAT1 and KAT6B were upregulated, while miR‐506‐3p was downregulated in CRC cells. We validated that knocking down of circ‐MALAT1 suppressed proliferation, migration, and epithelial–mesenchymal transition (EMT) of CRC cells, and these effects were abolished by miR‐506‐3p downregulation or KAT6B sufficiency. Our study suggests that circ‐MALAT1 could sponge miR‐506‐3p to regulate the expression of KAT6B. Moreover, KAT6B sufficiency could neutralize miR‐506‐3p‐dependent growth arrest, migration, and EMT. Circ‐MALAT1 promotes cell proliferation, migration, and EMT of CRC cells via the miR‐506‐3p/KAT6B axis, thereby acting as a novel potential therapeutic target for the treatment of colorectal cancer.

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“…More studies have shown that abnormally expressed circRNAs are involved in the occurrence and development of CRC by acting as competing endogenous RNAs ( 72 ). CircCCDC66 is a recently discovered novel circRNA that is up-regulated in colon cancer tissues and promotes colon cancer progression.…”

Section: Circccdc66 and Colorectal Cancermentioning

confidence: 99%

CircCCDC66: Emerging roles and potential clinical values in malignant tumors

et al. 2023

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Circular RNAs (circRNAs) are endogenous non-coding RNAs (ncRNAs) with a closed-loop structure. In recent years, circRNAs have become the focus of much research into RNA. CircCCDC66 has been identified as a novel oncogenic circRNA and is up-regulated in a variety of malignant tumors including thyroid cancer, non-small cell carcinoma, gastric cancer, colorectal cancer, renal cancer, cervical cancer, glioma, and osteosarcoma. It mediates cancer progression by regulating epigenetic modifications, variable splicing, transcription, and protein translation. The oncogenicity of circCCDC66 suppresses or promotes the expression of related genes mainly through direct or indirect pathways. This finding suggests that circCCDC66 is a biomarker for cancer diagnosis, prognosis assessment and treatment. However, there is no review on the relationship between circCCDC66 and cancers. Thus, the expression, biological functions, and regulatory mechanisms of circCCDC66 in malignant tumor and non-tumor diseases are summarized. The clinical value and prognostic significance of circCCDC66 are also evaluated, which can provide insights helpful to those exploring new strategies for the early diagnosis and targeted treatment of malignancies.

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The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer

Cited by 17 publications

References 160 publications

Promising Biomarkers in Head and Neck Cancer: The Most Clinically Important miRNAs

Promising Biomarkers in Head and Neck Cancer: The Most Clinically Important miRNAs

Circ‐MALAT1 accelerates cell proliferation and epithelial mesenchymal transformation of colorectal cancer through regulating miR‐506‐3p/KAT6B axis

CircCCDC66: Emerging roles and potential clinical values in malignant tumors

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