The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors

Abstract

Bone tumors, including primary bone tumors, invasive bone tumors, metastatic bone tumors, and others, are one of the most clinical difficulties in orthopedics. Once these tumors have grown and developed in the bone system, they will interact with osteocytes and other environmental cells in the bone system’s microenvironment, leading to the eventual damage of the bone’s physical structure. Surgical procedures for bone tumors may result in permanent defects. The dual-efficacy of tissue regeneration and tumor treatment has made biomaterial scaffolds frequently used in treating bone tumors. 3D printing technology, also known as additive manufacturing or rapid printing prototype, is the transformation of 3D computer models into physical models through deposition, curing, and material fusion of successive layers. Adjustable shape, porosity/pore size, and other mechanical properties are an advantage of 3D-printed objects, unlike natural and synthetic material with fixed qualities. Researchers have demonstrated the significant role of diverse 3D-printed biological scaffolds in the treatment for bone tumors and the regeneration of bone tissue, and that they enhanced various performance of the products. Based on the characteristics of bone tumors, this review synthesized the findings of current researchers on the application of various 3D-printed biological scaffolds including bioceramic scaffold, metal alloy scaffold and nano-scaffold, in bone tumors and discussed the advantages, disadvantages, and future application prospects of various types of 3D-printed biological scaffolds. Finally, the future development trend of 3D-printed biological scaffolds in bone tumor is summarized, providing a theoretical foundation and a larger outlook for the use of biological scaffolds in the treatment of patients with bone tumors.

Nano-Scaffold Containing a Functional Motif of Stromal Cell-Derived Factor 1 Enhances Neural Stem Cell Behavior and Promotes Synaptogenesis in a Traumatic Brain Injury Model

“…Firstly, they should be biocompatible and biodegradable, meaning they do not cause adverse reactions and can be safely absorbed by the body over time [42,43]. To ensure that the novel Nano-SDF was safe for NSCs, we evaluated its cytotoxicity, comparing survival rates and apoptosis with those induced by the R-GSIK.…”

Synthesis of a 3D Porous Multicomponent Bioceramic Scaffold

“…These identified issues pose obstacles for the optimal development of bioceramic scaffolds. Consequently, there is a growing demand for multicomponent bioceramics as a strategy to overcome these challenges and enhance the overall performance of scaffolds in the context of tissue engineering and cancer treatment (Liu et al, 2023;Ma et al, 2023). For this purpose, multicomponent bioceramics have been developed.…”