The dramatic effect of small pH changes on the properties of chitosan hydrogels crosslinked with genipin

Delmar, Keren; Bianco‐Peled, Havazelet

doi:10.1016/j.carbpol.2015.03.039

Cited by 80 publications

(38 citation statements)

References 67 publications

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“…shown that the genipin-chitosan reaction is highly pH dependent leading to distinct 513 matrixes, differing in appearance, crosslinking density and mechanical properties 514 (Delmar and Bianco-Peled, 2015). Using the rubber elasticity theory, we 515 demonstrated that the mesh size of the network decreased from 41.9 nm to 32.2 nm 516 with an increase of the crosslinking pH from 4.0 to 5.5.…”

mentioning

confidence: 93%

Composite chitosan hydrogels for extended release of hydrophobic drugs

Delmar

Bianco‐Peled

2016

Carbohydrate Polymers

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confidence: 93%

Composite chitosan hydrogels for extended release of hydrophobic drugs

Delmar

Bianco‐Peled

2016

Carbohydrate Polymers

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“…According to the literature, altering the pH within the small range of 4.00–5.50 dramatically affects the reaction, leading to hydrogels differing both in appearance and in properties. This is because the degree of chitosan protonation depends on pH and the protonated chitosan reacts with genipin …”

Section: Resultsmentioning

confidence: 99%

“…In order to enhance the mechanical properties, crosslinkers such as glutaraldehyde, epichlorohydrin, carbodiimides, and triphosphate are used to chemically crosslink the polymer network. Genipin, a natural crosslinker, is a widely used crosslinking agent due to the low toxicity property compared to other crosslinkers . In addition, genipin crosslinked biomaterials have improved degradative behaviors compared to the glutaraldehyde crosslinked biomaterials.…”

Section: Introductionmentioning

confidence: 99%

“…Genipin, a natural crosslinker, is a widely used crosslinking agent due to the low toxicity property compared to other crosslinkers. [16][17][18][19] In addition, genipin crosslinked biomaterials have improved degradative behaviors compared to the glutaraldehyde crosslinked biomaterials. Besides these, genipin itself may also provide an additional therapeutic advantage by virtue of its anti-inflammatory behavior that has been proved by in vivo studies.…”

Section: Introductionmentioning

confidence: 99%

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Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Bal‐Öztürk

Karal-Yılmaz

Akgüner

et al. 2019

J of Applied Polymer Sci

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In this study, chitosan/alginic acid/zinc oxide (CHI/AA/ZnO) nanostructured hydrogel sponges were fabricated by incorporating ZnO nanoparticles (<100 nm) into polymer matrix to develop a new potential biomaterial for hemorrhage control. For this purpose, the crosslinked CHI/AA/ZnO nanostructured sponges were synthesized by freeze‐drying technique. Genipin was used as a crosslinker. The prepared chitosan‐based sponges were characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, and scanning electron microscopy—energy‐dispersive spectroscopy analysis. The effects of ZnO content on the physicochemical characteristics of sponge‐like nanostructured hydrogels were evaluated by swelling ratio in two different pH values. Physical immobilization of dexamethasone as a model drug in hydrogel matrix resulted sustained release of drug more than 3 days. Antibacterial activity of hydrogel sponges was assessed against Staphylococcus aureus. The cytotoxicity and hemostatic efficacy of crosslinked CHI/AA/ZnO sponge like‐nanostructured hydrogels was evaluated in vitro and in vivo, respectively. The results of this study demonstrated that the prepared CHI/AA/ZnO nanostructured sponge had the potential to be an antibacterial topical hemostat. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47522.

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“…To overcome this disadvantage, natural chemical crosslinking agent – genipine was applied. It was found from the literatures that the nature chemical crosslinking agent – genipin, had shown its ability to form stable crosslinked products 10 000 times less cytotoxic than glutaraldehyde (Arteche Pujana et al , , Delmar and Bianco‐Peled, , Sung et al , ).…”

Section: Introductionmentioning

confidence: 99%

Preparation of free‐standing chitosan membranes for Chlorella vulgaris harvest and examination on suppression of algae‐fouling properties

Wang

Liu

et al. 2018

Water & Environment J

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Free‐standing chitosan membranes were prepared using genipin as crosslinker, using several molecular weights of polyethylene glycol (PEG) as a void‐forming agent. The membrane surface formation and chitosan polymer chain crosslinking were confirmed through SEM and FTIR, respectively. The water flux was remarkably increased with increasing molecular weight of PEG employed in preparation of composite chitosan membrane (J∝[PEG(MW)]0.85), it appeared over 6000 Da of PEG. During Chlorella vulgaris harvest using chitosan membranes, focus was made on algae‐fouling caused by the deposition of cells and extracellular organic matter, and it was found that membranes employing lower molecular weight of PEG (under 10000 Da) had been maintaining the high flux recovery after alternating filtration cycles, in addition to PEG20000 containing membrane. The chitosan membrane prepared with lower molecular weight of PEG exhibited better suppression of algae‐fouling properties. The Chlorella vulgaris harvesting results indicated that cell rejection rate reached above 98%.

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The dramatic effect of small pH changes on the properties of chitosan hydrogels crosslinked with genipin

Cited by 80 publications

References 67 publications

Composite chitosan hydrogels for extended release of hydrophobic drugs

Composite chitosan hydrogels for extended release of hydrophobic drugs

Sponge‐like chitosan‐based nanostructured antibacterial material as a topical hemostat

Preparation of free‐standing chitosan membranes for Chlorella vulgaris harvest and examination on suppression of algae‐fouling properties

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