In this paper we assess the potential economic effects of climate change on Brazilian agriculture scenarios in different regions in a general equilibrium framework, using a detailed regional economic database for the year 2005. Two different climate change impact scenarios are simulated. This paper extends the Brazilian literature in three different ways: by considering detailed shocks by product and region; by highlighting the connections between the potential impacts of climate change on agriculture and the labor market, with an inter-regional focus; and by specifying the links between climate change forecasts for agriculture and household expenditures. Results show that climate change impacts on Brazilian agriculture would have a relatively small economic effect on the Brazilian economy in aggregate terms, but with severe consequences at the regional level, making a strong case for losses that would be concentrated in the poorest regions and for the poorest workers and households in those regions.