The Dreaming Brain/Mind: A Role in Understanding Complex Mental Disorders?

D’Agostino, Armando; Limosani, Ivan; Scarone, Silvio

doi:10.3389/fpsyt.2012.00003

Cited by 17 publications

(18 citation statements)

References 45 publications

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“…The prototype monoamine releaser amphetamine has been the most extensively studied monoamine releaser as a candidate medication to treat cocaine abuse. Amphetamine maintenance has demonstrated efficacy in most, but not all, double blind, placebo-controlled clinical trials [17–20]. Consistent with results from these clinical trials, preclinical choice studies in both nonhuman primates [21, 22] (Figure 1) and rats [23] and human laboratory choice studies [24, 25] have also reported that subchronic d -amphetamine treatment decreases cocaine choice.…”

Section: Evaluation Of Candidate Medications In Preclinical Drug Vs mentioning

confidence: 73%

“…Methylphenidate attenuated cocaine vs. money choice in a one human laboratory study [37], but it did not significantly alter cocaine use in clinical trials [38–41]. Modafanil decreased cocaine vs. money choice in one human laboratory study [42] and cocaine use in one clinical trial [43]; however, a more recent human laboratory study [44] and four other clinical trials [20, 38, 45, 46] reported no significant effect of modafanil on cocaine use. In contrast to this extensive literature on effects of monoamine transporter inhibitors in humans, to date, none of the compounds referenced above have been examined as treatments in preclinical cocaine vs. food choice procedures.…”

Section: Evaluation Of Candidate Medications In Preclinical Drug Vs mentioning

confidence: 99%

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Use of Preclinical Drug Vs. Food Choice Procedures to Evaluate Candidate Medications for Cocaine Addiction

Banks

Hutsell

Schwienteck

et al. 2015

Curr Treat Options Psych

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Opinion Statement Drug addiction is a disease that manifests as an inappropriate allocation of behavior towards the procurement and use of the abused substance and away from other behaviors that produce more adaptive reinforcers (e.g. exercise, work, family and social relationships). The goal of treating drug addiction is not only to decrease drug-maintained behaviors, but also to promote a reallocation of behavior towards alternative, nondrug reinforcers. Experimental procedures that offer concurrent access to both a drug reinforcer and an alternative, nondrug reinforcer provide a research tool for assessment of medication effects on drug choice and behavioral allocation. Choice procedures are currently the standard in human laboratory research on medications development. Preclinical choice procedures have been utilized in biomedical research since the early 1940’s, and during the last 10–15 years, their use for evaluation of medications to treat drug addiction has increased. We propose here that parallel use of choice procedures in preclinical and clinical studies will facilitate translational research on development of medications to treat cocaine addiction. In support of this proposition, a review of the literature suggests strong concordance between preclinical effectiveness of candidate medications to modify cocaine choice in nonhuman primates and rodents and clinical effectiveness of these medications to modify either cocaine choice in human laboratory studies or metrics of cocaine abuse in patients with cocaine use disorder. The strongest evidence for medication effectiveness in preclinical choice studies has been obtained with maintenance on the monoamine releaser d-amphetamine, a candidate agonist medication for cocaine use analogous to use of methadone to treat heroin abuse or nicotine formulations to treat tobacco dependence.

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Section: Evaluation Of Candidate Medications In Preclinical Drug Vs mentioning

confidence: 73%

Section: Evaluation Of Candidate Medications In Preclinical Drug Vs mentioning

confidence: 99%

Use of Preclinical Drug Vs. Food Choice Procedures to Evaluate Candidate Medications for Cocaine Addiction

Banks

Hutsell

Schwienteck

et al. 2015

Curr Treat Options Psych

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“…Next, incarceration was not a useful correlate of marijuana use trajectories, with the exception that the moderate decline group was more likely (at 12 months) to be incarcerated and the chronic group was less likely (at 24 months) to be incarcerated than the low group. Given data showing disproportionate rates of incarceration among African-American youth, with substance use being a salient risk factor for incarceration, early interventions are needed to reduce these health disparities (Mukku et al, 2012; Substance Abuse and Mental Health Service Administration, 2014a). …”

Section: 0 Discussionmentioning

confidence: 99%

Marijuana use trajectories among drug-using youth presenting to an urban emergency department: Violence and social influences

Walton

Epstein‐Ngo

Carter

et al. 2017

Drug and Alcohol Dependence

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Aims This paper examined longitudinal marijuana use trajectories among drug-using youth presenting to the ED to inform intervention development. Methods Given interest in substance use and violence, this study oversampled those presenting with assault injuries. Assault-injured youth (ages 14-24) endorsing past 6-month drug use (n=349), and a sex and age proportionally-sampled comparison group (n=250) endorsing drug use, completed a baseline assessment and follow-ups at 6, 12, 18, and 24 months. Latent class trajectory analyses examined days of marijuana use over 2 years. Multinomial regression analyses examined baseline, 12-month and 24-month factors associated with substance use trajectory groups. Results Trajectory analyses identified 5 groups: Low (Low; 28.2%; n=169); Intermittent (INT; 16.2%; n=97); Moderate Decline (MD; 12.0%; n=72); High decline (HD, 13.2%; n=79) and Chronic (C; 30.4%; n=182). At baseline, as compared to the Low group, the other trajectory groups were more likely to be male and have greater levels of physical aggression. At 12- and 24-months, negative and positive peer influences, incarceration and community violence were additional characteristics associated with the greater marijuana use trajectories (as compared to the Low group). Conclusions Interventions for drug-using youth presenting to the urban ED should address peer influences, physical aggression and community violence exposure, given the association between these characteristics and greater marijuana use trajectories.

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“…These areas include the anterior and posterior corpus callosum and tracts in the frontal and parietal regions of the brain. In addition, cocaine has been shown to alter the methylation of myelin genes in rodents (Nielsen et al, 2012b). However, the precise mechanisms that cause alterations in white matter remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Integrative Bayesian analysis of neuroimaging-genetic data with application to cocaine dependence

Azadeh

Hobbs

et al. 2016

NeuroImage

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Neuroimaging and genetic studies provide distinct and complementary information about the structural and biological aspects of a disease. Integrating the two sources of data facilitates the investigation of the links between genetic variability and brain mechanisms among different individuals for various medical disorders. This article presents a general statistical framework for integrative Bayesian analysis of neuroimaging-genetic (iBANG) data, which is motivated by a neuroimaging-genetic study in cocaine dependence. Statistical inference necessitated the integration of spatially dependent voxel-level measurements with various patient-level genetic and demographic characteristics under an appropriate probability model to account for the multiple inherent sources of variation. Our framework uses Bayesian model averaging to integrate genetic information into the analysis of voxel-wise neuroimaging data, accounting for spatial correlations in the voxels. Using multiplicity controls based on the false discovery rate, we delineate voxels associated with genetic and demographic features that may impact diffusion as measured by fractional anisotropy (FA) obtained from DTI images. We demonstrate the benefits of accounting for model uncertainties in both model fit and prediction. Our results suggest that cocaine consumption is associated with FA reduction in most white matter regions of interest in the brain. Additionally, gene polymorphisms associated with GABAergic, serotonergic and dopaminergic neurotransmitters and receptors were associated with FA.

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The Dreaming Brain/Mind: A Role in Understanding Complex Mental Disorders?

Cited by 17 publications

References 45 publications

Use of Preclinical Drug Vs. Food Choice Procedures to Evaluate Candidate Medications for Cocaine Addiction

Use of Preclinical Drug Vs. Food Choice Procedures to Evaluate Candidate Medications for Cocaine Addiction

Marijuana use trajectories among drug-using youth presenting to an urban emergency department: Violence and social influences

Integrative Bayesian analysis of neuroimaging-genetic data with application to cocaine dependence

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