The Drosophila Female Sterile Mutation twin peaks Is a Novel Allele of tramtrack and Reveals a Requirement for Ttk69 in Epithelial Morphogenesis

French, Rachael L.; Cosand, K. Amber; Berg, Celeste A.

doi:10.1006/dbio.2002.0856

Cited by 41 publications

(70 citation statements)

References 62 publications

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“…Subsequent tube elongation, by contrast, appears to be driven basally; specifically, the basal sides of the appendage-forming cells crawl forward on the surrounding extracellular matrix, pulling the apical surface into an elongated shape (Boyle and Berg, 2009;French et al, 2003;Peters et al, 2013). This raises the question: which, if any, of these morphogenetic mechanisms are conserved in other species?…”

Section: Introductionmentioning

confidence: 99%

Diversity of epithelial morphogenesis during eggshell formation in drosophilids

et al. 2015

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The eggshells of drosophilid species provide a powerful model for studying the origins of morphological diversity. The dorsal appendages, or respiratory filaments, of these eggshells display a remarkable interspecies variation in number and shape, and the epithelial patterning underlying the formation of these structures is an area of active research. To extend the analysis of dorsal appendage formation to include morphogenesis, we developed an improved 3D image reconstruction approach. This approach revealed considerable interspecies variation in the cell shape changes and neighbor exchanges underlying appendage formation. Specifically, although the appendage floor in Drosophila melanogaster is formed through spatially ordered neighbor exchanges, the same structure in Scaptodrosophila pattersoni is formed through extreme changes in cell shape, whereas Drosophila funebris appears to display a combination of both cellular mechanisms. Furthermore, localization patterns of Par3/Bazooka suggest a self-organized, cell polaritybased origin for the variability of appendage number in S. pattersoni. Our results suggest that species deploy different combinations of apically and basally driven mechanisms to convert a two-dimensional primordium into a three-dimensional structure, and provide new directions for exploring the molecular origins of interspecies morphological variation.

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Section: Introductionmentioning

confidence: 99%

Diversity of epithelial morphogenesis during eggshell formation in drosophilids

et al. 2015

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“…Previous studies have shown that regulation of Ttk69, a zinc-finger protein, plays an important role during late oogenesis (French et al 2003). At stage 10B, Ttk69 functions to promote dorsal appendage tube elongation and chorion gene amplification (Sun et al 2008;Boyle and Berg 2009;Peters et al 2013).…”

Section: Mir-318 Interacts With Ttk69mentioning

confidence: 99%

Regulation of Pattern Formation and Gene Amplification During Drosophila Oogenesis by the miR-318 microRNA

Deng

Guo

et al. 2015

Genetics

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Pattern formation during epithelial development requires the coordination of multiple signaling pathways. Here, we investigate the functions of an ovary-enriched miRNA, miR-318, in epithelial development during Drosophila oogenesis. mir-318 maternal loss-of-function mutants were female-sterile and laid eggs with abnormal morphology. Removal of mir-318 disrupted the dorsal-anterior follicle cell patterning, resulting in abnormal dorsal appendages. mir-318 mutant females also produced thin and fragile eggshells due to impaired chorion gene amplification. We provide evidence that the ecdysone signaling pathway activates expression of miR-318 and that miR-318 cooperates with Tramtrack69 to control the switch from endocycling to chorion gene amplification during differentiation of the follicular epithelium. The multiple functions of miR-318 in oogenesis illustrate the importance of miRNAs in maintaining cell fate and in promoting the developmental transition in the female follicular epithelium.

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“…The following alleles were used in this study: FRT42D miR-7 Δ1 (a gift from R. W. Carthew, Northwestern University, Evanston, IL, USA), a null allele generated by excision of the miR-7 sequence, last two exons of bl and two exons of hillarin (Li and Carthew 2005), UAS-miR-7.140 (a gift from S. M. Cohen, Institute of Molecular and Cellular Biology, Singapore) (Stark et al, 2003), ttk69-RNAi (Vienna Drosophila RNAi Center), UAS-Ttk69 (Bloomington Stock Center BL7361), FRT82B ttk 1e11 (French et al, 2003) and -253/-39 lacZ (VM32E-lacZ) (Cavaliere et al, 2008). Notch reporters were E(spl)mβ-CD2 (de Celis et al, 1998), m7-lacZ (Assa-Kunik et al, 2007 and GbeL-lacZ (Furriols and Bray, 2001 Flies were maintained and raised at 25°C.…”

Section: Fly Stocks and Genetic Clonesmentioning

confidence: 99%

The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells

et al. 2013

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SUMMARYDevelopment in multicellular organisms includes both small incremental changes and major switches of cell differentiation and proliferation status. During Drosophila oogenesis, the follicular epithelial cells undergo two major developmental switches that cause global changes in the cell-cycle program. One, the switch from the endoreplication cycle to a gene-amplification phase, during which special genomic regions undergo repeated site-specific replication, is attributed to Notch downregulation, ecdysone signaling activation and upregulation of the zinc-finger protein Tramtrack69 (Ttk69). Here, we report that the microRNA miR-7 exerts an additional layer of regulation in this developmental switch by regulating Ttk69 transcripts. miR-7 recognizes the 3′ UTR of ttk69 transcripts and regulates Ttk69 expression in a dose-dependent manner. Overexpression of miR-7 effectively blocks the switch from the endocycle to gene amplification through its regulation of ttk69. miR-7 and Ttk69 also coordinate other cell differentiation events, such as vitelline membrane protein expression, that lead to the formation of the mature egg. Our studies reveal the important role miR-7 plays in developmental decision-making in association with signal-transduction pathways.

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The Drosophila Female Sterile Mutation twin peaks Is a Novel Allele of tramtrack and Reveals a Requirement for Ttk69 in Epithelial Morphogenesis

Cited by 41 publications

References 62 publications

Diversity of epithelial morphogenesis during eggshell formation in drosophilids

Diversity of epithelial morphogenesis during eggshell formation in drosophilids

Regulation of Pattern Formation and Gene Amplification During Drosophila Oogenesis by the miR-318 microRNA

The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells

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